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How to get fromLouisville to Illinoisby plane, bus (Greyhound, Flixbus), bus, train, car, or bus (Amtrak)

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There are 6 ways to get from Louisville to Illinois by plane, bus (Greyhound, Flixbus), bus, train, car, or bus (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Chicago Midway International Airport

    best
    1. Fly from Louisville International Airport (SDF) to Chicago Midway International Airport (MDW)plane plane SDF - MDW
    3h 19m
    $54–348

  2. Bus

    cheapest
    1. Take the bus from Louisville Bus Station to Chicago Bus Stationbus bus FlixBus 2512 / ...
    5h 40m
    $45–95

  3. Bus, train

    1. Take the bus from Louisville Bus Station to Indianapolis Union Stationbus bus Greyhound US0100 / ...
    2. Take the train from Indianapolis to Chicago Union Stationtrain train Cardinal
    7h 55m
    $83–180

  4. Drive 294.4 mi

    1. Drive from Louisville to Chicagocar car 294.4 mi
    5h 3m
    $54–78

  5. Fly to Chicago O'Hare International Airport

    1. Fly from Louisville International Airport (SDF) to Chicago O'Hare International Airport (ORD)plane plane SDF - ORD
    3h 51m
    $49–298

  6. Bus via Lafayette (Amtrak)

    1. Take the bus from Louisville, KY to Lafayette Amtrak Stationbus bus
    2. Take the bus from Lafayette Amtrak Station to Chicago Union Stationbus bus
    7h
    $58–91

Louisville to Illinois by bus

Calendar82Weekly Buses
Duration5h 40mAverage Duration
Ticket$45Cheapest Price
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Questions & Answers

Map of how to get from Louisville to Illinois.ExpandLaunch map view
  • Distance: 287.9 mi
  • Duration: 3h 19m

What companies run services between Louisville, KY, USA and Illinois, USA?

Southwest Airlines flies from Louisville International Airport (SDF) to Chicago Midway International Airport (MDW) 3 times a day. Alternatively, Jefferson Lines operates a bus from Louisville Bus Station to Chicago Bus Station every 4 hours. Tickets cost $75–110 and the journey takes 5h 40m. Two other operators also service this route.

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