There are 5 ways to get from Louisville to Winston-Salem by plane, bus (Greyhound), car, or bus
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Piedmont Triad International Airport
best- Fly from Louisville International Airport (SDF) to Piedmont Triad International Airport (GSO)plane SDF - GSO
6h 10m$131–676Drive 420.1 mi
cheapest- Drive from Louisville to Winston-Salemcar 420.1 mi
8h 8m$77–111Bus
- Take the bus from Louisville, KY Bus Station to Columbus - Downtown - Mound Stbus Louisville
- Take the bus from Columbus to Winston Salem(Trans Center)bus Greyhound US0140
14h 45m$99–194Fly to Charlotte Douglas International Airport, bus
- Fly from Louisville International Airport (SDF) to Charlotte Douglas International Airport (CLT)plane SDF - CLT
- Take the bus from Charlotte Bus Station to Winston Salem(Trans Center)bus
6h 15m$103–649Fly to Raleigh-Durham International Airport, bus
- Fly from Louisville International Airport (SDF) to Raleigh-Durham International Airport (RDU)plane SDF - RDU
- Take the bus from Durham to Winston Salem(Trans Center)bus
7h 2m$100–493
Louisville to Winston-Salem by bus
Questions & Answers
The cheapest way to get from Louisville to Winston-Salem is to drive which costs $75 - $120 and takes 8h 8m.
The fastest way to get from Louisville to Winston-Salem is to fly which takes 6h 10m and costs $130 - $700.
No, there is no direct bus from Louisville station to Winston-Salem. However, there are services departing from Louisville, KY Bus Station and arriving at Winston Salem(Trans Center) via Columbus. The journey, including transfers, takes approximately 14h 45m.
The distance between Louisville and Winston-Salem is 382 miles. The road distance is 422.6 miles.
The best way to get from Louisville to Winston-Salem without a car is to bus which takes 14h 45m and costs $95 - $200.
It takes approximately 6h 10m to get from Louisville to Winston-Salem, including transfers.
Louisville to Winston-Salem bus services, operated by Barons Bus, depart from Louisville, KY Bus Station.
The best way to get from Louisville to Winston-Salem is to fly which takes 6h 10m and costs $130 - $700. Alternatively, you can bus, which costs $95 - $200 and takes 14h 45m.
Louisville to Winston-Salem bus services, operated by Barons Bus, arrive at Columbus - Downtown - Mound St station.
Yes, the driving distance between Louisville to Winston-Salem is 423 miles. It takes approximately 8h 8m to drive from Louisville to Winston-Salem.
What companies run services between Louisville, KY, USA and Winston-Salem, NC, USA?
Delta, American Airlines, and United Airlines fly from Louisville International Airport (SDF) to Piedmont Triad International Airport (GSO) hourly. Alternatively, you can take a bus from Louisville, KY Bus Station to Winston Salem(Trans Center) via Columbus in around 14h 45m.
- Website
- aa.com
Flights from Louisville International Airport to Piedmont Triad International Airport via Charlotte Douglas International Airport
- Ave. Duration
- 4h 7m
- When
- Every day
- Estimated price
- $110–650
Flights from Louisville International Airport to Piedmont Triad International Airport via Reagan Washington
- Ave. Duration
- 4h 56m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $150–800
Flights from Louisville International Airport to Piedmont Triad International Airport via Chicago O'Hare
- Ave. Duration
- 7h 14m
- When
- Every day
- Estimated price
- $170–850
Flights from Louisville International Airport to Piedmont Triad International Airport via Philadelphia
- Ave. Duration
- 6h 32m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $180–900
Flights from Louisville International Airport to Charlotte Douglas International Airport
- Ave. Duration
- 1h 38m
- When
- Every day
- Estimated price
- $90–600
Flights from Louisville International Airport to Raleigh-Durham International Airport via Charlotte Douglas International Airport
- Ave. Duration
- 3h 45m
- When
- Every day
- Estimated price
- $80–460
- Website
- delta.com
Flights from Louisville International Airport to Piedmont Triad International Airport via Atlanta
- Ave. Duration
- 4h 1m
- When
- Every day
- Estimated price
- $140–750
Flights from Louisville International Airport to Piedmont Triad International Airport via Detroit
- Ave. Duration
- 5h 42m
- When
- Every day
- Estimated price
- $160–800
- Website
- united.com
Flights from Louisville International Airport to Piedmont Triad International Airport via Washington Dulles
- Ave. Duration
- 4h 23m
- When
- Every day
- Estimated price
- $150–800
Flights from Louisville International Airport to Piedmont Triad International Airport via Chicago O'Hare
- Ave. Duration
- 6h 23m
- When
- Every day
- Estimated price
- $170–850
- Website
- southwest.com
Flights from Louisville International Airport to Charlotte Douglas International Airport via Nashville
- Ave. Duration
- 3h 20m
- When
- Monday, Thursday, and Friday
- Estimated price
- $110–650
Flights from Louisville International Airport to Raleigh-Durham International Airport via Baltimore
- Ave. Duration
- 3h 50m
- When
- Sunday
- Estimated price
- $100–550
- Website
- flybreeze.com
Flights from Louisville International Airport to Raleigh-Durham International Airport
- Ave. Duration
- 1h 29m
- When
- Wednesday and Saturday
- Estimated price
- $180–1,200
- Phone
- +1 888-378-3823
- [email protected]
- Website
- baronsbus.com
Bus from Louisville, KY Bus Station to Columbus - Downtown - Mound St
- Ave. Duration
- 4h 25m
- Frequency
- Twice daily
- Estimated price
- $21–60
- Website
- https://baronsbus.com
Bus from Charlotte Bus Station to Winston Salem(Trans Center)
- Ave. Duration
- 1h 15m
- Frequency
- Once daily
- Estimated price
- $7–40
- Website
- https://baronsbus.com
- Website
- example.com
Bus from Louisville, KY Bus Station to Columbus - Downtown - Mound St
- Ave. Duration
- 4h 15m
- Frequency
- Once daily
- Schedules at
- example.com
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- greyhound.com
Bus from Louisville, KY Bus Station to Columbus - Downtown - Mound St
- Ave. Duration
- 5h 25m
- Frequency
- Once daily
- Estimated price
- $30–65
- Website
- https://www.greyhound.com/
Bus from Columbus to Winston Salem(Trans Center)
- Ave. Duration
- 9h 20m
- Frequency
- Once daily
- Estimated price
- $65–130
- Website
- https://www.greyhound.com/
Bus from Charlotte Bus Station to Winston Salem(Trans Center)
- Ave. Duration
- 1h 25m
- Frequency
- Twice daily
- Estimated price
- $12–23
- Website
- https://www.greyhound.com/
Bus from Durham to Winston Salem(Trans Center)
- Ave. Duration
- 1h 35m
- Frequency
- 3 times a day
- Estimated price
- $12–24
- Website
- https://www.greyhound.com/
- Website
- greyhound.com
Bus from Louisville, KY Bus Station to Columbus - Downtown - Mound St
- Ave. Duration
- 5h 35m
- Frequency
- Once daily
- Schedules at
- greyhound.com
Bus from Columbus to Winston Salem(Trans Center)
- Ave. Duration
- 9h 25m
- Frequency
- Once daily
- Schedules at
- greyhound.com
Bus from Charlotte Bus Station to Winston Salem(Trans Center)
- Ave. Duration
- 1h 25m
- Frequency
- Twice daily
- Schedules at
- greyhound.com
Bus from Durham to Winston Salem(Trans Center)
- Ave. Duration
- 1h 35m
- Frequency
- 3 times a day
- Schedules at
- greyhound.com
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