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How to get fromLouisville to Opelikaby plane, taxi, bus (Amtrak, Greyhound), car, bus, or bus (Amtrak, Greyhound, Flixbus)

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There are 9 ways to get from Louisville to Opelika by plane, taxi, bus (Amtrak, Greyhound), car, bus, or bus (Amtrak, Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Louisville International Airport to Columbus Airport, taxi

    best
    1. Fly from Louisville International Airport (SDF) to Columbus Airport (CSG)plane plane SDF - CSG
    2. Take the taxi from Columbus Airport (CSG) to Opelikataxi taxi
    5h 23m
    $137–508

  2. Drive  476.5 mi

    cheapest
    1. Drive from Louisville to Opelikacar car 476.5 mi
    8h 2m
    $87–126

  3. Bus

    1. Take the bus from Louisville, KY to Nashvillebus bus
    2. Take the bus from Nashville Bus Station to Montgomery Intermodal Centerbus bus
    3. Take the bus from Montgomery Intermodal Center to Opelika 4th Street Stationbus bus
    11h 10m
    $89–138

  4. Fly Louisville International Airport to Hartsfield-Jackson Atlanta International Airport, bus

    1. Fly from Louisville International Airport (SDF) to Hartsfield-Jackson Atlanta International Airport (ATL)plane plane SDF - ATL
    2. Take the bus from Atlanta Airport to Comfort Inn - Opelikabus bus
    5h 28m
    $117–545

  5. Drive to Blue Grass Airport, fly to Hartsfield-Jackson Atlanta International Airport, bus

    1. Drive from Louisville to Lexington-Airport-LEXcar car
    2. Fly from Blue Grass Airport (LEX) to Hartsfield-Jackson Atlanta International Airport (ATL)plane plane LEX - ATL
    3. Take the bus from Atlanta Airport to Comfort Inn - Opelikabus bus
    5h 23m
    $113–471

  6. Drive to Covington, fly to Hartsfield-Jackson Atlanta International Airport, bus

    1. Drive from Louisville to Covington (CVG)car car
    2. Fly from Covington (CVG) to Hartsfield-Jackson Atlanta International Airport (ATL)plane plane CVG - ATL
    3. Take the bus from Atlanta Airport to Comfort Inn - Opelikabus bus
    5h 44m
    $232–1,047

  7. Bus via Sandy Springs

    1. Take the bus from Louisville, KY to Nashvillebus bus
    2. Take the bus from Nashville Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta to Opelika 4th Street Stationbus bus
    11h 51m
    $116–179

  8. Bus via Atlanta

    1. Take the bus from Louisville, KY to Nashvillebus bus
    2. Take the bus from Nashville Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Opelika 4th Street Stationbus bus
    12h 15m
    $92–151

  9. Bus via Chattanooga

    1. Take the bus from Louisville, KY to Nashvillebus bus
    2. Take the bus from Nashville Airport to Groome Transportation Chattanoogabus bus
    3. Take the bus from Groome Transportation Chattanooga to Atlanta Airportbus bus
    4. Take the bus from Atlanta Airport to Opelika 4th Street Stationbus bus
    13h 34m
    $148–193

Louisville to Opelika by bus

Calendar14Weekly Buses
Duration11h 10mAverage Duration
Ticket$89Cheapest Price
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Comparing Your Travel Options

Map of how to get from Louisville to Opelika.ExpandLaunch map view
  • Distance: 431.7 mi
  • Duration: 5h 23m

What companies run services between Louisville, KY, USA and Opelika, AL, USA?

You can take a bus from Louisville, KY to Opelika 4th Street Station via Nashville Bus Station and Montgomery Intermodal Center in around 11h 10m.

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