There are 7 ways to get from Louisville to Independence by bus, train, car, plane, or bus (Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus, train
best- Take the bus from Louisville, KY to Evansville, INbus
- Take the bus from Evansville Bus Station to St Louis Bus Stationbus
- Take the train from St. Louis to Independence Stationtrain
12h 50m$208–399Drive 497.6 mi
cheapest- Drive from Louisville to Independencecar 497.6 mi
8h 19m$91–132Fly from Louisville International Airport
- Fly from Louisville International Airport (SDF) to Kansas City (MCI)plane SDF - MCI
8h 21m$132–753Bus
- Take the bus from Louisville, KY to Evansville, INbus
- Take the bus from Evansville Bus Station to St Louis Bus Stationbus
- Take the bus from St Louis Bus Station to Kansas City Bus Stationbus
13h 23m$108–239Drive to Covington, fly
- Drive from Louisville to Covington (CVG)car
- Fly from Covington (CVG) to Kansas City (MCI)plane CVG - MCI
8h 32m$187–1,025Bus to Nashville, fly
- Take the bus from Louisville, KY to Nashvillebus
- Fly from Nashville (BNA) to Kansas City (MCI)plane BNA - MCI
9h 33m$435–1,148Bus to Indianapolis, fly
- Take the bus from Louisville, KY to Indianapolis Union Stationbus
- Fly from Indianapolis (IND) to Kansas City (MCI)plane IND - MCI
9h 33m$683–1,158
Louisville to Independence by bus and train
Comparing Your Travel Options
The cheapest way to get from Louisville to Independence is to drive which costs $90 - $140 and takes 8h 19m.
The fastest way to get from Louisville to Independence is to drive which takes 8h 19m and costs $90 - $140.
No, there is no direct bus from Louisville to Independence. However, there are services departing from Louisville, KY and arriving at On White Oak At Osage Eb via Evansville Bus Station, St Louis Bus Station and East Village - Bay A. The journey, including transfers, takes approximately 13h 23m.
The distance between Louisville and Independence is 559 miles. The road distance is 500.5 miles.
The best way to get from Louisville to Independence without a car is to bus and train which takes 12h 50m and costs $200 - $400.
It takes approximately 12h 50m to get from Louisville to Independence, including transfers.
Louisville to Independence bus services, operated by Miller Transportation, depart from Louisville, KY station.
The best way to get from Louisville to Independence is to fly which takes 8h 21m and costs $130 - $800. Alternatively, you can bus, which costs $100 - $240 and takes 13h 23m.
Louisville to Independence bus services, operated by Miller Transportation, arrive at Evansville, IN station.
Independence is 1h behind Louisville. It is currently 8:35 AM in Louisville and 7:35 AM in Independence.
What companies run services between Louisville, KY, USA and Independence, MO, USA?
Southwest Airlines, United Airlines, and two other airlines fly from Louisville International Airport (SDF) to Kansas City (MCI) every 2 hours. Alternatively, you can take a bus from Louisville, KY to On White Oak At Osage Eb via Evansville Bus Station, St Louis Bus Station, Kansas City Bus Station, and East Village - Bay A in around 13h 23m.
