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How to get fromLouisville to Mayo Clinic Hospitalby plane, bus, train, car, or bus (Amtrak, Greyhound, Flixbus)

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There are 9 ways to get from Louisville to Mayo Clinic Hospital by plane, bus, train, car, or bus (Amtrak, Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Louisville International Airport to Rochester

    best
    1. Fly from Louisville International Airport (SDF) to Rochester (RST)plane plane SDF - RST
    7h 5m
    $83–483

  2. Bus, train

    1. Take the bus from Louisville, KY to Chicago Union Stationbus bus
    2. Take the train from Chicago Union Station to Milwaukeetrain train
    3. Take the bus from Milwaukee to Rochesterbus bus
    15h 29m
    $147–217

  3. Bus, train via Indianapolis

    1. Take the bus from Louisville, KY to Indianapolis Union Stationbus bus
    2. Take the train from Indianapolis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    4. Take the bus from St. Paul to Rochesterbus bus
    19h 36m
    $241–484

  4. Drive 641.5 mi

    1. Drive from Louisville to Mayo Clinic Hospitalcar car 641.5 mi
    10h 47m
    $118–170

  5. Fly Louisville International Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Louisville International Airport (SDF) to Minneapolis–Saint Paul International Airport (MSP)plane plane SDF - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    6h 31m
    $154–605

  6. Drive to Blue Grass Airport, fly to Rochester

    1. Drive from Louisville to Lexington-Airport-LEXcar car
    2. Fly from Blue Grass Airport (LEX) to Rochester (RST)plane plane LEX - RST
    7h 7m
    $114–609

  7. Bus to Covington, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the bus from Louisville, KY Bus Station to Cincinnati - Downtownbus bus
    2. Fly from Covington (CVG) to Minneapolis–Saint Paul International Airport (MSP)plane plane CVG - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    8h 32m
    $514–1,197

  8. Bus

    1. Take the bus from Louisville, KY to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis Union Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Madisonbus bus
    4. Take the bus from Madison to Rochesterbus bus
    17h 20m
    $126–224

  9. Bus, train via Indianapolis #2

    1. Take the bus from Louisville, KY to Indianapolis Union Stationbus bus
    2. Take the train from Indianapolis to Chicago Union Stationtrain train
    3. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    4. Take the bus from Madison to Rochesterbus bus
    18h 38m
    $158–304

Louisville International Airport (SDF) to Rochester (RST) flights

Calendar43Weekly Planes
Duration5h 15mAverage Duration
Ticket$79Cheapest Price
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Questions & Answers

Map of how to get from Louisville to Mayo Clinic Hospital.ExpandLaunch map view
  • Distance: 545 mi
  • Duration: 7h 5m

What companies run services between Louisville, KY, USA and Mayo Clinic Hospital, MN, USA?

United Airlines, Delta, and American Airlines fly from Louisville International Airport (SDF) to Rochester (RST) every 4 hours. Alternatively, you can take a bus from Louisville, KY to Mayo Clinic Hospital via Indianapolis Union Station, Chicago Bus Station, Madison, and Rochester in around 17h 20m.

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