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How to get fromLouisville to Saint Louis Countyby bus (Greyhound), car, plane, or bus

Find Transport to Saint Louis County

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There are 5 ways to get from Louisville to Saint Louis County by bus (Greyhound), car, plane, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Louisville, KY to Evansville, INbus bus Louisville
    2. Take the bus from Evansville Bus Station to St Louis Bus Stationbus bus Greyhound US0186 / ...
    8h 18m
    $66–105

  2. Drive 273.1 mi

    cheapest
    1. Drive from Louisville to Saint Louis Countycar car 273.1 mi
    4h 31m
    $50–72

  3. Fly from Louisville International Airport

    1. Fly from Louisville International Airport (SDF) to Lambert–St. Louis International Airport (STL)plane plane SDF - STL
    6h 18m
    $101–607

  4. Bus to Nashville, fly

    1. Take the bus from Louisville, KY to Nashvillebus bus
    2. Fly from Nashville (BNA) to Lambert–St. Louis International Airport (STL)plane plane BNA - STL
    7h 14m
    $119–752

  5. Bus to Covington, fly

    1. Take the bus from Louisville, KY Bus Station to Cincinnati - Downtownbus bus
    2. Fly from Covington (CVG) to Lambert–St. Louis International Airport (STL)plane plane CVG - STL
    8h 21m
    $616–999

Louisville to Saint Louis County by bus and train

Calendar7Weekly Services
Duration8h 18mAverage Duration
Ticket$66Cheapest Price
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Questions & Answers

Map of how to get from Louisville to Saint Louis County.ExpandLaunch map view
  • Distance: 300.9 mi
  • Duration: 8h 18m

What companies run services between Louisville, KY, USA and Saint Louis County, MO, USA?

You can take a bus from Louisville, KY to Clayton @ Devondale Place Wb via Evansville Bus Station, St Louis Bus Station, CIVIC CENTER station, CLAYTON station, and Clayton Transit Center in around 8h 18m. Alternatively, Southwest Airlines, United Airlines, and two other airlines fly from Louisville International Airport (SDF) to Lambert–St. Louis International Airport (STL) hourly.

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