- Website
- southwest.com
Flights from Louisville International Airport to Kansas City via Chicago Midway
- Ave. Duration
- 3h 50m
- When
- Monday to Wednesday
- Estimated price
- $130–750
Flights from Louisville International Airport to Kansas City via Nashville
- Ave. Duration
- 4h 1m
- When
- Saturday to Wednesday
- Estimated price
- $130–750
Flights from Louisville International Airport to Kansas City via Dallas
- Ave. Duration
- 5h 10m
- When
- Monday, Thursday, Friday, and Sunday
- Estimated price
- $190–950
Flights from Covington to Kansas City via Chicago Midway
- Ave. Duration
- 3h 47m
- When
- Saturday to Friday
- Estimated price
- $170–1,000
Flights from Covington to Kansas City via Nashville
- Ave. Duration
- 4h 21m
- When
- Saturday, Monday, Thursday, and Friday
- Estimated price
- $180–1,100
Flights from Nashville to Kansas City
- Ave. Duration
- 1h 46m
- When
- Every day
- Estimated price
- $110–650
Flights from Nashville to Kansas City via St. Louis
- Ave. Duration
- 3h 12m
- When
- Monday, Thursday, and Friday
- Estimated price
- $110–650
Flights from Nashville to Kansas City via Chicago Midway
- Ave. Duration
- 3h 50m
- When
- Monday, Thursday, and Friday
- Estimated price
- $140–750
Flights from Indianapolis to Kansas City
- Ave. Duration
- 1h 36m
- When
- Every day
- Estimated price
- $100–650
Flights from Indianapolis to Kansas City via Chicago Midway
- Ave. Duration
- 3h 38m
- When
- Saturday to Wednesday
- Estimated price
- $120–700
Flights from Indianapolis to Kansas City via Nashville
- Ave. Duration
- 3h 55m
- When
- Monday, Thursday, Friday, and Saturday
- Estimated price
- $140–800
- Website
- united.com
Flights from Louisville International Airport to Kansas City via Chicago O'Hare
- Ave. Duration
- 4h 43m
- When
- Every day
- Estimated price
- $130–750
Flights from Covington to Kansas City via Chicago O'Hare
- Ave. Duration
- 4h 32m
- When
- Every day
- Estimated price
- $180–1,000
- Website
- delta.com
Flights from Louisville International Airport to Kansas City via Atlanta
- Ave. Duration
- 4h 44m
- When
- Every day
- Estimated price
- $170–850
Flights from Louisville International Airport to Kansas City via Minneapolis
- Ave. Duration
- 4h 45m
- When
- Monday, Wednesday, Thursday, Friday, Sunday, and Tuesday
- Estimated price
- $170–850
Flights from Covington to Kansas City via Minneapolis
- Ave. Duration
- 4h 42m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $220–1,200
Flights from Covington to Kansas City via Detroit
- Ave. Duration
- 4h 43m
- When
- Every day
- Estimated price
- $200–1,100
Flights from Covington to Kansas City via Atlanta
- Ave. Duration
- 5h 8m
- When
- Every day
- Estimated price
- $240–1,200
- Website
- aa.com
Flights from Louisville International Airport to Kansas City via Chicago O'Hare
- Ave. Duration
- 5h 32m
- When
- Every day
- Estimated price
- $130–750
Flights from Covington to Kansas City via Chicago O'Hare
- Ave. Duration
- 4h 23m
- When
- Saturday, Monday, Tuesday, Thursday, and Friday
- Estimated price
- $180–1,000
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from St. Louis to Independence Station
- Ave. Duration
- 5h 10m
- Frequency
- Twice daily
- Estimated price
- $140–230
- Website
- Amtrak
- Phone
- +1 502-368-5644 x 135
- Website
- Miller Transportation
Bus from Louisville, KY to Evansville, IN
- Ave. Duration
- 2h 20m
- Frequency
- Once daily
- Estimated price
- $35–130
- Website
- Miller Transportation
Bus from Louisville, KY to Evansville, IN
- Ave. Duration
- 2h 20m
- Frequency
- Once daily
- Estimated price
- $35–130
- Website
- Miller Transportation
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Evansville Bus Station to St Louis Bus Station
- Ave. Duration
- 3h 20m
- Frequency
- Twice daily
- Estimated price
- $30–45
- Website
- Greyhound
Bus from Evansville Bus Station to St Louis Bus Station
- Ave. Duration
- 3h 20m
- Frequency
- Twice daily
- Estimated price
- $30–45
- Website
- Greyhound
Bus from St Louis Bus Station to Kansas City Bus Station
- Ave. Duration
- 4h
- Frequency
- 4 times a day
- Estimated price
- $40–70
- Website
- Greyhound
Rome2Rio's guide to Amtrak Thruway
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Bus from Louisville, KY to Nashville
- Ave. Duration
- 2h 55m
- Frequency
- Twice daily
- Estimated price
- $30–50
- Website
- Amtrak
- Adult
- $30–50
Bus from Louisville, KY to Indianapolis Union Station
- Ave. Duration
- 2h 20m
- Frequency
- Twice daily
- Estimated price
- $22–45
- Website
- Amtrak
- Adult
- $22–45
Want to know more about travelling around United States
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Booking & Getting There
Yes, the driving distance between Louisville to Independence is 501 miles. It takes approximately 8h 19m to drive from Louisville to Independence.
There are 377+ hotels available in Independence.










