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How to get fromLouisville to Kirksvilleby plane, bus, train, or car

Find Transport to Kirksville

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There are 8 ways to get from Louisville to Kirksville by plane, bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Louisville International Airport to Kirksville Regional Airport

    best
    1. Fly from Louisville International Airport (SDF) to Kirksville Regional Airport (IRK)plane plane SDF - IRK
    7h 2m
    $117–478

  2. Fly Louisville International Airport to Burlington Municipal Airport, drive

    cheapest
    1. Fly from Louisville International Airport (SDF) to Burlington Municipal Airport (BRL)plane plane SDF - BRL
    2. Drive from Burlington Municipal Airport (BRL) to Kirksvillecar car
    8h 29m
    $63–288

  3. Bus, train

    1. Take the bus from Louisville, KY to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis Union Station to Galesburgbus bus
    3. Take the train from Galesburg Amtrak Station to La Plata Stationtrain train
    11h 45m
    $143–264

  4. Bus, train via Chicago (Amtrak)

    1. Take the bus from Louisville, KY to Indianapolis Union Stationbus bus
    2. Take the train from Indianapolis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to La Plata Stationtrain train
    14h 29m
    $223–429

  5. Drive 463.7 mi

    1. Drive from Louisville to Kirksvillecar car 463.7 mi
    7h 59m
    $85–123

  6. Drive to Blue Grass Airport, fly to Kirksville Regional Airport

    1. Drive from Louisville to Lexington-Airport-LEXcar car
    2. Fly from Blue Grass Airport (LEX) to Kirksville Regional Airport (IRK)plane plane LEX - IRK
    6h 56m
    $148–614

  7. Fly Louisville International Airport to Chicago Midway International Airport, train

    1. Fly from Louisville International Airport (SDF) to Chicago Midway International Airport (MDW)plane plane SDF - MDW
    2. Take the train from Chicago Union Station to La Plata Stationtrain train
    9h 44m
    $197–616

  8. Bus to Covington, fly to Kirksville Regional Airport

    1. Take the bus from Louisville, KY Bus Station to Cincinnati - Downtownbus bus
    2. Fly from Covington (CVG) to Kirksville Regional Airport (IRK)plane plane CVG - IRK
    8h 35m
    $187–740

Louisville International Airport (SDF) to Kirksville Regional Airport (IRK) flights

Calendar25Weekly Planes
Duration7h 48mAverage Duration
Ticket$79Cheapest Price
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Questions & Answers

Map of how to get from Louisville to Kirksville.ExpandLaunch map view
  • Distance: 401.8 mi
  • Duration: 7h 2m

What companies run services between Louisville, KY, USA and Kirksville, MO, USA?

American Airlines, Corporate Flight Management Inc, and two other airlines fly from Louisville International Airport (SDF) to Kirksville Regional Airport (IRK) 4 times a day.

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