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How to get fromLouisville to Key Westby plane, bus (Greyhound, Amtrak, Flixbus), car, bus, bus (Greyhound, Flixbus), or bus (Greyhound)

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There are 8 ways to get from Louisville to Key West by plane, bus (Greyhound, Amtrak, Flixbus), car, bus, bus (Greyhound, Flixbus), or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Louisville International Airport

    best
    1. Fly from Louisville International Airport (SDF) to Key West International Airport (EYW)plane plane SDF - EYW
    5h 51m
    $108–506

  2. Drive to Blue Grass Airport, fly

    cheapest
    1. Drive from Louisville to Lexington-Airport-LEXcar car
    2. Fly from Blue Grass Airport (LEX) to Key West International Airport (EYW)plane plane LEX - EYW
    5h 18m
    $94–402

  3. Bus via Nashville

    1. Take the bus from Louisville Bus Station to Nashville Bus Stationbus bus
    2. Take the bus from Nashville Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Miami Airport Stationbus bus
    4. Take the bus from Miami Airport Station to Big Pine Keybus bus
    5. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    29h 51m
    $183–317

  4. Drive  1,173.5 mi

    1. Drive from Louisville to Key Westcar car 1,173.5 mi
    22h 6m
    $215–310

  5. Bus to Covington, fly

    1. Take the bus from Louisville to Cincinnatibus bus
    2. Fly from Covington (CVG) to Key West International Airport (EYW)plane plane CVG - EYW
    6h 13m
    $123–608

  6. Bus to Evansville, fly

    1. Take the bus from Louisville, KY to Evansville, INbus bus
    2. Fly from Evansville (EVV) to Key West International Airport (EYW)plane plane EVV - EYW
    8h 52m
    $145–542

  7. Bus

    1. Take the bus from Louisville Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Miami Airport Stationbus bus
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    4. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    29h 56m
    $184–312

  8. Bus via Tallahassee

    1. Take the bus from Louisville Bus Station to Montgomery Intermodal Centerbus bus
    2. Take the bus from Montgomery Intermodal Center to Tallahasseebus bus
    3. Take the bus from Tallahassee to Miami Airport Stationbus bus
    4. Take the bus from Miami Airport Station to Big Pine Keybus bus
    5. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    36h 31m
    $215–351

Louisville to Key West by bus and foot

Calendar14Weekly Services
Duration29h 51mAverage Duration
Ticket$183Cheapest Price
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Comparing Your Travel Options

Map of how to get from Louisville to Key West.ExpandLaunch map view
  • Distance: 979 mi
  • Duration: 5h 51m

What companies run services between Louisville, KY, USA and Key West, FL, USA?

Delta, Allegiant Air, and American Airlines fly from Louisville International Airport (SDF) to Key West International Airport (EYW) every 4 hours. Alternatively, you can take a bus from Louisville Bus Station to N Roosevelt & 3rd Street via Nashville Bus Station, Atlanta Bus Station, Miami Airport Station, Big Pine Key, and Big Pine Key - CVS / MM30 in around 29h 51m.

Airlines
Bus operators

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