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How to get fromLouisville to Sanibel Islandby plane, bus (Amtrak, Greyhound, Flixbus), car, bus, or bus (Amtrak, Greyhound)

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There are 5 ways to get from Louisville to Sanibel Island by plane, bus (Amtrak, Greyhound, Flixbus), car, bus, or bus (Amtrak, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Louisville International Airport

    best
    1. Fly from Louisville International Airport (SDF) to Ft. Myers (RSW)plane plane SDF - RSW
    4h 28m
    $187–643

  2. Drive 948.7 mi

    cheapest
    1. Drive from Louisville to Sanibel Islandcar car 948.7 mi
    17h 50m
    $174–251

  3. Bus via Atlanta

    1. Take the bus from Louisville, KY to Nashvillebus bus
    2. Take the bus from Nashville Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to University of South Floridabus bus
    4. Take the bus from University of South Florida - 3801 USF Holly Dr to Fort Myers 7-11bus bus
    21h 13m
    $238–391

  4. Bus to Covington, fly

    1. Take the bus from Louisville, KY Bus Station to Cincinnati - Downtownbus bus
    2. Fly from Covington (CVG) to Ft. Myers (RSW)plane plane CVG - RSW
    6h 31m
    $257–785

  5. Bus

    1. Take the bus from Louisville, KY to Nashvillebus bus
    2. Take the bus from Nashville Bus Station to Tallahasseebus bus
    3. Take the bus from Tallahassee to Fort Myersbus bus
    23h 32m
    $245–373

Louisville International Airport (SDF) to Ft. Myers (RSW) flights

Calendar58Weekly Planes
Duration4h 22mAverage Duration
Ticket$113Cheapest Price
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Questions & Answers

Map of how to get from Louisville to Sanibel Island.ExpandLaunch map view
  • Distance: 868.4 mi
  • Duration: 4h 28m

What companies run services between Louisville, KY, USA and Sanibel Island, FL, USA?

Breeze Airways, Southwest Airlines, and two other airlines fly from Louisville International Airport (SDF) to Ft. Myers (RSW) every 4 hours. Alternatively, you can take a bus from Louisville, KY to Sanibel Island via Nashville Bus Station, Atlanta Bus Station, University of South Florida - 3801 USF Holly Dr, and Fort Myers 7-11 in around 21h 13m.

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