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How to get fromLuxembourg to Iserniaby plane, train, train (Eurostar, Trenitalia), bus, or car

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There are 9 ways to get from Luxembourg to Isernia by plane, train, train (Eurostar, Trenitalia), bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Luxembourg to Fiumicino International Airport, train

    best
    1. Fly from Luxembourg (LUX) to Fiumicino International Airport (FCO)plane plane LUX - FCO
    2. Take the train from Roma Termini to Iserniatrain train
    7h 57m
    €90–311

  2. Bus to Brussels South Charleroi Airport, fly to Abruzzo Airport, bus

    cheapest
    1. Take the bus from Luxembourg P+R Bouillon to Charleroi Airportbus bus
    2. Fly from Brussels South Charleroi Airport (CRL) to Abruzzo Airport (PSR)plane plane CRL - PSR
    3. Take the bus from Pescara Airport to San Salvo Marinabus bus
    4. Take the bus from San Salvo Marina to Iserniabus bus
    10h 45m
    €77–302

  3. Train

    1. Take the train from Luxembourg to Bruxelles-Miditrain train Ic / ...
    2. Take the train from Brussel-Zuid / Bruxelles-Midi to Chambery Challes Les Eauxtrain train
    3. Take the train from Chambery Challes Les Eaux to Milano Centraletrain train Fr
    4. Take the train from Milano Centrale to Roma Terminitrain train
    5. Take the train from Roma Termini to Iserniatrain train Re
    19h 39m
    €490–815

  4. Bus

    1. Take the bus from Luxembourg Park&Drive to Casello - A1 Ingresso Caianellobus bus
    2. Take the bus from Casello - A1 Ingresso Caianello to Iserniabus bus 6
    19h 42m
    €165–223

  5. Drive  1,382.3 km

    1. Drive from Luxembourg to Iserniacar car 1,382.3 km
    13h 42m
    €251–362

  6. Fly Luxembourg to Naples Airport, train

    1. Fly from Luxembourg (LUX) to Naples Airport (NAP)plane plane LUX - NAP
    2. Take the train from Caserta to Iserniatrain train
    7h 55m
    €82–259

  7. Fly Luxembourg to Salerno Costa D'Amalfi Airport, train

    1. Fly from Luxembourg (LUX) to Salerno Costa D'Amalfi Airport (QSR)plane plane LUX - QSR
    2. Take the train from Salerno to Casertatrain train
    3. Take the train from Caserta to Iserniatrain train
    12h 45m
    €82–345

  8. Bus to Brussels South Charleroi Airport, fly to Roma Ciampino Airport, train

    1. Take the bus from Luxembourg P+R Bouillon to Charleroi Airportbus bus
    2. Fly from Brussels South Charleroi Airport (CRL) to Roma Ciampino Airport (CIA)plane plane CRL - CIA
    3. Take the train from Roma Termini to Iserniatrain train
    10h 36m
    €139–461

  9. Bus via Karlsruhe

    1. Take the bus from Luxembourg, P+R Bouillon to Karlsruhe central train stationbus bus
    2. Take the bus from Karlsruhe central train station to Pescarabus bus
    3. Take the bus from Pescara to Iserniabus bus 433 / ...
    25h 39m
    €134–220

Luxembourg to Isernia by bus

Calendar7Weekly Buses
Duration25h 39mAverage Duration
Ticket€134Cheapest Price
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Comparing Your Travel Options

Map of how to get from Luxembourg to Isernia.ExpandLaunch map view
  • Distance: 1,214 km
  • Duration: 7h 57m

What companies run services between Luxembourg and Isernia, Italy?

You can take a train from Luxembourg to Isernia via Brussel-Zuid / Bruxelles-Midi, Chambery Challes Les Eaux, Milano Centrale, and Roma Termini in around 19h 39m. Alternatively, you can take a bus from Luxembourg Park&Drive to Isernia via Casello - A1 Ingresso Caianello in around 19h 42m.

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