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How to get fromLouisville to Sioux Fallsby plane, bus (Greyhound, Flixbus), bus, train, car, or bus (Greyhound, Amtrak)

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There are 7 ways to get from Louisville to Sioux Falls by plane, bus (Greyhound, Flixbus), bus, train, car, or bus (Greyhound, Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Louisville International Airport

    best
    1. Fly from Louisville International Airport (SDF) to Sioux Falls (FSD)plane plane SDF - FSD
    6h 59m
    $99–485

  2. Bus via Minneapolis

    1. Take the bus from Louisville Bus Station to Chicago Bus Stationbus bus
    2. Take the bus from Chicago Bus Station to Minneapolis Bus Stationbus bus
    3. Take the bus from Minneapolis to Sioux Fallsbus bus
    23h 23m
    $179–321

  3. Bus, train

    1. Take the bus from Louisville Bus Station to Indianapolis Union Stationbus bus
    2. Take the train from Indianapolis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    4. Take the bus from St. Paul to Albert Leabus bus
    5. Take the bus from Albert Lea to Sioux Fallsbus bus
    23h 45m
    $301–581

  4. Drive 846.5 mi

    1. Drive from Louisville to Sioux Fallscar car 846.5 mi
    14h 12m
    $155–224

  5. Bus to Covington, fly

    1. Take the bus from Louisville, KY Bus Station to Cincinnati - Downtownbus bus
    2. Fly from Covington (CVG) to Sioux Falls (FSD)plane plane CVG - FSD
    8h 58m
    $114–597

  6. Bus to Nashville, fly

    1. Take the bus from Louisville Bus Station to Nashville Bus Stationbus bus
    2. Fly from Nashville (BNA) to Sioux Falls (FSD)plane plane BNA - FSD
    7h 59m
    $122–516

  7. Bus

    1. Take the bus from Louisville Bus Station to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis to Omahabus bus
    3. Take the bus from Omaha to Sioux Fallsbus bus
    23h 43m

Louisville International Airport (SDF) to Sioux Falls (FSD) flights

Calendar91Weekly Planes
Duration5h 46mAverage Duration
Ticket$96Cheapest Price
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Questions & Answers

Map of how to get from Louisville to Sioux Falls.ExpandLaunch map view
  • Distance: 695.9 mi
  • Duration: 6h 59m

What companies run services between Louisville, KY, USA and Sioux Falls, SD, USA?

Delta, United Airlines, and American Airlines fly from Louisville International Airport (SDF) to Sioux Falls (FSD) hourly. Alternatively, you can take a bus from Louisville Bus Station to The Bus Stop via Chicago Bus Station, Minneapolis, Sioux Falls, and Maple/Career NE corner in around 23h 23m.

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