Rome2Rio

How to get fromLouisville to Key Westby plane, bus (Amtrak, Greyhound, Flixbus), car, bus, or shuttle

Find Transport to Key West

See all options

There are 7 ways to get from Louisville to Key West by plane, bus (Amtrak, Greyhound, Flixbus), car, bus, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Louisville International Airport

    best
    1. Fly from Louisville International Airport (SDF) to Key West International Airport (EYW)plane plane SDF - EYW
    5h 42m
    $98–446

  2. Drive to Blue Grass Airport, fly

    cheapest
    1. Drive from Louisville to Lexington-Airport-LEXcar car
    2. Fly from Blue Grass Airport (LEX) to Key West International Airport (EYW)plane plane LEX - EYW
    5h 41m
    $94–382

  3. Bus

    1. Take the bus from Louisville, KY to Nashvillebus bus
    2. Take the bus from Nashville Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Miami Airport Stationbus bus
    4. Take the bus from Miami Airport Station to Big Pine Keybus bus
    5. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    29h 56m
    $178–345

  4. Drive  1,173.5 mi

    1. Drive from Louisville to Key Westcar car 1,173.5 mi
    22h 6m
    $215–310

  5. Bus to Covington, fly

    1. Take the bus from Louisville, KY Bus Station to Cincinnati - Downtownbus bus
    2. Fly from Covington (CVG) to Key West International Airport (EYW)plane plane CVG - EYW
    6h 22m
    $123–538

  6. Bus to Evansville, fly

    1. Take the bus from Louisville, KY to Evansville, INbus bus
    2. Fly from Evansville (EVV) to Key West International Airport (EYW)plane plane EVV - EYW
    8h 44m
    $140–512

  7. Bus, shuttle

    1. Take the bus from Louisville, KY to Nashvillebus bus
    2. Take the bus from Nashville Bus Station to Tallahasseebus bus
    3. Take the bus from Tallahassee - FSU - Old St Augustine at Intramural Field to Miami Airportbus bus
    4. Take a shuttle bus from Miami, FL - International Airport to Key West, FLshuttle bus
    30h 19m
    $382–612

Louisville to Key West by bus and foot

Calendar14Weekly Services
Duration29h 56mAverage Duration
Ticket$178Cheapest Price
See schedules

Questions & Answers

Map of how to get from Louisville to Key West.ExpandLaunch map view
  • Distance: 979 mi
  • Duration: 5h 42m

What companies run services between Louisville, KY, USA and Key West, FL, USA?

Delta and American Airlines fly from Louisville International Airport (SDF) to Key West International Airport (EYW) every 4 hours. Alternatively, you can take a bus from Louisville, KY to N Roosevelt & 3rd Street via Nashville Bus Station, Atlanta Bus Station, Miami Airport Station, Big Pine Key, and Big Pine Key - CVS / MM30 in around 29h 56m.

Airlines
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers