Rome2Rio

How to get fromLouisville to Spartanburgby plane, bus (Amtrak, Greyhound, Flixbus), car, bus, or train

Find Transport to Spartanburg

See all options

There are 7 ways to get from Louisville to Spartanburg by plane, bus (Amtrak, Greyhound, Flixbus), car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Louisville International Airport to Greenville–Spartanburg International Airport

    best
    1. Fly from Louisville International Airport (SDF) to Greenville–Spartanburg International Airport (GSP)plane plane SDF - GSP
    4h 55m
    $157–673

  2. Drive 381 mi

    cheapest
    1. Drive from Louisville to Spartanburgcar car 381 mi
    8h 5m
    $70–101

  3. Bus

    1. Take the bus from Louisville, KY to Nashvillebus bus
    2. Take the bus from Nashville Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Greenvillebus bus
    12h 36m
    $160–251

  4. Bus to Covington, fly to Greenville–Spartanburg International Airport

    1. Take the bus from Louisville, KY Bus Station to Cincinnati - Downtownbus bus
    2. Fly from Covington (CVG) to Greenville–Spartanburg International Airport (GSP)plane plane CVG - GSP
    5h 25m
    $187–815

  5. Fly Louisville International Airport to Charlotte Douglas International Airport, train

    1. Fly from Louisville International Airport (SDF) to Charlotte Douglas International Airport (CLT)plane plane SDF - CLT
    2. Take the train from Charlotte Amtrak Station to Spartanburg Stationtrain train
    6h 39m
    $120–664

  6. Bus to Nashville, fly to Greenville–Spartanburg International Airport

    1. Take the bus from Louisville, KY to Nashvillebus bus
    2. Fly from Nashville (BNA) to Greenville–Spartanburg International Airport (GSP)plane plane BNA - GSP
    6h 16m
    $170–668

  7. Bus, train

    1. Take the bus from Louisville, KY Bus Station to Columbus - Downtown - Mound Stbus bus
    2. Take the bus from Columbus - Mound St to Hurricanebus bus
    3. Take the bus from Hurricane to Charlotte Bus Stationbus bus
    4. Take the train from Charlotte Amtrak Station to Spartanburg Stationtrain train
    19h 9m
    $90–250

Louisville to Spartanburg by bus and train

Calendar7Weekly Services
Duration19h 9mAverage Duration
Ticket$90Cheapest Price
See schedules

Questions & Answers

Map of how to get from Louisville to Spartanburg.ExpandLaunch map view
  • Distance: 325.8 mi
  • Duration: 4h 55m

What companies run services between Louisville, KY, USA and Spartanburg, SC, USA?

Southwest Airlines, Delta, and two other airlines fly from Louisville International Airport (SDF) to Greenville–Spartanburg International Airport (GSP) hourly. Alternatively, you can take a bus from Louisville, KY to Spartanburg via Nashville Bus Station, Atlanta Bus Station, and Greenville in around 12h 36m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers