There are 10 ways to get from Louisville to Rochester by plane, bus, train, car, bus (Amtrak, Greyhound), or bus (Amtrak, Greyhound, Flixbus)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Louisville International Airport to Rochester
best- Fly from Louisville International Airport (SDF) to Rochester (ROC)plane SDF - ROC
5h 23m$187–1,022Bus via Toledo
cheapest- Take the bus from Louisville, KY to Indianapolis Union Stationbus
- Take the bus from Indianapolis to Toledobus
- Take the bus from Toledo Bus Stop to Cleveland Bus Stationbus
- Take the bus from Cleveland Bus Station to Rochester Bus Stopbus
16h 10m$107–211Bus, train via Toledo
- Take the bus from Louisville, KY to Indianapolis Union Stationbus
- Take the bus from Indianapolis to Toledobus
- Take the train from Toledo to Rochestertrain
14h 44m$234–419Bus, train
- Take the bus from Louisville, KY to Indianapolis Union Stationbus
- Take the bus from Indianapolis Union Station to Toledo Bus Stopbus
- Take the train from Toledo to Rochestertrain
15h 9m$248–414Drive 595.3 mi
- Drive from Louisville to Rochestercar 595.3 mi
10h 22m$109–157Drive to Covington, fly to Rochester
- Drive from Louisville to Covington (CVG)car
- Fly from Covington (CVG) to Rochester (ROC)plane CVG - ROC
5h 24m$222–1,244Drive to Blue Grass Airport, fly to Rochester
- Drive from Louisville to Lexington-Airport-LEXcar
- Fly from Blue Grass Airport (LEX) to Rochester (ROC)plane LEX - ROC
5h 25m$158–838Fly Louisville International Airport to Buffalo Niagara International Airport, bus
- Fly from Louisville International Airport (SDF) to Buffalo Niagara International Airport (BUF)plane SDF - BUF
- Take the bus from Buffalo Niagara International Airport to Rochester Bus Stopbus
7h 18m$132–718Bus
- Take the bus from Louisville, KY to Indianapolis Union Stationbus
- Take the bus from Indianapolis Union Station to Columbusbus
- Take the bus from Columbus to Buffalobus
- Take the bus from Buffalo to Rochesterbus 325
18h 39m$124–227Bus, train #2 (Amtrak)
- Take the bus from Louisville, KY to Indianapolis Union Stationbus
- Take the train from Indianapolis to Chicago Union Stationtrain
- Take the train from Chicago Union Station to Rochestertrain
20h 50m$443–714
Louisville to Rochester by bus and train
Comparing Your Travel Options
The cheapest way to get from Louisville to Rochester is to drive which costs $100 - $160 and takes 10h 22m.
The fastest way to get from Louisville to Rochester is to fly which takes 5h 23m and costs $180 - $1,100.
No, there is no direct bus from Louisville to Rochester. However, there are services departing from Louisville, KY and arriving at Rochester Bus Stop via Indianapolis, Toledo Bus Stop and Cleveland Bus Station. The journey, including transfers, takes approximately 16h 10m.
The distance between Louisville and Rochester is 557 miles. The road distance is 598.8 miles.
The best way to get from Louisville to Rochester without a car is to bus and train via Toledo which takes 14h 44m and costs $230 - $420.
It takes approximately 5h 23m to get from Louisville to Rochester, including transfers.
Louisville to Rochester bus services, operated by Amtrak Thruway, depart from Louisville, KY station.
The best way to get from Louisville to Rochester is to fly which takes 5h 23m and costs $180 - $1,100. Alternatively, you can bus via Toledo, which costs $100 - $220 and takes 16h 10m.
Louisville to Rochester bus services, operated by Amtrak Thruway, arrive at Indianapolis Union Station.
Yes, the driving distance between Louisville to Rochester is 599 miles. It takes approximately 10h 22m to drive from Louisville to Rochester.
What companies run services between Louisville, KY, USA and Rochester, NY, USA?
Delta, Southwest Airlines, and two other airlines fly from Louisville International Airport (SDF) to Rochester (ROC) hourly. Alternatively, you can take a bus from Louisville, KY to Rochester Bus Stop via Indianapolis, Toledo Bus Stop, and Cleveland Bus Station in around 16h 10m.
