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How to get fromLouisville to Wythevilleby bus (Amtrak, Greyhound), bus, train, car, plane, or shuttle

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There are 8 ways to get from Louisville to Wytheville by bus (Amtrak, Greyhound), bus, train, car, plane, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Louisville, KY to Nashvillebus bus Chicago
    2. Take the bus from Nashville Bus Station to Max Meadowsbus bus Greyhound US0600
    11h 9m
    $123–201

  2. Drive 337.5 mi

    cheapest
    1. Drive from Louisville to Wythevillecar car 337.5 mi
    6h 36m
    $62–89

  3. Bus, train

    1. Take the bus from Louisville, KY to Indianapolis Union Stationbus bus
    2. Take the train from Indianapolis to Ashland Amtrak Stationtrain train
    3. Take the bus from Ashland Bus Station to Charleston Bus Stationbus bus
    4. Take the bus from Charleston, WV to Wythevillebus bus
    15h 54m
    $150–342

  4. Fly Louisville International Airport to Charlotte Douglas International Airport, bus

    1. Fly from Louisville International Airport (SDF) to Charlotte Douglas International Airport (CLT)plane plane SDF - CLT
    2. Take the bus from Charlotte Bus Station to Max Meadowsbus bus
    7h 5m
    $150–694

  5. Bus via Columbus

    1. Take the bus from Louisville, KY Bus Station to Columbus - Downtown - Mound Stbus bus Louisville
    2. Take the bus from Columbus - Mound St to Wythevillebus bus Columbus
    12h 59m
    $74–162

  6. Drive to Blue Grass Airport, fly to Charlotte Douglas International Airport, bus

    1. Drive from Louisville to Lexington-Airport-LEXcar car
    2. Fly from Blue Grass Airport (LEX) to Charlotte Douglas International Airport (CLT)plane plane LEX - CLT
    3. Take the bus from Charlotte Bus Station to Max Meadowsbus bus
    6h 57m
    $171–810

  7. Fly Louisville International Airport to Roanoke Regional Airport-Woodrum Field, bus

    1. Fly from Louisville International Airport (SDF) to Roanoke Regional Airport-Woodrum Field (ROA)plane plane SDF - ROA
    2. Take the bus from Airport to Exit 118 - Park and Ridebus bus
    3. Take the bus from Christiansburg to Wytheville Rural King Parking Lotbus bus
    9h 6m
    $94–450

  8. Fly Louisville International Airport to Tri-Cities Regional Tn/Va Airport, shuttle, bus

    1. Fly from Louisville International Airport (SDF) to Tri-Cities Regional Tn/Va Airport (TRI)plane plane SDF - TRI
    2. Take a shuttle bus from Black Bear Resort to Low Gapshuttle bus
    3. Take the bus from Bristol Exit 5 Park & Ride Lot to Wytheville Rural King Parking Lotbus bus
    10h 39m
    $312–792

Louisville International Airport (SDF) to Charlotte Douglas International Airport (CLT) flights

Calendar38Weekly Planes
Duration1h 51mAverage Duration
Ticket$92Cheapest Price
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Questions & Answers

Map of how to get from Louisville to Wytheville.ExpandLaunch map view
  • Distance: 562.5 mi
  • Duration: 11h 9m

What companies run services between Louisville, KY, USA and Wytheville, VA, USA?

You can take a bus from Louisville, KY to Wytheville via Nashville Bus Station and Max Meadows in around 11h 9m.

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Train operators
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