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How to get fromLouisville to South Carolinaby plane, taxi, bus (Amtrak, Greyhound, Flixbus), car, or bus (Greyhound)

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There are 7 ways to get from Louisville to South Carolina by plane, taxi, bus (Amtrak, Greyhound, Flixbus), car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Louisville International Airport to Charlotte Douglas International Airport, taxi

    best
    1. Fly from Louisville International Airport (SDF) to Charlotte Douglas International Airport (CLT)plane plane SDF - CLT
    2. Take the taxi from Charlotte-Airport-CLT to Rock Hilltaxi taxi
    3h 36m
    $172–703

  2. Drive 580.9 mi

    cheapest
    1. Drive from Louisville to Charlestoncar car 580.9 mi
    11h 18m
    $106–154

  3. Bus via Nashville

    1. Take the bus from Louisville, KY to Nashvillebus bus
    2. Take the bus from Nashville Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Charleston Bus Stationbus bus
    22h 40m
    $142–260

  4. Drive to Blue Grass Airport, fly to Charlotte Douglas International Airport, taxi

    1. Drive from Louisville to Lexington-Airport-LEXcar car
    2. Fly from Blue Grass Airport (LEX) to Charlotte Douglas International Airport (CLT)plane plane LEX - CLT
    3. Take the taxi from Charlotte-Airport-CLT to Rock Hilltaxi taxi
    3h 28m
    $193–819

  5. Fly Louisville International Airport to Charleston International Airport

    1. Fly from Louisville International Airport (SDF) to Charleston International Airport (CHS)plane plane SDF - CHS
    4h 9m
    $344–405

  6. Fly Louisville International Airport to Columbia

    1. Fly from Louisville International Airport (SDF) to Columbia (CAE)plane plane SDF - CAE
    6h 8m
    $174–1,105

  7. Bus

    1. Take the bus from Louisville, KY to Evansville, INbus bus
    2. Take the bus from Evansville Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Charleston Bus Stationbus bus
    25h 29m
    $172–315

Louisville to South Carolina by bus

Calendar14Weekly Buses
Duration22h 40mAverage Duration
Ticket$142Cheapest Price
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Questions & Answers

Map of how to get from Louisville to South Carolina.ExpandLaunch map view
  • Distance: 369.8 mi
  • Duration: 3h 36m

What companies run services between Louisville, KY, USA and South Carolina, USA?

You can take a bus from Louisville, KY to Broad St / Meeting St via Nashville Bus Station, Atlanta Bus Station, Charleston Bus Station, North Charleston Transit Center, N. Charleston SuperStop, Rivers Ave / Cosgrove Ave, Transit Mall, and Visitors Center on John St in around 22h 40m. Alternatively, Breeze Airways, Southwest Airlines, and two other airlines fly from Louisville International Airport (SDF) to Charleston International Airport (CHS) 5 times a day.

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