There are 3 ways to get from Louisville to Pittsburgh by plane, bus, bus (Amtrak, Greyhound), or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly, bus
best- Fly from Louisville International Airport (SDF) to Pittsburgh International Airport (PIT)plane SDF - PIT
- Take the bus from Pittsburgh International Airport to Seventh Ave + William Penn Plbus
4h 16mDrive 385.1 mi
cheapest- Drive from Louisville to Pittsburghcar 385.1 mi
6h 36m$68–99Bus
- Take the bus from Louisville, KY to Indianapolis Union Stationbus Nashville
- Take the bus from Indianapolis Union Station to Pittsburgh Intermodal Stationbus Greyhound US0421
12h 10m$88–144
Louisville to Pittsburgh by bus
Comparing Your Travel Options
The cheapest way to get from Louisville to Pittsburgh is to drive which costs $65 - $100 and takes 6h 36m.
The fastest way to get from Louisville to Pittsburgh is to drive which takes 6h 36m and costs $65 - $100.
No, there is no direct bus from Louisville to Pittsburgh station. However, there are services departing from Louisville, KY and arriving at Pittsburgh Intermodal Station via Indianapolis Union Station. The journey, including transfers, takes approximately 12h 10m.
The distance between Louisville and Pittsburgh is 368 miles. The road distance is 387.3 miles.
The best way to get from Louisville to Pittsburgh without a car is to bus which takes 12h 10m and costs $85 - $150.
It takes approximately 4h 16m to get from Louisville to Pittsburgh, including transfers.
Louisville to Pittsburgh bus services, operated by Amtrak Thruway, depart from Louisville, KY station.
Louisville to Pittsburgh bus services, operated by Amtrak Thruway, arrive at Indianapolis Union Station.
Yes, the driving distance between Louisville to Pittsburgh is 387 miles. It takes approximately 6h 36m to drive from Louisville to Pittsburgh.
Book your Louisville to Pittsburgh bus tickets online with Omio.
What companies run services between Louisville, KY, USA and Pittsburgh, PA, USA?
You can take a bus from Louisville, KY to Pittsburgh Intermodal Station via Indianapolis Union Station in around 12h 10m.
- Website
- flybreeze.com
Flights from Louisville International Airport to Pittsburgh International Airport
- Ave. Duration
- 1h 20m
- When
- Monday and Friday
- Estimated price
- $210–1,300
- Website
- southwest.com
Flights from Louisville International Airport to Pittsburgh International Airport via Nashville
- Ave. Duration
- 3h 25m
- When
- Monday, Thursday, Friday, and Sunday
- Estimated price
- $100–600
- Website
- delta.com
Flights from Louisville International Airport to Pittsburgh International Airport via Detroit
- Ave. Duration
- 3h 40m
- When
- Every day
- Estimated price
- $95–600
- Phone
- +1 412-442-2000
- Website
- Pittsburgh Regional Transit
Bus from Pittsburgh International Airport to Seventh Ave + William Penn Pl
- Ave. Duration
- 40 min
- Frequency
- Every 30 minutes
- Website
- Pittsburgh Regional Transit
Rome2Rio's guide to Amtrak Thruway
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Bus from Louisville, KY to Indianapolis Union Station
- Ave. Duration
- 2h 20m
- Frequency
- Twice daily
- Estimated price
- $22–45
- Website
- Amtrak
- Adult
- $22–45
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Indianapolis Union Station to Pittsburgh Intermodal Station
- Ave. Duration
- 8h 50m
- Frequency
- 3 times a day
- Estimated price
- $65–100
- Website
- Greyhound
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Why you should take the train in the US
Read the travel guide
Need to know: Greyhound
Read the travel guide
Booking & Getting There
There are 730+ hotels available in Pittsburgh.



