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How to get fromLouisville to Lewistonby plane, bus, bus (Flixbus, Greyhound), train, car, or bus (Amtrak, Greyhound)

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There are 10 ways to get from Louisville to Lewiston by plane, bus, bus (Flixbus, Greyhound), train, car, or bus (Amtrak, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Louisville International Airport to Portland, bus

    best
    1. Fly from Louisville International Airport (SDF) to Portland (PWM)plane plane SDF - PWM
    2. Take the bus from City of Portland to Lewiston Bus Stopbus bus
    8h 19m
    $129–617

  2. Fly Louisville International Airport to Boston Logan Airport, bus

    cheapest
    1. Fly from Louisville International Airport (SDF) to Boston Logan Airport (BOS)plane plane SDF - BOS
    2. Take the bus from Logan International Airport to Portland, MEbus bus
    3. Take the bus from City of Portland to Lewiston Bus Stopbus bus
    9h 3m
    $126–527

  3. Bus via Columbus

    1. Take the bus from Louisville, KY Bus Station to Columbus - Downtown - Mound Stbus bus
    2. Take the bus from Columbus, OH to New York, NYbus bus
    3. Take the bus from NYC Downtown to Bostonbus bus
    4. Take the bus from Boston to Lewiston Bus Stopbus bus
    25h 24m
    $182–274

  4. Bus, train via Cleveland

    1. Take the bus from Louisville, KY Bus Station to Cleveland Ohio Greyhound Stationbus bus
    2. Take the train from Cleveland Amtrak to Bostontrain train
    3. Take the bus from Boston to Lewiston Bus Stopbus bus
    27h 35m
    $269–578

  5. Drive 1,066.1 mi

    1. Drive from Louisville to Lewistoncar car 1,066.1 mi
    19h 5m
    $195–281

  6. Bus to Covington, fly to Portland, bus

    1. Take the bus from Louisville, KY Bus Station to Cincinnati - Downtownbus bus
    2. Fly from Covington (CVG) to Portland (PWM)plane plane CVG - PWM
    3. Take the bus from City of Portland to Lewiston Bus Stopbus bus
    8h 48m
    $159–1,459

  7. Bus to Nashville, fly to Portland, bus

    1. Take the bus from Louisville, KY to Nashvillebus bus
    2. Fly from Nashville (BNA) to Portland (PWM)plane plane BNA - PWM
    3. Take the bus from City of Portland to Lewiston Bus Stopbus bus
    9h 55m
    $162–662

  8. Bus

    1. Take the bus from Louisville, KY to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis Union Station to Port Authority Bus Terminalbus bus
    3. Take the bus from Port Authority Bus Terminal to Bostonbus bus
    4. Take the bus from Boston to Lewiston Bus Stopbus bus
    33h 7m
    $194–384

  9. Bus, train

    1. Take the bus from Louisville, KY to Indianapolis Union Stationbus bus
    2. Take the train from Indianapolis to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the train from Ny Moynihan Train Hall At Penn Station to Bostontrain train
    4. Take the bus from Boston to Lewiston Bus Stopbus bus
    34h 21m
    $414–899

  10. Bus, train via Chicago

    1. Take the bus from Louisville, KY to Indianapolis Union Stationbus bus
    2. Take the train from Indianapolis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Springfieldtrain train
    4. Take the bus from Springfield Union Station to City of Portlandbus bus
    5. Take the bus from City of Portland to Lewiston Bus Stopbus bus
    35h 44m
    $408–889

Louisville to Lewiston by bus and foot

Calendar7Weekly Services
Duration25h 24mAverage Duration
Ticket$182Cheapest Price
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Questions & Answers

Map of how to get from Louisville to Lewiston.ExpandLaunch map view
  • Distance: 935.1 mi
  • Duration: 8h 19m

What companies run services between Louisville, KY, USA and Lewiston, ME, USA?

You can take a bus from Louisville, KY Bus Station to Lewiston Bus Stop via Columbus - Downtown - Mound St, Columbus, OH, New York, NY, NYC Downtown, and Boston in around 25h 24m.

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