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How to get fromLouisville to Lexingtonby plane, bus (Greyhound), car, or train

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There are 6 ways to get from Louisville to Lexington by plane, bus (Greyhound), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Louisville International Airport to Piedmont Triad International Airport

    best
    1. Fly from Louisville International Airport (SDF) to Piedmont Triad International Airport (GSO)plane plane SDF - GSO
    7h 47m
    $133–680

  2. Drive 440.7 mi

    cheapest
    1. Drive from Louisville to Lexingtoncar car 440.7 mi
    8h 30m
    $81–117

  3. Bus

    1. Take the bus from Louisville, KY Bus Station to N Wilson Rd & Ferrell Pl - Columbusbus bus
    2. Take the bus from Wilson & Ferrell Shell Station - Columbus to Winston Salem(Trans Center)bus bus
    3. Take the bus from Winston Salem(Trans Center) to Lexington Davidson Co Trans Termbus bus
    16h 50m
    $85–186

  4. Fly Louisville International Airport to Charlotte Douglas International Airport, train

    1. Fly from Louisville International Airport (SDF) to Charlotte Douglas International Airport (CLT)plane plane SDF - CLT
    2. Take the train from Charlotte Amtrak Station to High Pointtrain train
    7h 52m
    $122–668

  5. Drive to Blue Grass Airport, fly to Charlotte Douglas International Airport, train

    1. Drive from Louisville to Lexington-Airport-LEXcar car
    2. Fly from Blue Grass Airport (LEX) to Charlotte Douglas International Airport (CLT)plane plane LEX - CLT
    3. Take the train from Charlotte Amtrak Station to High Pointtrain train
    7h 44m
    $143–784

  6. Fly Louisville International Airport to Raleigh-Durham International Airport, train

    1. Fly from Louisville International Airport (SDF) to Raleigh-Durham International Airport (RDU)plane plane SDF - RDU
    2. Take the train from Durham Amtrak Station to High Pointtrain train
    8h 11m
    $111–543

Louisville to Lexington by bus

Calendar14Weekly Buses
Duration16h 50mAverage Duration
Ticket$85Cheapest Price
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Questions & Answers

Map of how to get from Louisville to Lexington.ExpandLaunch map view
  • Distance: 390.9 mi
  • Duration: 7h 47m

What companies run services between Louisville, KY, USA and Lexington, NC, USA?

Delta, American Airlines, and United Airlines fly from Louisville International Airport (SDF) to Piedmont Triad International Airport (GSO) hourly. Alternatively, you can take a bus from Louisville, KY Bus Station to Lexington Davidson Co Trans Term via Wilson & Ferrell Shell Station - Columbus and Winston Salem(Trans Center) in around 16h 50m.

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