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How to get fromLouisville to Sioux Fallsby plane, bus (Amtrak, Greyhound), bus, train, car, or bus (Amtrak, Flixbus)

Find Transport to Sioux Falls

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There are 8 ways to get from Louisville to Sioux Falls by plane, bus (Amtrak, Greyhound), bus, train, car, or bus (Amtrak, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Louisville International Airport

    best
    1. Fly from Louisville International Airport (SDF) to Sioux Falls (FSD)plane plane SDF - FSD
    7h 6m
    $94–505

  2. Bus

    1. Take the bus from Louisville, KY to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis Union Station to Des Moinesbus bus
    3. Take the bus from Des Moines to Omaha, NEbus bus
    4. Take the bus from Omaha to Sioux Fallsbus bus
    22h 53m
    $179–291

  3. Bus, train

    1. Take the bus from Louisville, KY to Indianapolis Union Stationbus bus
    2. Take the train from Indianapolis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    4. Take the bus from Minneapolis to Sioux Fallsbus bus
    24h 28m
    $423–683

  4. Drive  825 mi

    1. Drive from Louisville to Sioux Fallscar car 825 mi
    15h 3m
    $151–218

  5. Drive to Covington, fly

    1. Drive from Louisville to Covington (CVG)car car
    2. Fly from Covington (CVG) to Sioux Falls (FSD)plane plane CVG - FSD
    6h 55m
    $139–727

  6. Bus to Nashville, fly

    1. Take the bus from Louisville, KY to Nashvillebus bus
    2. Fly from Nashville (BNA) to Sioux Falls (FSD)plane plane BNA - FSD
    7h 59m
    $122–530

  7. Bus to Indianapolis, fly

    1. Take the bus from Louisville, KY to Indianapolis Union Stationbus bus
    2. Fly from Indianapolis (IND) to Sioux Falls (FSD)plane plane IND - FSD
    9h 57m
    $120–530

  8. Bus via Milwaukee Airport (MKE)

    1. Take the bus from Louisville, KY to Chicago Union Stationbus bus
    2. Take the bus from Chicago Bus Station to Milwaukee Mitchell Airportbus bus
    3. Take the bus from Milwaukee Mitchell Airport to Minneapolis Bus Stationbus bus
    4. Take the bus from Minneapolis to Sioux Fallsbus bus
    25h 22m
    $185–264

Louisville International Airport (SDF) to Sioux Falls (FSD) flights

Calendar91Weekly Planes
Duration5h 54mAverage Duration
Ticket$92Cheapest Price
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Comparing Your Travel Options

Map of how to get from Louisville to Sioux Falls.ExpandLaunch map view
  • Distance: 695.9 mi
  • Duration: 7h 6m

What companies run services between Louisville, KY, USA and Sioux Falls, SD, USA?

Delta, United Airlines, and American Airlines fly from Louisville International Airport (SDF) to Sioux Falls (FSD) hourly. Alternatively, you can take a bus from Louisville, KY to The Bus Stop via Indianapolis Union Station, Des Moines, Omaha, Sioux Falls, and Maple/Career NE corner in around 22h 53m.

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