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How to get fromLouisville to La Crosseby plane, bus, train, car, bus (Amtrak), or bus (Amtrak, Greyhound, Flixbus)

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There are 8 ways to get from Louisville to La Crosse by plane, bus, train, car, bus (Amtrak), or bus (Amtrak, Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Louisville International Airport

    best
    1. Fly from Louisville International Airport (SDF) to La Crosse (LSE)plane plane SDF - LSE
    6h 25m
    $96–446

  2. Bus, train (Amtrak)

    1. Take the bus from Louisville, KY to Chicago Union Stationbus bus
    2. Take the train from Chicago Union Station to La Crosse Amtrak Stationtrain train Empire Builder / ...
    11h 59m
    $140–247

  3. Bus, train via Indianapolis (Amtrak)

    1. Take the bus from Louisville, KY to Indianapolis Union Stationbus bus
    2. Take the train from Indianapolis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to La Crosse Amtrak Stationtrain train
    14h 19m
    $173–364

  4. Drive 575.8 mi

    1. Drive from Louisville to La Crossecar car 575.8 mi
    9h 43m
    $106–152

  5. Drive to Blue Grass Airport, fly

    1. Drive from Louisville to Lexington-Airport-LEXcar car
    2. Fly from Blue Grass Airport (LEX) to La Crosse (LSE)plane plane LEX - LSE
    7h
    $127–592

  6. Bus to Covington, fly

    1. Take the bus from Louisville, KY Bus Station to Cincinnati - Downtownbus bus
    2. Fly from Covington (CVG) to La Crosse (LSE)plane plane CVG - LSE
    7h 51m
    $111–538

  7. Bus

    1. Take the bus from Louisville, KY to Chicago Union Stationbus bus
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to La Crossebus bus
    13h 58m
    $110–167

  8. Bus via Indianapolis

    1. Take the bus from Louisville, KY to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis Union Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Wisconsin Dellsbus bus
    4. Take the bus from Wisconsin Dells to La Crossebus bus
    14h 50m
    $111–204

Louisville to La Crosse by bus and train (Amtrak)

Calendar14Weekly Services
Duration11h 59mAverage Duration
Ticket$140Cheapest Price
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Questions & Answers

Map of how to get from Louisville to La Crosse.ExpandLaunch map view
  • Distance: 500.9 mi
  • Duration: 6h 25m

What companies run services between Louisville, KY, USA and La Crosse, WI, USA?

United Airlines and American Airlines fly from Louisville International Airport (SDF) to La Crosse (LSE) 5 times a day. Alternatively, you can take a bus from Louisville, KY to La Crosse via Chicago Union Station, W Jackson Blvd, after S Clinton St, and Madison in around 13h 58m.

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