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How to get fromLuxembourg to Iserniaby plane, train, train (Eurostar, Trenitalia), bus, or car

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There are 7 ways to get from Luxembourg to Isernia by plane, train, train (Eurostar, Trenitalia), bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Luxembourg to Naples Airport, train

    best
    1. Fly from Luxembourg (LUX) to Naples Airport (NAP)plane plane LUX - NAP
    2. Take the train from Caserta to Iserniatrain train
    7h 58m
    €77–262

  2. Train

    1. Take the train from Luxembourg to Bruxelles-Miditrain train Ic / ...
    2. Take the train from Brussel-Zuid / Bruxelles-Midi to Chambery Challes Les Eauxtrain train
    3. Take the train from Chambery Challes Les Eaux to Milano Centraletrain train Fr
    4. Take the train from Milano Centrale to Roma Terminitrain train
    5. Take the train from Roma Termini to Iserniatrain train Re
    19h 36m
    €410–737

  3. Bus

    1. Take the bus from Luxembourg Park&Drive to Casello - A1 Ingresso Caianellobus bus
    2. Take the bus from Casello - A1 Ingresso Caianello to Iserniabus bus 6
    19h 42m
    €165–223

  4. Drive  1,379.9 km

    1. Drive from Luxembourg to Iserniacar car 1,379.9 km
    13h 45m
    €218–315

  5. Fly Luxembourg to Fiumicino International Airport, train

    1. Fly from Luxembourg (LUX) to Fiumicino International Airport (FCO)plane plane LUX - FCO
    2. Take the train from Roma Termini to Iserniatrain train
    7h 52m
    €91–287

  6. Bus to Brussels South Charleroi Airport, fly to Abruzzo Airport, bus

    1. Take the bus from Luxembourg P+R Bouillon to Charleroi Airportbus bus
    2. Fly from Brussels South Charleroi Airport (CRL) to Abruzzo Airport (PSR)plane plane CRL - PSR
    3. Take the bus from Pescara to Iserniabus bus
    11h 11m
    €88–365

  7. Bus via Karlsruhe

    1. Take the bus from Luxembourg, P+R Bouillon to Karlsruhe central train stationbus bus
    2. Take the bus from Karlsruhe central train station to Pescarabus bus
    3. Take the bus from Pescara to Iserniabus bus 433
    25h 39m
    €115–205

Luxembourg to Isernia by train

Calendar5Weekly Trains
Duration19h 36mAverage Duration
Ticket€410Cheapest Price
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Questions & Answers

Map of how to get from Luxembourg to Isernia.ExpandLaunch map view
  • Distance: 1,282.9 km
  • Duration: 7h 58m

What companies run services between Luxembourg and Isernia, Italy?

You can take a train from Luxembourg to Isernia via Brussel-Zuid / Bruxelles-Midi, Chambery Challes Les Eaux, Milano Centrale, and Roma Termini in around 19h 36m. Alternatively, you can take a bus from Luxembourg Park&Drive to Isernia via Casello - A1 Ingresso Caianello in around 19h 42m.

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