What is the cheapest way to get from Louisville to Middlesboro?

The cheapest way to get from Louisville to Middlesboro is to drive which costs $30 - $50 and takes 4h 13m.

What is the fastest way to get from Louisville to Middlesboro?

The fastest way to get from Louisville to Middlesboro is to drive which takes 4h 13m and costs $30 - $50.

How far is it from Louisville to Middlesboro?

The distance between Louisville and Middlesboro is 332 miles. The road distance is 190.5 miles.

How long does it take to get from Louisville to Middlesboro?

It takes approximately 7h 56m to get from Louisville to Middlesboro, including transfers.

Can I drive from Louisville to Middlesboro?

Yes, the driving distance between Louisville to Middlesboro is 191 miles. It takes approximately 4h 13m to drive from Louisville to Middlesboro.

Where can I stay near Middlesboro?

There are 18+ hotels available in Middlesboro.

Louisville to Middlesboro - 4 ways to travel via bus, car, and plane

How to get fromLouisville to Middlesboro

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There are 4 ways to get from Louisville to Middlesboro by bus, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

Bus, drive
best
1. Take the bus from Louisville, KY Bus Station to Greyhound Station Cincinnatibus
2. Take the bus from Cincinnati Bus Station to Londonbus
3. Drive from London to Middlesborocar
7h 56m
$47–113
Drive 189.4 mi
cheapest
1. Drive from Louisville to Middlesborocar 189.4 mi
4h 13m
$35–50
Fly to Mcghee Tyson Airport, drive
1. Fly from Louisville International Airport (SDF) to Mcghee Tyson Airport (TYS)plane SDF - TYS
2. Drive from Mcghee Tyson Airport (TYS) to Middlesborocar
6h 38m
$115–723
Fly to Tri-Cities Regional Tn/Va Airport, drive
1. Fly from Louisville International Airport (SDF) to Tri-Cities Regional Tn/Va Airport (TRI)plane SDF - TRI
2. Drive from Tri-Cities-Regional-Airport-TRI to Middlesborocar
6h 54m
$109–579

Louisville International Airport (SDF) to Mcghee Tyson Airport (TYS) flights

109Weekly Planes

4h 33mAverage Duration

$107Cheapest Price

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Questions & Answers

Map of how to get from Louisville to Middlesboro.

Launch map view

Distance: 329.8 mi
Duration: 7h 56m

What companies run services between Louisville, KY, USA and Middlesboro, KY, USA?

There is no direct connection from Louisville to Middlesboro. However, you can take the bus to Greyhound Station Cincinnati, walk to Cincinnati Bus Station, take the bus to London, then drive to Middlesboro. Alternatively, you can drive from Louisville to Middlesboro in around 4h 13m.

Airlines

Bus operators

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How to get fromLouisville to Middlesboroby bus, car, or plane

There are 4 ways to get from Louisville to Middlesboro by bus, car, or plane

Bus, drive

Drive 189.4 mi

Fly to Mcghee Tyson Airport, drive

Fly to Tri-Cities Regional Tn/Va Airport, drive