Rome2Rio

How to get fromLouisville to Illinoisby plane, bus (Greyhound, Flixbus), bus, train, car, or bus (Amtrak)

Find Transport to Illinois

See all options

There are 7 ways to get from Louisville to Illinois by plane, bus (Greyhound, Flixbus), bus, train, car, or bus (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Louisville International Airport to Chicago Midway International Airport

    best
    1. Fly from Louisville International Airport (SDF) to Chicago Midway International Airport (MDW)plane plane SDF - MDW
    3h 19m
    $59–398
  2. Bus

    cheapest
    1. Take the bus from Louisville Bus Station to Chicago Bus Stationbus bus Greyhound US0100
    6h
    $45–75
  3. Bus, train

    1. Take the bus from Louisville Bus Station to Indianapolis Union Stationbus bus Greyhound US0100 / ...
    2. Take the train from Indianapolis to Chicago Union Stationtrain train Cardinal
    7h 55m
    $73–164
  4. Drive  294.4 mi

    1. Drive from Louisville to Chicagocar car 294.4 mi
    5h 3m
    $54–78
  5. Fly Louisville International Airport to Chicago O'Hare International Airport

    1. Fly from Louisville International Airport (SDF) to Chicago O'Hare International Airport (ORD)plane plane SDF - ORD
    3h 46m
    $54–338
  6. Drive to Blue Grass Airport, fly to Chicago O'Hare International Airport

    1. Drive from Louisville to Lexington-Airport-LEXcar car
    2. Fly from Blue Grass Airport (LEX) to Chicago O'Hare International Airport (ORD)plane plane LEX - ORD
    3h 47m
    $55–284
  7. Bus via Lafayette (Amtrak)

    1. Take the bus from Louisville, KY to Lafayette Amtrak Stationbus bus Nashville
    2. Take the bus from Lafayette Amtrak Station to Chicago Union Stationbus bus Nashville
    7h
    $58–91

Louisville to Illinois by bus

Calendar40Weekly Buses
Duration6hAverage Duration
Ticket$45Cheapest Price
See schedules

Comparing Your Travel Options

What companies run services between Louisville, KY, USA and Illinois, USA?

Southwest Airlines flies from Louisville International Airport (SDF) to Chicago Midway International Airport (MDW) 4 times a day. Alternatively, Greyhound USA operates a bus from Louisville Bus Station to Chicago Bus Station 4 times a day. Tickets cost $45–75 and the journey takes 6h. Flixbus USA also services this route twice daily.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Booking & Getting There