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How to get fromLouisville to Mechanicsburgby plane, bus (Flixbus), car, train, or bus (Greyhound)

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There are 5 ways to get from Louisville to Mechanicsburg by plane, bus (Flixbus), car, train, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Harrisburg International Airport

    best
    1. Fly from Louisville International Airport (SDF) to Harrisburg International Airport (MDT)plane plane SDF - MDT
    6h 52m
    $79–437

  2. Bus via Columbus

    cheapest
    1. Take the bus from Louisville, KY Bus Station to N Wilson Rd & Ferrell Pl - Columbusbus bus Louisville
    2. Take the bus from Wilson & Ferrell Shell Station - Columbus to Harrisburg Bus Stationbus bus Greyhound US0421
    15h 59m
    $76–180

  3. Bus

    1. Take the bus from Louisville, KY Bus Station to Cincinnati - Downtownbus bus Louisville
    2. Take the bus from Cincinnati to Harrisburg Bus Stationbus bus FlixBus N2642
    15h 35m
    $93–191

  4. Drive 557.9 mi

    1. Drive from Louisville to Mechanicsburgcar car 557.9 mi
    9h 44m
    $102–148

  5. Fly to Philadelphia International Airport, train

    1. Fly from Louisville International Airport (SDF) to Philadelphia International Airport (PHL)plane plane SDF - PHL
    2. Take the train from 30th Street Station to Harrisburgtrain train
    8h 6m
    $146–678

Louisville to Mechanicsburg by bus and foot

Calendar5Weekly Services
Duration15h 35mAverage Duration
Ticket$93Cheapest Price
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Questions & Answers

Map of how to get from Louisville to Mechanicsburg.ExpandLaunch map view
  • Distance: 526.1 mi
  • Duration: 6h 52m

What companies run services between Louisville, KY, USA and Mechanicsburg, Cumberland County, PA, USA?

United Airlines, American Airlines, and Delta fly from Louisville International Airport (SDF) to Harrisburg International Airport (MDT) hourly. Alternatively, you can take a bus from Louisville, KY Bus Station to E Main St & Arch St WB via Cincinnati - Downtown, 9Th St & Race St, Northside Transit Center - Shelter B, Vine St & Martin Luther King Dr, Cincinnati, Harrisburg Bus Station, and Market Square Transfer Center in around 15h 35m.

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