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How to get fromLouisville to Saint Charlesby bus (Greyhound), car, plane, or bus

Find Transport to Saint Charles

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There are 5 ways to get from Louisville to Saint Charles by bus (Greyhound), car, plane, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Louisville, KY to Evansville, INbus bus Louisville / ...
    2. Take the bus from Evansville Bus Station to St Louis Bus Stationbus bus Greyhound US0186 / ...
    8h 5m
    $68–105

  2. Drive 280.1 mi

    cheapest
    1. Drive from Louisville to Saint Charlescar car 280.1 mi
    4h 41m
    $52–74

  3. Fly from Louisville International Airport

    1. Fly from Louisville International Airport (SDF) to Lambert–St. Louis International Airport (STL)plane plane SDF - STL
    6h
    $106–607

  4. Bus to Nashville, fly

    1. Take the bus from Louisville Bus Station to Nashville Bus Stationbus bus
    2. Fly from Nashville (BNA) to Lambert–St. Louis International Airport (STL)plane plane BNA - STL
    6h 51m
    $114–529

  5. Bus to Covington, fly

    1. Take the bus from Louisville, KY Bus Station to Cincinnati - Downtownbus bus
    2. Fly from Covington (CVG) to Lambert–St. Louis International Airport (STL)plane plane CVG - STL
    8h 4m
    $136–749

Louisville to Saint Charles by bus and train

Calendar14Weekly Services
Duration8h 5mAverage Duration
Ticket$68Cheapest Price
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Questions & Answers

Map of how to get from Louisville to Saint Charles.ExpandLaunch map view
  • Distance: 308.2 mi
  • Duration: 8h 5m

What companies run services between Louisville, KY, USA and Saint Charles, MO, USA?

You can take a bus from Louisville, KY to 4375 Rider Trail North Sb via Evansville Bus Station, St Louis Bus Station, CIVIC CENTER station, NORTH HANLEY station, and North Hanley Transit Center in around 8h 5m. Alternatively, Southwest Airlines, United Airlines, and two other airlines fly from Louisville International Airport (SDF) to Lambert–St. Louis International Airport (STL) hourly.

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