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How to get fromLouisville to Ithacaby plane, bus, train, car, bus (Amtrak, Flixbus), or bus (Amtrak, Greyhound, Flixbus)

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There are 11 ways to get from Louisville to Ithaca by plane, bus, train, car, bus (Amtrak, Flixbus), or bus (Amtrak, Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Ithaca Tompkins Regional Airport

    best
    1. Fly from Louisville International Airport (SDF) to Ithaca Tompkins Regional Airport (ITH)plane plane SDF - ITH
    6h 38m
    $72–403

  2. Bus, train via Toledo

    1. Take the bus from Louisville, KY to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis to Toledobus bus
    3. Take the train from Toledo to Rochestertrain train
    4. Take the bus from Rochester to Ithacabus bus 231
    17h 34m
    $254–464

  3. Bus, train

    1. Take the bus from Louisville, KY to Indianapolis Union Stationbus bus
    2. Take the train from Indianapolis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Syracuse Regional Transportation Centertrain train
    4. Take the bus from Syracuse Bus Station to Ithacabus bus
    24h 27m
    $493–829

  4. Drive  657.4 mi

    1. Drive from Louisville to Ithacacar car 657.4 mi
    11h 43m
    $109–157

  5. Fly to Rochester, bus

    1. Fly from Louisville International Airport (SDF) to Rochester (ROC)plane plane SDF - ROC
    2. Take the bus from Rochester to Ithacabus bus
    8h 18m
    $106–462

  6. Fly to Greater Binghamton Airport, bus

    1. Fly from Louisville International Airport (SDF) to Greater Binghamton Airport (BGM)plane plane SDF - BGM
    2. Take the bus from Binghamton to Ithacabus bus
    10h 1m
    $123–473

  7. Fly to Elmira/Corning Regional Airport, bus

    1. Fly from Louisville International Airport (SDF) to Elmira/Corning Regional Airport (ELM)plane plane SDF - ELM
    2. Take the bus from Transit Center - PO Side to Tompkins County Librarybus bus
    10h 7m
    $72–402

  8. Fly to Syracuse Hancock International Airport, bus

    1. Fly from Louisville International Airport (SDF) to Syracuse Hancock International Airport (SYR)plane plane SDF - SYR
    2. Take the bus from Syracuse Bus Station to Ithacabus bus
    9h 4m
    $85–435

  9. Bus via Cleveland

    1. Take the bus from Louisville, KY to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis to Toledobus bus
    3. Take the bus from Toledo to Clevelandbus bus
    4. Take the bus from Cleveland to Buffalobus bus
    5. Take the bus from Buffalo to Ithacabus bus
    18h 55m
    $100–254

  10. Bus

    1. Take the bus from Louisville, KY to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis Union Station to Columbusbus bus
    3. Take the bus from Columbus to Buffalobus bus
    4. Take the bus from Buffalo to Ithacabus bus
    20h 49m
    $137–222

  11. Bus, train #2

    1. Take the bus from Louisville, KY to Indianapolis Union Stationbus bus
    2. Take the train from Indianapolis to Newark Penn Stationtrain train
    3. Take the bus from Newark Penn Station to Ithacabus bus
    30h 28m
    $558–899

Louisville to Ithaca by bus and train

Calendar7Weekly Services
Duration17h 34mAverage Duration
Ticket$254Cheapest Price
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Comparing Your Travel Options

Map of how to get from Louisville to Ithaca.ExpandLaunch map view
  • Distance: 585.5 mi
  • Duration: 6h 38m

What companies run services between Louisville, KY, USA and Ithaca, NY, USA?

United Airlines and Air Canada fly from Louisville International Airport (SDF) to Ithaca Tompkins Regional Airport (ITH) 3 times a day. Alternatively, you can take a bus from Louisville, KY to Ithaca via Indianapolis, Toledo, Cleveland, and Buffalo in around 18h 55m.

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Want to know more about travelling around United States

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