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How to get fromLouisville to Sikestonby bus, car, or plane

Find Transport to Sikeston

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There are 4 ways to get from Louisville to Sikeston by bus, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, drive

    best
    1. Take the bus from Louisville Bus Station to Clarksville Park & Ridebus bus
    2. Take the bus from Clarksville Park & Ride to Paducah Bus Stationbus bus
    3. Drive from Paducah Bus Station to Sikestoncar car
    7h 27m
    $54–95

  2. Drive 275.7 mi

    cheapest
    1. Drive from Louisville to Sikestoncar car 275.7 mi
    4h 47m
    $51–73

  3. Fly to Barkley Regional Airport, drive

    1. Fly from Louisville International Airport (SDF) to Barkley Regional Airport (PAH)plane plane SDF - PAH
    2. Drive from Barkley Regional Airport (PAH) to Sikestoncar car
    7h 49m
    $97–468

  4. Fly to Williamson County Regional Airport, bus

    1. Fly from Louisville International Airport (SDF) to Williamson County Regional Airport (MWA)plane plane SDF - MWA
    2. Take the bus from Marathon Gas Station - Marion to Flying J - Matthewsbus bus
    8h 56m
    $165–654

Louisville International Airport (SDF) to Barkley Regional Airport (PAH) flights

Calendar29Weekly Planes
Duration7h 53mAverage Duration
Ticket$86Cheapest Price
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Questions & Answers

Map of how to get from Louisville to Sikeston.ExpandLaunch map view
  • Distance: 335 mi
  • Duration: 7h 27m

What companies run services between Louisville, KY, USA and Sikeston, MO, USA?

There is no direct connection from Louisville to Sikeston. However, you can take the bus to Clarksville Park & Ride, take the bus to Paducah Bus Station, then drive to Sikeston. Alternatively, you can drive from Louisville to Sikeston in around 4h 47m.

Airlines
Bus operators

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