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How to get fromLouisville to Knoxvilleby plane, bus (Greyhound, Amtrak), or car

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There are 4 ways to get from Louisville to Knoxville by plane, bus (Greyhound, Amtrak), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Mcghee Tyson Airport

    best
    1. Fly from Louisville International Airport (SDF) to Mcghee Tyson Airport (TYS)plane plane SDF - TYS
    5h 12m
    $157–773

  2. Drive 234.4 mi

    cheapest
    1. Drive from Louisville to Knoxvillecar car 234.4 mi
    4h 30m
    $43–62

  3. Bus

    1. Take the bus from Louisville Bus Station to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis to New York Midtownbus bus
    3. Take the bus from New York to Knoxvillebus bus Nyc
    32h 55m

  4. Fly to Nashville, drive

    1. Fly from Louisville International Airport (SDF) to Nashville (BNA)plane plane SDF - BNA
    2. Drive from Nashville-Airport-BNA to Knoxvillecar car
    5h 17m
    $82–413

Louisville International Airport (SDF) to Mcghee Tyson Airport (TYS) flights

Calendar108Weekly Planes
Duration4h 35mAverage Duration
Ticket$107Cheapest Price
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Questions & Answers

Map of how to get from Louisville to Knoxville.ExpandLaunch map view
  • Distance: 210 mi
  • Duration: 5h 12m

What companies run services between Louisville, KY, USA and Knoxville, TN, USA?

Delta, American Airlines, and three other airlines fly from Louisville International Airport (SDF) to Mcghee Tyson Airport (TYS) hourly. Alternatively, you can take a bus from Louisville Bus Station to Knoxville via Indianapolis, Illinois St (Greyhound Bus Station), Indianapolis, New York Midtown, 23 St, East Broadway, New York, and Knoxville in around 32h 55m.

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