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How to get fromLouisville to Mayo Clinicby plane, bus (Amtrak), bus, train, car, or bus (Amtrak, Greyhound, Flixbus)

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There are 8 ways to get from Louisville to Mayo Clinic by plane, bus (Amtrak), bus, train, car, or bus (Amtrak, Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Louisville International Airport to Rochester

    best
    1. Fly from Louisville International Airport (SDF) to Rochester (RST)plane plane SDF - RST
    6h 46m
    $83–483

  2. Bus

    1. Take the bus from Louisville, KY to Chicago Union Stationbus bus
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    16h 6m
    $125–187

  3. Bus, train

    1. Take the bus from Louisville, KY to Indianapolis Union Stationbus bus
    2. Take the train from Indianapolis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    4. Take the bus from St. Paul to Rochester, MNbus bus
    19h 29m
    $241–484

  4. Drive 640.9 mi

    1. Drive from Louisville to Mayo Cliniccar car 640.9 mi
    10h 46m
    $117–169

  5. Drive to Blue Grass Airport, fly to Rochester

    1. Drive from Louisville to Lexington-Airport-LEXcar car
    2. Fly from Blue Grass Airport (LEX) to Rochester (RST)plane plane LEX - RST
    6h 49m
    $114–609

  6. Fly Louisville International Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Louisville International Airport (SDF) to Minneapolis–Saint Paul International Airport (MSP)plane plane SDF - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    6h 28m
    $154–605

  7. Bus via Indianapolis

    1. Take the bus from Louisville, KY to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis Union Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Wisconsin Dellsbus bus
    4. Take the bus from Wisconsin Dells to Rochester, MNbus bus
    16h 38m
    $126–224

  8. Bus, train via Madison

    1. Take the bus from Louisville, KY to Indianapolis Union Stationbus bus
    2. Take the train from Indianapolis to Chicago Union Stationtrain train
    3. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    4. Take the bus from Madison to Rochesterbus bus
    18h 26m
    $158–304

Louisville to Mayo Clinic by bus, train, and foot

Calendar3Weekly Services
Duration19h 29mAverage Duration
Ticket$241Cheapest Price
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Questions & Answers

Map of how to get from Louisville to Mayo Clinic.ExpandLaunch map view
  • Distance: 544.7 mi
  • Duration: 6h 46m

What companies run services between Louisville, KY, USA and Mayo Clinic, MN, USA?

United Airlines, Delta, and American Airlines fly from Louisville International Airport (SDF) to Rochester (RST) every 4 hours. Alternatively, you can take a bus from Louisville, KY to Mayo Clinic via Chicago Union Station, W Jackson Blvd, after S Clinton St, Madison, and Rochester in around 16h 6m.

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