- Website
- aa.com
Flights from Louisville International Airport to Rochester via Philadelphia
- Ave. Duration
- 6h 11m
- When
- Every day
- Estimated price
- $200–1,100
Flights from Louisville International Airport to Rochester via Reagan Washington
- Ave. Duration
- 6h 18m
- When
- Monday to Saturday
- Estimated price
- $190–1,100
Flights from Louisville International Airport to Rochester via Charlotte
- Ave. Duration
- 5h 58m
- When
- Every day
- Estimated price
- $220–1,100
Flights from Covington to Rochester via Philadelphia
- Ave. Duration
- 4h 41m
- When
- Every day
- Estimated price
- $240–1,300
Flights from Covington to Rochester via Reagan Washington
- Ave. Duration
- 5h 21m
- When
- Every day
- Estimated price
- $230–1,300
Flights from Blue Grass Airport to Rochester via Philadelphia
- Ave. Duration
- 5h 50m
- When
- Saturday, Wednesday, Friday, and Sunday
- Estimated price
- $160–850
Flights from Blue Grass Airport to Rochester via Charlotte
- Ave. Duration
- 6h 1m
- When
- Every day
- Estimated price
- $170–900
Flights from Blue Grass Airport to Rochester via Chicago O'Hare
- Ave. Duration
- 6h 25m
- When
- Every day
- Estimated price
- $170–900
Flights from Louisville International Airport to Buffalo Niagara International Airport via Reagan Washington
- Ave. Duration
- 6h 15m
- When
- Every day
- Estimated price
- $140–800
Flights from Louisville International Airport to Buffalo Niagara International Airport via Charlotte
- Ave. Duration
- 6h 14m
- When
- Every day
- Estimated price
- $150–800
- Website
- southwest.com
Flights from Louisville International Airport to Rochester via Baltimore
- Ave. Duration
- 6h 1m
- When
- Every day
- Estimated price
- $190–1,100
Flights from Louisville International Airport to Rochester via Chicago Midway
- Ave. Duration
- 6h 15m
- When
- Monday, Thursday, Friday, Sunday, Tuesday, and Wednesday
- Estimated price
- $200–1,100
Flights from Covington to Rochester via Baltimore
- Ave. Duration
- 6h 18m
- When
- Saturday, Sunday, Tuesday, and Wednesday
- Estimated price
- $230–1,300
Flights from Covington to Rochester via Chicago Midway
- Ave. Duration
- 7h 7m
- When
- Sunday, Tuesday, and Wednesday
- Estimated price
- $240–1,300
Flights from Louisville International Airport to Buffalo Niagara International Airport via Baltimore
- Ave. Duration
- 5h 19m
- When
- Every day
- Estimated price
- $140–800
Flights from Louisville International Airport to Buffalo Niagara International Airport via Chicago Midway
- Ave. Duration
- 6h 8m
- When
- Monday, Thursday, Friday, Sunday, Tuesday, and Wednesday
- Estimated price
- $140–750
Flights from Louisville International Airport to Buffalo Niagara International Airport via Nashville
- Ave. Duration
- 6h 10m
- When
- Saturday and Sunday
- Estimated price
- $140–800
- Website
- delta.com
Flights from Louisville International Airport to Rochester via Detroit
- Ave. Duration
- 4h 41m
- When
- Every day
- Estimated price
- $170–1,000
Flights from Covington to Rochester via Detroit
- Ave. Duration
- 4h 9m
- When
- Every day
- Estimated price
- $190–1,200
Flights from Covington to Rochester via New York La Guardia
- Ave. Duration
- 5h 9m
- When
- Every day
- Estimated price
- $250–1,400
Flights from Blue Grass Airport to Rochester via Detroit
- Ave. Duration
- 4h 42m
- When
- Every day
- Estimated price
- $130–800
Flights from Blue Grass Airport to Rochester via New York La Guardia
- Ave. Duration
- 6h 5m
- When
- Every day
- Estimated price
- $170–900
Flights from Blue Grass Airport to Rochester via Atlanta
- Ave. Duration
- 6h 3m
- When
- Every day
- Estimated price
- $190–950
Flights from Louisville International Airport to Buffalo Niagara International Airport via Detroit
