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How to get fromLowell to Indianapolisby plane, bus (Greyhound, Flixbus), train, bus, car, bus (Greyhound), or train (Amtrak)

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There are 8 ways to get from Lowell to Indianapolis by plane, bus (Greyhound, Flixbus), train, bus, car, bus (Greyhound), or train (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Boston Logan Airport

    best
    1. Fly from Boston Logan Airport (BOS) to Indianapolis (IND)plane plane BOS - IND
    6h 3m
    $193–969

  2. Train, train to Theodore Francis Green State Airport, fly

    cheapest
    1. Take the train from Lowell to North Stationtrain train
    2. Take the train from Ruggles to TF Green Airporttrain train
    3. Fly from Theodore Francis Green State Airport (PVD) to Indianapolis (IND)plane plane PVD - IND
    9h 40m
    $129–680

  3. Bus via Boston

    1. Take the bus from Robert B Kennedy Bus Transfer Center to Bostonbus bus
    2. Take the bus from Boston to New York Midtownbus bus
    3. Take the bus from New York Midtown to Indianapolisbus bus
    23h 20m
    $144–237

  4. Train, bus

    1. Take the train from Lowell to North Stationtrain train
    2. Take the train from Boston to Toledotrain train
    3. Take the bus from Toledo to Indianapolis, INbus bus
    24h 17m
    $219–538

  5. Drive  910.9 mi

    1. Drive from Lowell to Indianapoliscar car 910.9 mi
    16h 29m
    $167–241

  6. Train, bus to Manchester Airport, fly

    1. Take the train from Lowell to North Stationtrain train
    2. Take the bus from Boston to Boston Manchester Airportbus bus
    3. Fly from Manchester Airport (MHT) to Indianapolis (IND)plane plane MHT - IND
    9h 43m
    $198–978

  7. Bus (Greyhound)

    1. Take the bus from Robert B Kennedy Bus Transfer Center to Port Authority Bus Terminalbus bus Greyhound US0256S
    2. Take the bus from Port Authority Bus Terminal to Indianapolis Union Stationbus bus Greyhound US0421
    26h 4m
    $161–264

  8. Train

    1. Take the train from Lowell to North Stationtrain train
    2. Take the train from Boston to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the train from Ny Moynihan Train Hall At Penn Station to Indianapolistrain train
    29h 51m
    $288–1,313

Lowell to Indianapolis by bus

Calendar5Weekly Buses
Duration23h 20mAverage Duration
Ticket$144Cheapest Price
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Comparing Your Travel Options

Map of how to get from Lowell to Indianapolis.ExpandLaunch map view
  • Distance: 858.7 mi
  • Duration: 6h 3m

What companies run services between Lowell, MA, USA and Indianapolis, IN, USA?

American Airlines, Delta, and two other airlines fly from Boston Logan Airport (BOS) to Indianapolis (IND) hourly. Alternatively, you can take a bus from Robert B Kennedy Bus Transfer Center to Indianapolis via Boston and New York Midtown in around 23h 20m.

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