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How to get fromLouisville to Middlesboroby plane, car, or bus

Find Transport to Middlesboro

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There are 4 ways to get from Louisville to Middlesboro by plane, car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Mcghee Tyson Airport, drive

    best
    1. Fly from Louisville International Airport (SDF) to Mcghee Tyson Airport (TYS)plane plane SDF - TYS
    2. Drive from Mcghee Tyson Airport (TYS) to Middlesborocar car
    6h 32m
    $155–973

  2. Drive  189.4 mi

    cheapest
    1. Drive from Louisville to Middlesborocar car 189.4 mi
    4h 13m
    $35–50

  3. Bus, drive

    1. Take the bus from Louisville, KY to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis to Cincinnatibus bus
    3. Take the bus from Cincinnati Bus Station to Londonbus bus
    4. Drive from London to Middlesborocar car
    12h 6m
    $75–153

  4. Fly to Tri-Cities Regional Tn/Va Airport, drive

    1. Fly from Louisville International Airport (SDF) to Tri-Cities Regional Tn/Va Airport (TRI)plane plane SDF - TRI
    2. Drive from Tri-Cities-Regional-Airport-TRI to Middlesborocar car
    6h 50m
    $89–469

Louisville International Airport (SDF) to Mcghee Tyson Airport (TYS) flights

Calendar79Weekly Planes
Duration4h 20mAverage Duration
Ticket$145Cheapest Price
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Comparing Your Travel Options

Map of how to get from Louisville to Middlesboro.ExpandLaunch map view
  • Distance: 270.5 mi
  • Duration: 6h 32m

What companies run services between Louisville, KY, USA and Middlesboro, KY, USA?

There is no direct connection from Louisville to Middlesboro. However, you can take the line 02 bus to Louisville International Airport, walk to Louisville International Airport (SDF) airport, fly to Mcghee Tyson Airport (TYS), then drive to Middlesboro. Alternatively, you can take a bus from Louisville, KY to Middlesboro via Indianapolis, Cincinnati, Cincinnati Bus Station, and London in around 12h 6m.

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