- Ave. Duration
- 4h 26m
- When
- Every day
- Estimated price
- $120–700
- Website
- united.com
Flights from Louisville International Airport to Rochester via Washington Dulles
- Ave. Duration
- 4h 16m
- When
- Monday, Wednesday, Thursday, Friday, Sunday, and Tuesday
- Estimated price
- $190–1,100
Flights from Covington to Rochester via Washington Dulles
- Ave. Duration
- 3h 59m
- When
- Every day
- Estimated price
- $220–1,300
Flights from Blue Grass Airport to Rochester via Chicago O'Hare
- Ave. Duration
- 5h 26m
- When
- Every day
- Estimated price
- $170–900
Flights from Louisville International Airport to Buffalo Niagara International Airport via Washington Dulles
- Ave. Duration
- 4h 22m
- When
- Every day
- Estimated price
- $140–750
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Toledo to Rochester
- Ave. Duration
- 6h 29m
- Frequency
- Twice daily
- Estimated price
- $190–310
- Website
- Amtrak
Train from Toledo to Rochester
- Ave. Duration
- 6h 29m
- Frequency
- Twice daily
- Estimated price
- $190–310
- Website
- Amtrak
Train from Indianapolis to Chicago Union Station
- Ave. Duration
- 5h
- Frequency
- 3 times a week
- Estimated price
- $100–170
- Website
- Amtrak
Train from Chicago Union Station to Rochester
- Ave. Duration
- 11h 30m
- Frequency
- Twice daily
- Estimated price
- $320–500
- Website
- Amtrak
Rome2Rio's guide to Amtrak Thruway
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Bus from Louisville, KY to Indianapolis Union Station
- Ave. Duration
- 2h 20m
- Frequency
- Twice daily
- Estimated price
- $22–45
- Website
- Amtrak
- Adult
- $22–45
Bus from Louisville, KY to Indianapolis Union Station
- Ave. Duration
- 2h 20m
- Frequency
- Twice daily
- Estimated price
- $22–45
- Website
- Amtrak
- Adult
- $22–45
Bus from Louisville, KY to Indianapolis Union Station
- Ave. Duration
- 2h 20m
- Frequency
- Twice daily
- Estimated price
- $22–45
- Website
- Amtrak
- Adult
- $22–45
Bus from Louisville, KY to Indianapolis Union Station
- Ave. Duration
- 2h 20m
- Frequency
- Twice daily
- Estimated price
- $22–45
- Website
- Amtrak
- Adult
- $22–45
Bus from Louisville, KY to Indianapolis Union Station
- Ave. Duration
- 2h 20m
- Frequency
- Twice daily
- Estimated price
- $22–45
- Website
- Amtrak
- Adult
- $22–45
- Phone
- +1 888-378-3823
- [email protected]
- Website
- Barons Bus
Bus from Indianapolis to Toledo
- Ave. Duration
- 3h 55m
- Frequency
- Once daily
- Estimated price
- $21–65
- Website
- Barons Bus
Bus from Indianapolis to Toledo
- Ave. Duration
- 3h 55m
- Frequency
- Once daily
- Estimated price
- $21–65
- Website
- Barons Bus
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Indianapolis Union Station to Toledo Bus Stop
- Ave. Duration
- 4h 20m
- Frequency
- Once daily
- Estimated price
- $35–60
- Website
- Greyhound
Bus from Toledo Bus Stop to Cleveland Bus Station
- Ave. Duration
- 1h 45m
- Frequency
- 4 times a day
- Estimated price
- $18–27
- Website
- Greyhound
Bus from Cleveland Bus Station to Rochester Bus Stop
- Ave. Duration
- 5h 10m
- Frequency
- Once daily
- Estimated price
- $45–75
- Website
- Greyhound
Bus from Indianapolis Union Station to Columbus
- Ave. Duration
- 5h 5m
- Frequency
- 3 times a day
- Estimated price
- $30–50
- Website
- Greyhound
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Buffalo Niagara International Airport to Rochester Bus Stop
- Ave. Duration
- 1h 10m
- Frequency
- Every 4 hours
- Estimated price
- $10–15
- Schedules at
- Flixbus USA
Bus from Columbus to Buffalo
- Ave. Duration
- 6h 25m
- Frequency
- Once daily
- Estimated price
- $50–80
- Schedules at
- Flixbus USA
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