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How to get fromLouisville to San Diegoby plane, bus (Greyhound, Flixbus), bus, train, or car

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There are 8 ways to get from Louisville to San Diego by plane, bus (Greyhound, Flixbus), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Louisville International Airport

    best
    1. Fly from Louisville International Airport (SDF) to San Diego International Airport (SAN)plane plane SDF - SAN
    7h 18m
    $192–803

  2. Bus

    1. Take the bus from Louisville, KY to Evansville, INbus bus
    2. Take the bus from Evansville Bus Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Los Angeles Union Stationbus bus
    4. Take the bus from Los Angeles Union Station to San Diegobus bus
    2d 4h
    $364–686

  3. Bus, train via Chicago (Amtrak)

    1. Take the bus from Louisville, KY to Chicago Union Stationbus bus
    2. Take the train from Chicago Union Station to Fullerton Amtrak Stationtrain train
    3. Take the train from Fullerton Amtrak Station to San Diegotrain train
    2d 5h
    $780–1,627

  4. Drive 2,056.6 mi

    1. Drive from Louisville to San Diegocar car 2,056.6 mi
    33h 24m
    $376–543

  5. Bus to Covington, fly

    1. Take the bus from Louisville, KY Bus Station to Cincinnati - Downtownbus bus
    2. Fly from Covington (CVG) to San Diego International Airport (SAN)plane plane CVG - SAN
    8h 28m
    $222–795

  6. Bus to Nashville, fly

    1. Take the bus from Louisville, KY to Nashvillebus bus
    2. Fly from Nashville (BNA) to San Diego International Airport (SAN)plane plane BNA - SAN
    8h 49m
    $215–848

  7. Bus to Indianapolis, fly

    1. Take the bus from Louisville, KY to Indianapolis Union Stationbus bus
    2. Fly from Indianapolis (IND) to San Diego International Airport (SAN)plane plane IND - SAN
    8h 55m
    $223–862

  8. Bus, train

    1. Take the bus from Louisville, KY to Evansville, INbus bus
    2. Take the bus from Evansville Bus Station to St Louis Bus Stationbus bus
    3. Take the train from St. Louis to Los Angelestrain train
    4. Take the train from Los Angeles to San Diegotrain train
    2d 22h
    $853–1,786

Louisville to San Diego by bus

Calendar7Weekly Buses
Duration2d 4hAverage Duration
Ticket$364Cheapest Price
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Questions & Answers

Map of how to get from Louisville to San Diego.ExpandLaunch map view
  • Distance: 1,807.3 mi
  • Duration: 7h 18m

What companies run services between Louisville, KY, USA and San Diego, CA, USA?

Southwest Airlines, American Airlines, and United Airlines fly from Louisville International Airport (SDF) to San Diego International Airport (SAN) every 3 hours. Alternatively, you can take a bus from Louisville, KY to San Diego via Evansville Bus Station, St Louis Bus Station, and Los Angeles Union Station in around 2d 4h.

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