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How to get fromLouisville to Tupeloby bus (Amtrak, Greyhound, Flixbus), car, plane, bus (Greyhound), or bus

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There are 7 ways to get from Louisville to Tupelo by bus (Amtrak, Greyhound, Flixbus), car, plane, bus (Greyhound), or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus via Nashville

    best
    1. Take the bus from Louisville, KY to Nashvillebus bus
    2. Take the bus from Nashville Bus Station to Memphis Bus Stationbus bus
    3. Take the bus from Memphis Bus Station to Tupelobus bus
    10h 9m
    $90–155

  2. Drive 369.1 mi

    cheapest
    1. Drive from Louisville to Tupelocar car 369.1 mi
    7h 19m
    $68–98

  3. Fly Louisville International Airport to Golden Triangle Regional Airport, drive

    1. Fly from Louisville International Airport (SDF) to Golden Triangle Regional Airport (GTR)plane plane SDF - GTR
    2. Drive from Golden Triangle Regional Airport (GTR) to Tupelocar car
    7h 27m
    $93–450

  4. Bus

    1. Take the bus from La Tropicana - Louisville, KY to Tornado Bus Co - West Memphisbus bus Indianapolis
    2. Take the bus from Memphis Bus Station to Tupelobus bus Greyhound US0610
    13h 30m
    $128–266

  5. Bus to Nashville, fly to Tupelo Regional Airport

    1. Take the bus from Louisville, KY to Nashvillebus bus
    2. Fly from Nashville (BNA) to Tupelo Regional Airport (TUP)plane plane BNA - TUP
    5h 52m
    $104–236

  6. Fly Louisville International Airport to Tupelo Regional Airport

    1. Fly from Louisville International Airport (SDF) to Tupelo Regional Airport (TUP)plane plane SDF - TUP
    5h 16m
    $111–501

  7. Fly Louisville International Airport to Memphis, bus

    1. Fly from Louisville International Airport (SDF) to Memphis (MEM)plane plane SDF - MEM
    2. Take the bus from Memphis Bus Station to Tupelobus bus
    8h 30m
    $130–698

Louisville International Airport (SDF) to Golden Triangle Regional Airport (GTR) flights

Calendar17Weekly Planes
Duration4h 57mAverage Duration
Ticket$80Cheapest Price
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Questions & Answers

Map of how to get from Louisville to Tupelo.ExpandLaunch map view
  • Distance: 488.2 mi
  • Duration: 10h 9m

What companies run services between Louisville, KY, USA and Tupelo, MS, USA?

You can take a bus from Louisville, KY to Tupelo via Nashville Bus Station, Memphis Bus Station, and Tupelo in around 10h 9m. Alternatively, Southwest Airlines, Corporate Flight Management Inc, and two other airlines fly from Louisville International Airport (SDF) to Tupelo Regional Airport (TUP) twice daily.

Airlines
Bus operators

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