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How to get fromLouisville to Myrtle Beachby plane, bus (Amtrak, Greyhound, Flixbus), car, bus, or bus (Greyhound)

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There are 7 ways to get from Louisville to Myrtle Beach by plane, bus (Amtrak, Greyhound, Flixbus), car, bus, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Louisville International Airport

    best
    1. Fly from Louisville International Airport (SDF) to Myrtle Beach (MYR)plane plane SDF - MYR
    4h 54m
    $78–397

  2. Drive to Blue Grass Airport, fly

    cheapest
    1. Drive from Louisville to Lexington-Airport-LEXcar car
    2. Fly from Blue Grass Airport (LEX) to Myrtle Beach (MYR)plane plane LEX - MYR
    5h 2m
    $74–333

  3. Bus via Atlanta

    1. Take the bus from Louisville, KY to Nashvillebus bus
    2. Take the bus from Nashville Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Myrtle Beach Bus Stationbus bus
    18h 10m
    $113–211

  4. Drive 609.3 mi

    1. Drive from Louisville to Myrtle Beachcar car 609.3 mi
    12h 31m
    $112–161

  5. Bus to Covington, fly

    1. Take the bus from Louisville, KY Bus Station to Cincinnati - Downtownbus bus
    2. Fly from Covington (CVG) to Myrtle Beach (MYR)plane plane CVG - MYR
    5h 18m
    $463–709

  6. Bus to Nashville, fly

    1. Take the bus from Louisville, KY to Nashvillebus bus
    2. Fly from Nashville (BNA) to Myrtle Beach (MYR)plane plane BNA - MYR
    6h 15m
    $106–422

  7. Bus

    1. Take the bus from Louisville, KY Bus Station to Columbus - Downtown - Mound Stbus bus
    2. Take the bus from Columbus - Mound St to Hurricanebus bus
    3. Take the bus from Hurricane to Charlotte Bus Stationbus bus
    4. Take the bus from Charlotte Bus Station to Camdenbus bus
    5. Take the bus from Camden to Myrtle Beach Bus Stationbus bus
    23h 5m
    $91–245

Louisville to Myrtle Beach by bus

Calendar7Weekly Buses
Duration18h 10mAverage Duration
Ticket$113Cheapest Price
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Questions & Answers

Map of how to get from Louisville to Myrtle Beach.ExpandLaunch map view
  • Distance: 501.3 mi
  • Duration: 4h 54m

What companies run services between Louisville, KY, USA and Myrtle Beach, SC, USA?

Southwest Airlines, American Airlines, and Delta fly from Louisville International Airport (SDF) to Myrtle Beach (MYR) every 4 hours. Alternatively, you can take a bus from Louisville, KY to Myrtle Beach Bus Station via Nashville Bus Station and Atlanta Bus Station in around 18h 10m.

Airlines
Bus operators

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