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How to get fromLouisville to Iowaby plane, bus (Amtrak, Greyhound), bus, train, or car

Find Transport to Iowa

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There are 7 ways to get from Louisville to Iowa by plane, bus (Amtrak, Greyhound), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Des Moines

    best
    1. Fly from Louisville International Airport (SDF) to Des Moines (DSM)plane plane SDF - DSM
    5h 4m
    $100–486

  2. Fly to Quad City International Airport

    cheapest
    1. Fly from Louisville International Airport (SDF) to Quad City International Airport (MLI)plane plane SDF - MLI
    7h 13m
    $69–425

  3. Bus

    1. Take the bus from Louisville, KY to Indianapolis Union Stationbus bus Nashville
    2. Take the bus from Indianapolis Union Station to Des Moinesbus bus Greyhound US0157S
    13h 15m
    $111–184

  4. Bus, train

    1. Take the bus from Louisville, KY to Indianapolis Union Stationbus bus
    2. Take the train from Indianapolis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Galesburg Amtrak Stationtrain train
    4. Take the bus from Galesburg to Des Moinesbus bus
    17h 56m
    $251–419

  5. Drive  580.9 mi

    1. Drive from Louisville to Des Moinescar car 580.9 mi
    9h 46m
    $106–154

  6. Fly to Omaha

    1. Fly from Louisville International Airport (SDF) to Omaha (OMA)plane plane SDF - OMA
    5h 28m
    $147–733

  7. Fly to The Eastern Iowa Airport

    1. Fly from Louisville International Airport (SDF) to The Eastern Iowa Airport (CID)plane plane SDF - CID
    5h 44m
    $112–493

Louisville International Airport (SDF) to Des Moines (DSM) flights

Calendar112Weekly Planes
Duration5h 2mAverage Duration
Ticket$80Cheapest Price
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Comparing Your Travel Options

Map of how to get from Louisville to Iowa.ExpandLaunch map view
  • Distance: 491.6 mi
  • Duration: 5h 4m

What companies run services between Louisville, KY, USA and Iowa, USA?

Southwest Airlines, American Airlines, and two other airlines fly from Louisville International Airport (SDF) to Des Moines (DSM) hourly. Alternatively, you can take a bus from Louisville, KY to Des Moines via Indianapolis Union Station and Des Moines in around 13h 15m.

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Need to know: Greyhound

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