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How to get fromLowell to Syracuseby bus (Greyhound, Flixbus), train (Amtrak), car, train, plane, or bus

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There are 7 ways to get from Lowell to Syracuse by bus (Greyhound, Flixbus), train (Amtrak), car, train, plane, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Robert B Kennedy Bus Transfer Center to Bostonbus bus Greyhound US0256S
    2. Take the bus from Boston to Syracuse Bus Stationbus bus Greyhound US0171 / ...
    8h 10m
    $49–103

  2. Train

    1. Take the train from Lowell to North Stationtrain train Lowell Line
    2. Take the train from Boston to Syracuse Regional Transportation Centertrain train Lake Shore Limited
    10h 50m
    $118–243

  3. Drive 290.8 mi

    1. Drive from Lowell to Syracusecar car 290.8 mi
    6h 15m
    $54–77

  4. Train, fly to Syracuse Hancock International Airport

    1. Take the train from Lowell to Anderson/Woburntrain train
    2. Fly from Boston Logan Airport (BOS) to Syracuse Hancock International Airport (SYR)plane plane BOS - SYR
    5h 13m
    $97–575

  5. Train, bus

    1. Take the train from Lowell to North Stationtrain train
    2. Take the bus from Boston to Albanybus bus
    3. Take the bus from Albany to Syracusebus bus
    9h 46m
    $59–103

  6. Fly to Rochester, train

    1. Fly from Boston Logan Airport (BOS) to Rochester (ROC)plane plane BOS - ROC
    2. Take the train from Rochester to Syracuse Regional Transportation Centertrain train
    6h 11m
    $135–759

  7. Fly to Buffalo Niagara International Airport, bus

    1. Fly from Boston Logan Airport (BOS) to Buffalo Niagara International Airport (BUF)plane plane BOS - BUF
    2. Take the bus from Buffalo Niagara International Airport to Syracuse Bus Stationbus bus
    7h 17m
    $118–607

Lowell to Syracuse by bus

Calendar10Weekly Buses
Duration8h 10mAverage Duration
Ticket$49Cheapest Price
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Questions & Answers

Map of how to get from Lowell to Syracuse.ExpandLaunch map view
  • Distance: 345 mi
  • Duration: 8h 10m

What companies run services between Lowell, MA, USA and Syracuse, NY, USA?

You can take a bus from Robert B Kennedy Bus Transfer Center to Syracuse Bus Station via Boston in around 8h 10m. Alternatively, you can take a train from Lowell to Syracuse Regional Transportation Center via North Station, North Station, Back Bay, and Boston in around 10h 50m.

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