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How to get fromLouisville to Panama City Beachby plane, bus (Amtrak, Greyhound), car, bus, or bus (Greyhound)

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There are 7 ways to get from Louisville to Panama City Beach by plane, bus (Amtrak, Greyhound), car, bus, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Louisville International Airport to Northwest Florida Beaches International Airport

    best
    1. Fly from Louisville International Airport (SDF) to Northwest Florida Beaches International Airport (ECP)plane plane SDF - ECP
    5h 11m
    $132–508

  2. Fly Louisville International Airport to Destin–Fort Walton Beach Airport, drive

    cheapest
    1. Fly from Louisville International Airport (SDF) to Destin–Fort Walton Beach Airport (VPS)plane plane SDF - VPS
    2. Drive from Destin–Fort Walton Beach Airport (VPS) to Panama City Beachcar car
    4h 32m
    $87–449

  3. Bus

    1. Take the bus from Louisville, KY to Nashvillebus bus
    2. Take the bus from Nashville Bus Station to Tallahasseebus bus
    3. Take the bus from Tallahassee to Panama City Beach Bus Stationbus bus
    16h 39m
    $127–228

  4. Drive 630.4 mi

    1. Drive from Louisville to Panama City Beachcar car 630.4 mi
    11h 6m
    $115–167

  5. Drive to Blue Grass Airport, fly to Destin–Fort Walton Beach Airport, drive

    1. Drive from Louisville to Lexington-Airport-LEXcar car
    2. Fly from Blue Grass Airport (LEX) to Destin–Fort Walton Beach Airport (VPS)plane plane LEX - VPS
    3. Drive from Destin–Fort Walton Beach Airport (VPS) to Panama City Beachcar car
    6h 18m
    $123–585

  6. Bus to Nashville, fly to Northwest Florida Beaches International Airport

    1. Take the bus from Louisville, KY to Nashvillebus bus
    2. Fly from Nashville (BNA) to Northwest Florida Beaches International Airport (ECP)plane plane BNA - ECP
    6h 27m
    $150–503

  7. Bus via Preston @ Park Brook

    1. Take the bus from La Tropicana - Louisville, KY to Tornado Bus Co - Nashvillebus bus
    2. Take the bus from Nashville Bus Station to Tallahasseebus bus
    3. Take the bus from Tallahassee to Panama City Beach Bus Stationbus bus
    19h 11m
    $150–339

Louisville International Airport (SDF) to Northwest Florida Beaches International Airport (ECP) flights

Calendar73Weekly Planes
Duration4h 51mAverage Duration
Ticket$79Cheapest Price
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Questions & Answers

Map of how to get from Louisville to Panama City Beach.ExpandLaunch map view
  • Distance: 566.3 mi
  • Duration: 5h 11m

What companies run services between Louisville, KY, USA and Panama City Beach, FL, USA?

Southwest Airlines, Delta, and American Airlines fly from Louisville International Airport (SDF) to Northwest Florida Beaches International Airport (ECP) every 3 hours. Alternatively, you can take a bus from Louisville, KY to Panama City Beach via Nashville Bus Station, Tallahassee, and Panama City Beach Bus Station in around 16h 39m.

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