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How to get fromLowell to Knoxvilleby plane, train, bus, car, bus (Greyhound, Flixbus), or bus (Greyhound)

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There are 7 ways to get from Lowell to Knoxville by plane, train, bus, car, bus (Greyhound, Flixbus), or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Boston Logan Airport to Mcghee Tyson Airport

    best
    1. Fly from Boston Logan Airport (BOS) to Mcghee Tyson Airport (TYS)plane plane BOS - TYS
    5h
    $216–837

  2. Fly Boston Logan Airport to Asheville Regional Airport, drive

    cheapest
    1. Fly from Boston Logan Airport (BOS) to Asheville Regional Airport (AVL)plane plane BOS - AVL
    2. Drive from Asheville-Airport-AVL to Knoxvillecar car
    6h 48m
    $113–452

  3. Train, bus

    1. Take the train from Lowell to North Stationtrain train
    2. Take the train from Boston to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    19h 13m
    $196–926

  4. Drive 911.8 mi

    1. Drive from Lowell to Knoxvillecar car 911.8 mi
    16h 1m
    $167–241

  5. Train, bus to Manchester Airport, fly to Mcghee Tyson Airport

    1. Take the train from Lowell to North Stationtrain train
    2. Take the bus from Boston to Boston Manchester Airportbus bus
    3. Fly from Manchester Airport (MHT) to Mcghee Tyson Airport (TYS)plane plane MHT - TYS
    8h 38m
    $256–968

  6. Bus via Boston

    1. Take the bus from Robert B Kennedy Bus Transfer Center to Bostonbus bus
    2. Take the bus from Boston to NYC Downtownbus bus
    3. Take the bus from New York to Knoxvillebus bus Nyc
    19h 50m
    $254–356

  7. Bus

    1. Take the bus from Robert B Kennedy Bus Transfer Center to Port Authority Bus Terminalbus bus Greyhound US0256S
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    25h 26m
    $168–209

Boston Logan Airport (BOS) to Mcghee Tyson Airport (TYS) flights

Calendar79Weekly Planes
Duration4h 31mAverage Duration
Ticket$156Cheapest Price
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Questions & Answers

Map of how to get from Lowell to Knoxville.ExpandLaunch map view
  • Distance: 869.7 mi
  • Duration: 5h

What companies run services between Lowell, MA, USA and Knoxville, TN, USA?

Allegiant Air, Southwest Airlines, and three other airlines fly from Boston Logan Airport (BOS) to Mcghee Tyson Airport (TYS) every 2 hours. Alternatively, you can take a bus from Robert B Kennedy Bus Transfer Center to Knoxville via Boston, NYC Downtown, New York, and Knoxville in around 19h 50m.

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