There are 5 ways to get from Louisville to Lexington by plane, bus (Amtrak, Greyhound, Flixbus), car, or bus (Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from Louisville International Airport
best- Fly from Louisville International Airport (SDF) to Columbia (CAE)plane SDF - CAE
4h 59m$200–1,138Drive 467.5 mi
cheapest- Drive from Louisville to Lexingtoncar 467.5 mi
9h 30m$86–124Bus
- Take the bus from Louisville, KY to Nashvillebus
- Take the bus from Nashville Bus Station to Atlanta Bus Stationbus
- Take the bus from Atlanta Bus Station to Camdenbus
- Take the bus from Camden to Columbia, SCbus Nyc
16h 25m$161–276Drive to Blue Grass Airport, fly
- Drive from Louisville to Lexington-Airport-LEXcar
- Fly from Blue Grass Airport (LEX) to Columbia (CAE)plane LEX - CAE
4h 51m$241–1,354Bus via Hurricane
- Take the bus from Louisville, KY Bus Station to Columbus - Downtown - Mound Stbus
- Take the bus from Columbus - Mound St to Hurricanebus
- Take the bus from Hurricane to Charlotte Bus Stationbus
- Take the bus from Charlotte Bus Station to Camdenbus
- Take the bus from Camden to Columbia, SCbus Nyc
20h 40m$133–292
Louisville International Airport (SDF) to Columbia (CAE) flights
Questions & Answers
The cheapest way to get from Louisville to Lexington is to drive which costs $85 - $130 and takes 9h 30m.
The fastest way to get from Louisville to Lexington is to drive and fly which takes 4h 51m and costs $240 - $1,400.
No, there is no direct bus from Louisville to Lexington. However, there are services departing from Louisville, KY and arriving at Columbia, SC via Nashville Bus Station, Atlanta Bus Station and Camden. The journey, including transfers, takes approximately 16h 25m.
The distance between Louisville and Lexington is 407 miles. The road distance is 470.3 miles.
The best way to get from Louisville to Lexington without a car is to bus which takes 16h 25m and costs $160 - $280.
It takes approximately 4h 59m to get from Louisville to Lexington, including transfers.
Louisville to Lexington bus services, operated by Amtrak Thruway, depart from Louisville, KY station.
The best way to get from Louisville to Lexington is to fly which takes 4h 59m and costs $200 - $1,200. Alternatively, you can bus, which costs $160 - $280 and takes 16h 25m.
Louisville to Lexington bus services, operated by Amtrak Thruway, arrive at Nashville station.
Yes, the driving distance between Louisville to Lexington is 470 miles. It takes approximately 9h 30m to drive from Louisville to Lexington.
What companies run services between Louisville, KY, USA and Lexington, SC, USA?
Delta, American Airlines, and United Airlines fly from Louisville International Airport (SDF) to Columbia (CAE) hourly. Alternatively, you can take a bus from Louisville, KY to Lexington via Nashville Bus Station, Atlanta Bus Station, Camden, and Columbia, SC in around 16h 25m.
- Website
- aa.com
Flights from Louisville International Airport to Columbia via Charlotte
- Ave. Duration
- 4h 5m
- When
- Every day
- Estimated price
- $170–1,100
Flights from Louisville International Airport to Columbia via Reagan Washington
- Ave. Duration
- 6h 11m
- When
- Every day
- Estimated price
- $270–1,300
Flights from Louisville International Airport to Columbia via Philadelphia
- Ave. Duration
- 5h 7m
- When
- Every day
- Estimated price
- $310–1,500
Flights from Louisville International Airport to Columbia via Chicago O'Hare
- Ave. Duration
- 5h 48m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $280–1,400
Flights from Blue Grass Airport to Columbia via Charlotte
- Ave. Duration
- 4h 18m
- When
- Every day
- Estimated price
- $200–1,300
Flights from Blue Grass Airport to Columbia via Chicago O'Hare
- Ave. Duration
- 4h 48m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $360–1,800
- Website
- delta.com
Flights from Louisville International Airport to Columbia via Atlanta
- Ave. Duration
- 3h 56m
- When
- Every day
- Estimated price
- $190–1,100
Flights from Blue Grass Airport to Columbia via Atlanta
- Ave. Duration
- 4h 25m
- When
- Every day
- Estimated price
- $230–1,400
- Website
- united.com
Flights from Louisville International Airport to Columbia via Washington Dulles
- Ave. Duration
- 4h 43m
- When
- Every day
- Estimated price
- $260–1,300
Flights from Louisville International Airport to Columbia via Chicago O'Hare
- Ave. Duration
- 6h 40m
- When
- Every day
- Estimated price
- $280–1,400
Flights from Blue Grass Airport to Columbia via Chicago O'Hare
- Ave. Duration
- 7h 11m
- When
- Every day
- Estimated price
- $360–1,800
Rome2Rio's guide to Amtrak Thruway
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Bus from Louisville, KY to Nashville
- Ave. Duration
- 3h
- Frequency
- Twice daily
- Estimated price
- $30–50
- Website
- https://www.amtrak.com/home.html
- Adult
- $30–50
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- greyhound.com
Bus from Nashville Bus Station to Atlanta Bus Station
- Ave. Duration
- 4h 30m
- Frequency
- Every 4 hours
- Estimated price
- $35–75
- Website
- https://www.greyhound.com/
Bus from Atlanta Bus Station to Camden
- Ave. Duration
- 5h
- Frequency
- Twice daily
- Estimated price
- $35–75
- Website
- https://www.greyhound.com/
Bus from Charlotte Bus Station to Camden
- Ave. Duration
- 1h 35m
- Frequency
- Once daily
- Estimated price
- $11–23
- Website
- https://www.greyhound.com/
- Phone
- +1 (855) 626-8585
- Website
- https://www.flixbus.com
Bus from Nashville Bus Station to Atlanta Bus Station
- Ave. Duration
- 4h
- Frequency
- Twice daily
- Estimated price
- $40–70
- Schedules at
- flixbus.com
- Phone
- +1 646-630-7186
- [email protected]
- Website
- wandacoach.com
Bus from Camden to Columbia, SC
- Ave. Duration
- 42 min
- Frequency
- Once daily
- Estimated price
- $28–40
- Website
- https://www.wandacoach.com
- Book at
- https://www.gotobus.com/wanda-travel/
- Adult One Way
- $28–40
Bus from Camden to Columbia, SC
- Ave. Duration
- 42 min
- Frequency
- Once daily
- Estimated price
- $28–40
- Website
- https://www.wandacoach.com
- Book at
- https://www.gotobus.com/wanda-travel/
- Adult One Way
- $28–40
- Phone
- +1 888-378-3823
- [email protected]
- Website
- baronsbus.com
Bus from Louisville, KY Bus Station to Columbus - Downtown - Mound St
- Ave. Duration
- 4h 25m
- Frequency
- Twice daily
- Estimated price
- $21–60
- Website
- https://baronsbus.com
Bus from Columbus - Mound St to Hurricane
- Ave. Duration
- 3h 45m
- Frequency
- Once daily
- Estimated price
- $15–55
- Website
- https://baronsbus.com
Bus from Hurricane to Charlotte Bus Station
- Ave. Duration
- 6h
- Frequency
- Once daily
- Estimated price
- $28–75
- Website
- https://baronsbus.com
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Why you should take the train in the US
Read the travel guide
Need to know: Greyhound
Read the travel guide
More Questions & Answers
There are 341+ hotels available in Lexington.








