Rome2Rio

How to get fromLouisville to Saint Louisby plane, taxi, bus, train, car, bus (Amtrak), or bus (Amtrak, Greyhound)

Find Transport to Saint Louis

See all options

There are 7 ways to get from Louisville to Saint Louis by plane, taxi, bus, train, car, bus (Amtrak), or bus (Amtrak, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Mbs International Airport, taxi

    best
    1. Fly from Louisville International Airport (SDF) to Mbs International Airport (MBS)plane plane SDF - MBS
    2. Take the taxi from Mbs International Airport (MBS) to Saint Louistaxi taxi
    6h 37m
    $112–468

  2. Drive 394.1 mi

    cheapest
    1. Drive from Louisville to Saint Louiscar car 394.1 mi
    7h 8m
    $72–104

  3. Bus, train

    1. Take the bus from Louisville, KY to Chicago Union Stationbus bus
    2. Take the train from Chicago Union Station to East Lansing Amtrak Stationtrain train
    3. Take the bus from East Lansing, MI to Alma, MIbus bus
    13h 30m
    $131–236

  4. Bus, train via Indianapolis

    1. Take the bus from Louisville, KY to Indianapolis Union Stationbus bus
    2. Take the train from Indianapolis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to East Lansing Amtrak Stationtrain train
    4. Take the bus from East Lansing, MI to Alma, MIbus bus
    15h 50m
    $164–353

  5. Fly to Capital Region International Airport, bus

    1. Fly from Louisville International Airport (SDF) to Capital Region International Airport (LAN)plane plane SDF - LAN
    2. Take the bus from Lansing, MI to Alma, MIbus bus
    7h 27m
    $135–793

  6. Bus

    1. Take the bus from Louisville, KY to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis, IN to Detroit, MIbus bus
    3. Take the bus from Detroit Greyhound to Alma, MIbus bus
    14h 10m
    $91–183

  7. Bus via Toledo

    1. Take the bus from Louisville, KY to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis Union Station to Toledo Bus Stopbus bus
    3. Take the bus from Toledo to East Lansing Amtrak Stationbus bus
    4. Take the bus from East Lansing, MI to Alma, MIbus bus
    14h 50m
    $129–228

Louisville International Airport (SDF) to Mbs International Airport (MBS) flights

Calendar23Weekly Planes
Duration4h 56mAverage Duration
Ticket$68Cheapest Price
See schedules

Questions & Answers

Map of how to get from Louisville to Saint Louis.ExpandLaunch map view
  • Distance: 419.9 mi
  • Duration: 6h 37m

What companies run services between Louisville, KY, USA and Saint Louis, MI, USA?

You can take a bus from Louisville, KY to Saint Louis via Indianapolis, IN, Detroit Greyhound, and Alma, MI in around 14h 10m.

Airlines
Train operators
Bus operators
Other operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound