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How to get fromLouisville to Saint Charlesby bus, train, car, plane, or bus (Amtrak)

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There are 9 ways to get from Louisville to Saint Charles by bus, train, car, plane, or bus (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, train

    best
    1. Take the bus from Louisville, KY to Chicago Union Stationbus bus
    2. Take the train from Chicago OTC to Genevatrain train Up-W
    8h 3m
    $70–82

  2. Drive 322.9 mi

    cheapest
    1. Drive from Louisville to Saint Charlescar car 322.9 mi
    5h 57m
    $59–86

  3. Bus, train via Indianapolis

    1. Take the bus from Louisville, KY to Indianapolis Union Stationbus bus
    2. Take the train from Indianapolis to Chicago Union Stationtrain train
    3. Take the train from Chicago OTC to Genevatrain train
    10h 17m
    $103–199

  4. Fly Louisville International Airport to Chicago O'Hare International Airport, bus

    1. Fly from Louisville International Airport (SDF) to Chicago O'Hare International Airport (ORD)plane plane SDF - ORD
    2. Take the bus from Rosemont CTA Station to Elgin Transportation Center Bay 4bus bus
    4h 52m
    $81–377

  5. Bus, train via Indianapolis #2

    1. Take the bus from Louisville, KY to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis Union Station to Chicago Bus Stationbus bus
    3. Take the train from Chicago OTC to Genevatrain train
    9h 25m
    $70–124

  6. Bus

    1. Take the bus from Louisville, KY to Lafayette Amtrak Stationbus bus
    2. Take the bus from Purdue Memorial Union to O'Hare Multi-Modal Facilitybus bus
    3. Take the bus from Rosemont CTA Station to Elgin Transportation Center Bay 4bus bus 603
    9h 27m
    $122–172

  7. Fly Louisville International Airport to Chicago Midway International Airport, train

    1. Fly from Louisville International Airport (SDF) to Chicago Midway International Airport (MDW)plane plane SDF - MDW
    2. Take the train from Chicago OTC to Genevatrain train
    5h 21m
    $76–400

  8. Drive to Blue Grass Airport, fly to Chicago O'Hare International Airport, bus

    1. Drive from Louisville to Lexington-Airport-LEXcar car
    2. Fly from Blue Grass Airport (LEX) to Chicago O'Hare International Airport (ORD)plane plane LEX - ORD
    3. Take the bus from Rosemont CTA Station to Elgin Transportation Center Bay 4bus bus
    4h 50m
    $107–473

  9. Bus to Covington, fly to Chicago O'Hare International Airport, bus

    1. Take the bus from Louisville, KY Bus Station to Cincinnati - Downtownbus bus
    2. Fly from Covington (CVG) to Chicago O'Hare International Airport (ORD)plane plane CVG - ORD
    3. Take the bus from Rosemont CTA Station to Elgin Transportation Center Bay 4bus bus
    6h 56m
    $196–949

Louisville International Airport (SDF) to Chicago O'Hare International Airport (ORD) flights

Calendar77Weekly Planes
Duration2h 10mAverage Duration
Ticket$48Cheapest Price
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Questions & Answers

Map of how to get from Louisville to Saint Charles.ExpandLaunch map view
  • Distance: 338.6 mi
  • Duration: 8h 3m

What companies run services between Louisville, KY, USA and Saint Charles, IL, USA?

You can take a bus from Louisville, KY to Saint Charles via Lafayette Amtrak Station, Columbia St & 2nd St, Purdue Memorial Union, O'Hare Multi-Modal Facility, O'Hare MMF Bay 8, Rosemont CTA Station, and Elgin Transportation Center Bay 4 in around 9h 27m.

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Bus operators

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