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How to get fromLouisville to Jacksonvilleby plane, bus (Amtrak, Greyhound, Flixbus), bus, train, car, or bus (Greyhound, Amtrak)

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There are 9 ways to get from Louisville to Jacksonville by plane, bus (Amtrak, Greyhound, Flixbus), bus, train, car, or bus (Greyhound, Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Louisville International Airport to Albert J. Ellis Airport

    best
    1. Fly from Louisville International Airport (SDF) to Albert J. Ellis Airport (OAJ)plane plane SDF - OAJ
    5h 43m
    $107–483

  2. Fly Louisville International Airport to Greenville, bus

    cheapest
    1. Fly from Louisville International Airport (SDF) to Greenville (PGV)plane plane SDF - PGV
    2. Take the bus from Greenville GK Butterfield Trans Ctr to Jacksonville Bus Stopbus bus
    8h 38m
    $97–489

  3. Bus via Atlanta

    1. Take the bus from Louisville, KY to Nashvillebus bus
    2. Take the bus from Nashville Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Myrtle Beach Bus Stationbus bus
    4. Take the bus from Myrtle Beach Bus Station to Jacksonville Bus Stopbus bus
    22h 40m
    $136–266

  4. Bus, train

    1. Take the bus from Louisville, KY to Indianapolis Union Stationbus bus
    2. Take the train from Indianapolis to Alexandriatrain train
    3. Take the train from Alexandria to Wilsontrain train
    4. Take the bus from Wilson Bus Stop to Jacksonville Bus Stopbus bus
    31h 3m
    $322–704

  5. Drive 624.2 mi

    1. Drive from Louisville to Jacksonvillecar car 624.2 mi
    12h 8m
    $114–165

  6. Drive to Blue Grass Airport, fly to Albert J. Ellis Airport

    1. Drive from Louisville to Lexington-Airport-LEXcar car
    2. Fly from Blue Grass Airport (LEX) to Albert J. Ellis Airport (OAJ)plane plane LEX - OAJ
    5h 52m
    $133–609

  7. Fly Louisville International Airport to Wilmington International Airport, bus

    1. Fly from Louisville International Airport (SDF) to Wilmington International Airport (ILM)plane plane SDF - ILM
    2. Take the bus from Wilmington Amtrak Station to Jacksonville Amtrak Bus Stopbus bus
    7h 25m
    $112–514

  8. Fly Louisville International Airport to Coastal Carolina Regional Airport, bus

    1. Fly from Louisville International Airport (SDF) to Coastal Carolina Regional Airport (EWN)plane plane SDF - EWN
    2. Take the bus from New Bern to Jacksonville Bus Stopbus bus
    8h 31m
    $115–580

  9. Bus

    1. Take the bus from Louisville, KY Bus Station to Columbus - Downtown - Mound Stbus bus
    2. Take the bus from Columbus to Winston Salem(Trans Center)bus bus
    3. Take the bus from Winston Salem(Trans Center) to Wilson Bus Stopbus bus
    4. Take the bus from Wilson to Jacksonville Amtrak Bus Stopbus bus
    25h 5m
    $163–309

Louisville to Jacksonville by bus

Calendar7Weekly Buses
Duration22h 40mAverage Duration
Ticket$136Cheapest Price
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Questions & Answers

Map of how to get from Louisville to Jacksonville.ExpandLaunch map view
  • Distance: 528 mi
  • Duration: 5h 43m

What companies run services between Louisville, KY, USA and Jacksonville, NC, USA?

Delta and American Airlines fly from Louisville International Airport (SDF) to Albert J. Ellis Airport (OAJ) every 4 hours. Alternatively, you can take a bus from Louisville, KY to Jacksonville Bus Stop via Nashville Bus Station, Atlanta Bus Station, and Myrtle Beach Bus Station in around 22h 40m.

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Train operators
Bus operators

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