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How to get fromLouisville to Jacksonvilleby plane, bus (Greyhound, Amtrak, Flixbus), car, bus, bus (Greyhound, Flixbus), or bus (Greyhound)

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There are 8 ways to get from Louisville to Jacksonville by plane, bus (Greyhound, Amtrak, Flixbus), car, bus, bus (Greyhound, Flixbus), or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Louisville International Airport to Jacksonville

    best
    1. Fly from Louisville International Airport (SDF) to Jacksonville (JAX)plane plane SDF - JAX
    6h 35m
    $98–606

  2. Bus via Nashville

    1. Take the bus from Louisville Bus Station to Nashville Bus Stationbus bus
    2. Take the bus from Nashville Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Jacksonvillebus bus
    16h
    $116–203

  3. Drive  682.9 mi

    1. Drive from Louisville to Jacksonvillecar car 682.9 mi
    13h 33m
    $125–180

  4. Bus to Covington, fly to Jacksonville

    1. Take the bus from Louisville to Cincinnatibus bus
    2. Fly from Covington (CVG) to Jacksonville (JAX)plane plane CVG - JAX
    7h 3m
    $123–698

  5. Bus to Nashville, fly to Jacksonville

    1. Take the bus from Louisville Bus Station to Nashville Bus Stationbus bus
    2. Fly from Nashville (BNA) to Jacksonville (JAX)plane plane BNA - JAX
    7h 42m
    $109–528

  6. Fly Louisville International Airport to Orlando Sanford, drive

    1. Fly from Louisville International Airport (SDF) to Orlando Sanford (SFB)plane plane SDF - SFB
    2. Drive from Orlando-Sanford-Airport-SFB to Jacksonvillecar car
    5h 43m
    $114–588

  7. Bus

    1. Take the bus from Louisville Bus Station to Atlanta Bus Stationbus bus Greyhound US0135 / ...
    2. Take the bus from Atlanta Bus Station to Jacksonvillebus bus FlixBus N2434 / ...
    16h 5m
    $117–198

  8. Bus via Tallahassee (Greyhound)

    1. Take the bus from Louisville Bus Station to Montgomery Intermodal Centerbus bus
    2. Take the bus from Montgomery Intermodal Center to Tallahasseebus bus
    3. Take the bus from Tallahassee to Jacksonvillebus bus
    20h
    $133–217

Louisville to Jacksonville by bus

Calendar34Weekly Buses
Duration16hAverage Duration
Ticket$116Cheapest Price
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Comparing Your Travel Options

Map of how to get from Louisville to Jacksonville.ExpandLaunch map view
  • Distance: 604 mi
  • Duration: 6h 35m

What companies run services between Louisville, KY, USA and Jacksonville, FL, USA?

Delta, Southwest Airlines, and American Airlines fly from Louisville International Airport (SDF) to Jacksonville (JAX) hourly. Alternatively, you can take a bus from Louisville Bus Station to Jacksonville via Nashville Bus Station and Atlanta Bus Station in around 16h.

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