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How to get fromLouisville to Syracuseby plane, bus, train, car, bus (Greyhound, Flixbus), or bus (Flixbus)

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There are 9 ways to get from Louisville to Syracuse by plane, bus, train, car, bus (Greyhound, Flixbus), or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Louisville International Airport to Syracuse Hancock International Airport

    best
    1. Fly from Louisville International Airport (SDF) to Syracuse Hancock International Airport (SYR)plane plane SDF - SYR
    7h 19m
    $163–911

  2. Bus via Akron

    cheapest
    1. Take the bus from Louisville, KY Bus Station to Robert K Pfaff Transit Center - Akronbus bus
    2. Take the bus from Robert K Pfaff Transit Center - Akron to Buffalo, NYbus bus
    3. Take the bus from Buffalo to Syracusebus bus 325
    15h 37m
    $79–192

  3. Bus, train

    1. Take the bus from Louisville, KY Bus Station to Cleveland Ohio Greyhound Stationbus bus Louisville
    2. Take the train from Cleveland Amtrak to Syracuse Regional Transportation Centertrain train Lake Shore Limited
    14h 6m
    $138–303

  4. Drive 676 mi

    1. Drive from Louisville to Syracusecar car 676 mi
    11h 30m
    $124–179

  5. Drive to Blue Grass Airport, fly to Syracuse Hancock International Airport

    1. Drive from Louisville to Lexington-Airport-LEXcar car
    2. Fly from Blue Grass Airport (LEX) to Syracuse Hancock International Airport (SYR)plane plane LEX - SYR
    7h 26m
    $204–1,127

  6. Fly Louisville International Airport to Rochester, train

    1. Fly from Louisville International Airport (SDF) to Rochester (ROC)plane plane SDF - ROC
    2. Take the train from Rochester to Syracuse Regional Transportation Centertrain train
    7h 47m
    $411–795

  7. Fly Louisville International Airport to Ithaca Tompkins Regional Airport, bus

    1. Fly from Louisville International Airport (SDF) to Ithaca Tompkins Regional Airport (ITH)plane plane SDF - ITH
    2. Take the bus from Ithaca to Syracuse Bus Stationbus bus
    8h 54m
    $101–509

  8. Bus to Covington, fly to Syracuse Hancock International Airport

    1. Take the bus from Louisville, KY Bus Station to Cincinnati - Downtownbus bus
    2. Fly from Covington (CVG) to Syracuse Hancock International Airport (SYR)plane plane CVG - SYR
    9h 16m
    $173–953

  9. Bus

    1. Take the bus from Louisville, KY Bus Station to Greyhound Station Cincinnatibus bus
    2. Take the bus from Cincinnati, OH to Buffalo, NYbus bus
    3. Take the bus from Buffalo Niagara International Airport to Syracuse Bus Stationbus bus
    17h 24m
    $85–231

Louisville to Syracuse by bus, foot, and train

Calendar14Weekly Services
Duration14h 6mAverage Duration
Ticket$138Cheapest Price
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Questions & Answers

Map of how to get from Louisville to Syracuse.ExpandLaunch map view
  • Distance: 626.6 mi
  • Duration: 7h 19m

What companies run services between Louisville, KY, USA and Syracuse, NY, USA?

United Airlines, Delta, and American Airlines fly from Louisville International Airport (SDF) to Syracuse Hancock International Airport (SYR) hourly. Alternatively, you can take a bus from Louisville, KY Bus Station to Syracuse via Robert K Pfaff Transit Center - Akron and Buffalo in around 15h 37m.

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