Rome2Rio

How to get fromLouisville to Tupeloby bus (Greyhound, Amtrak, Flixbus), car, plane, bus (Greyhound), or bus

Find Transport to Tupelo

See all options

There are 7 ways to get from Louisville to Tupelo by bus (Greyhound, Amtrak, Flixbus), car, plane, bus (Greyhound), or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus via Nashville

    best
    1. Take the bus from Louisville Bus Station to Nashville Bus Stationbus bus
    2. Take the bus from Nashville Bus Station to Memphis Bus Stationbus bus
    3. Take the bus from Memphis Bus Station to Tupelobus bus
    10h 4m
    $83–137

  2. Drive  369.1 mi

    cheapest
    1. Drive from Louisville to Tupelocar car 369.1 mi
    7h 19m
    $68–98

  3. Fly Louisville International Airport to Golden Triangle Regional Airport, drive

    1. Fly from Louisville International Airport (SDF) to Golden Triangle Regional Airport (GTR)plane plane SDF - GTR
    2. Drive from Golden Triangle Regional Airport (GTR) to Tupelocar car
    6h 14m
    $98–500

  4. Bus

    1. Take the bus from La Tropicana - Louisville, KY to Tornado Bus Co - West Memphisbus bus Indianapolis
    2. Take the bus from Memphis Bus Station to Tupelobus bus Greyhound US0610
    13h 30m
    $132–171

  5. Bus to Nashville, fly to Tupelo Regional Airport

    1. Take the bus from Louisville Bus Station to Nashville Bus Stationbus bus
    2. Fly from Nashville (BNA) to Tupelo Regional Airport (TUP)plane plane BNA - TUP
    5h 47m
    $98–233

  6. Fly Louisville International Airport to Tupelo Regional Airport

    1. Fly from Louisville International Airport (SDF) to Tupelo Regional Airport (TUP)plane plane SDF - TUP
    7h 36m
    $126–621

  7. Fly Louisville International Airport to Memphis, bus

    1. Fly from Louisville International Airport (SDF) to Memphis (MEM)plane plane SDF - MEM
    2. Take the bus from Memphis Bus Station to Tupelobus bus
    8h 30m
    $149–843

Louisville International Airport (SDF) to Golden Triangle Regional Airport (GTR) flights

Calendar21Weekly Planes
Duration4h 28mAverage Duration
Ticket$85Cheapest Price
See schedules

Questions & Answers

Map of how to get from Louisville to Tupelo.ExpandLaunch map view
  • Distance: 488.4 mi
  • Duration: 10h 4m

What companies run services between Louisville, KY, USA and Tupelo, MS, USA?

You can take a bus from Louisville Bus Station to Tupelo via Nashville Bus Station, Memphis Bus Station, and Tupelo in around 10h 4m. Alternatively, Southwest Airlines, Corporate Flight Management Inc, and two other airlines fly from Louisville International Airport (SDF) to Tupelo Regional Airport (TUP) twice daily.

Airlines
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers