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How to get fromLouisville to Key Westby plane, bus, ferry, car, or bus (Amtrak, Greyhound, Flixbus)

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There are 7 ways to get from Louisville to Key West by plane, bus, ferry, car, or bus (Amtrak, Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Louisville International Airport

    best
    1. Fly from Louisville International Airport (SDF) to Key West International Airport (EYW)plane plane SDF - EYW
    5h 54m
    $103–466

  2. Bus, ferry

    1. Take the bus from Louisville, KY to Nashvillebus bus
    2. Take the bus from Nashville Bus Station to Tallahasseebus bus
    3. Take the bus from Tallahassee to Fort Myersbus bus
    4. Take the ferry from Fort Myers Beach, FL to Key West, FLferry ferry
    28h 26m
    $370–488

  3. Drive 1,175 mi

    1. Drive from Louisville to Key Westcar car 1,175 mi
    22h 6m
    $215–310

  4. Drive to Blue Grass Airport, fly

    1. Drive from Louisville to Lexington-Airport-LEXcar car
    2. Fly from Blue Grass Airport (LEX) to Key West International Airport (EYW)plane plane LEX - EYW
    5h 47m
    $124–582

  5. Bus to Covington, fly

    1. Take the bus from Louisville, KY Bus Station to Cincinnati - Downtownbus bus
    2. Fly from Covington (CVG) to Key West International Airport (EYW)plane plane CVG - EYW
    6h 23m
    $123–538

  6. Bus to Evansville, fly

    1. Take the bus from Louisville, KY to Evansville, INbus bus
    2. Fly from Evansville (EVV) to Key West International Airport (EYW)plane plane EVV - EYW
    8h 40m
    $145–459

  7. Bus

    1. Take the bus from Louisville, KY to Nashvillebus bus
    2. Take the bus from Nashville Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Miami Airport Stationbus bus
    4. Take the bus from Miami Airport Station to Big Pine Keybus bus
    5. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    29h 56m
    $189–365

Louisville to Key West by bus and foot

Calendar14Weekly Services
Duration29h 56mAverage Duration
Ticket$189Cheapest Price
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Questions & Answers

Map of how to get from Louisville to Key West.ExpandLaunch map view
  • Distance: 979 mi
  • Duration: 5h 54m

What companies run services between Louisville, KY, USA and Key West, FL, USA?

Delta, American Airlines, and Breeze Airways fly from Louisville International Airport (SDF) to Key West International Airport (EYW) 5 times a day. Alternatively, you can take a bus from Louisville, KY to N Roosevelt & 3rd Street via Nashville Bus Station, Atlanta Bus Station, Miami Airport Station, Big Pine Key, and Big Pine Key - CVS / MM30 in around 29h 56m.

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