There are 9 ways to get from Lyon to Siena by train, bus, car, plane, or train (Trenitalia)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train, bus
best- Take the train from Lyon Part Dieu to Torino Porta Susatrain Fr
- Take the train from Torino Porta Susa to Firenze S.M.N.train Fr
- Take the bus from Firenze Autostazione to Siena-Via Tozzibus 131
9h 32m€92–166Bus via Florence
cheapest- Take the bus from Lyon Lyon Perrache Bus Station to Florence Villa Constanza Bus Stationbus Itabus
- Take the bus from Firenze Autostazione to Siena-Via Tozzibus 131R / ...
14h 7m€48–79Bus
- Take the bus from Lyon to Sienabus 516 / ...
11h 20m€65–100Drive 728.1 km
- Drive from Lyon to Sienacar 728.1 km
8h 1m€118–171Fly Lyon–Saint Exupéry Airport to Florence Peretola Airport, train
- Fly from Lyon–Saint Exupéry Airport (LYS) to Florence Peretola Airport (FLR)plane LYS - FLR
- Take the train from Firenze S.M.N. to Sienatrain
6h 39m€74–284Train
- Take the train from Lyon Part Dieu to Milano Centraletrain Fr
- Take the train from Milano Centrale to Firenze S.M.N.train Fr
- Take the train from Firenze S.M.N. to Sienatrain Re
9h 41m€94–164Train to Geneva International Airport, fly to Florence Peretola Airport, train
- Take the train from Lyon Part Dieu to Genevetrain
- Fly from Geneva International Airport (GVA) to Florence Peretola Airport (FLR)plane GVA - FLR
- Take the train from Firenze S.M.N. to Sienatrain
10h 19m€134–330Fly Lyon–Saint Exupéry Airport to Fiumicino International Airport, train
- Fly from Lyon–Saint Exupéry Airport (LYS) to Fiumicino International Airport (FCO)plane LYS - FCO
- Take the train from Roma Termini to Firenze S.M.N.train
- Take the train from Firenze S.M.N. to Sienatrain
9h 10m€108–323Fly Lyon–Saint Exupéry Airport to Venice Marco Polo Airport, train
- Fly from Lyon–Saint Exupéry Airport (LYS) to Venice Marco Polo Airport (VCE)plane LYS - VCE
- Take the train from Venezia Mestre to Firenze S.M.N.train
- Take the train from Firenze S.M.N. to Sienatrain
9h 32m€87–314
Lyon to Siena by train and bus
Comparing Your Travel Options
The cheapest way to get from Lyon to Siena is to bus via Florence which costs €45 - €80 and takes 14h 7m.
The fastest way to get from Lyon to Siena is to fly and train which takes 6h 39m and costs €70 - €290.
Yes, there is a direct bus departing from Lyon and arriving at Siena. Services depart five times a week, and operate Monday, Tuesday, Thursday, Friday, Saturday and Sunday. The journey takes approximately 11h 20m.
No, there is no direct train from Lyon to Siena. However, there are services departing from Lyon Part Dieu and arriving at Siena via Milano Centrale and Firenze S.M.N.. The journey, including transfers, takes approximately 9h 41m.
The distance between Lyon and Siena is 818 km. The road distance is 728.1 km.
The best way to get from Lyon to Siena without a car is to train and bus which takes 9h 32m and costs €90 - €170.
It takes approximately 9h 32m to get from Lyon to Siena, including transfers.
Lyon to Siena bus services, operated by FlixBus, depart from Lyon station.
Lyon to Siena train services, operated by Trenitalia, depart from Lyon Part Dieu station.
The best way to get from Lyon to Siena is to bus which takes 11h 20m and costs €65 - €100. Alternatively, you can train, which costs €90 - €170 and takes 9h 41m.
What companies run services between Lyon, France and Siena, Italy?
FlixBus operates a bus from Lyon to Siena 5 times a week. Tickets cost €65–100 and the journey takes 11h 20m. Alternatively, you can take a train from Lyon Part Dieu to Siena via Milano Centrale and Firenze S.M.N. in around 9h 41m.
- Website
- lufthansa.com
Flights from Lyon–Saint Exupéry Airport to Florence Peretola Airport via Munich
- Ave. Duration
- 3h 25m
- When
- Monday, Wednesday, and Friday
- Estimated price
- €90–280
Flights from Geneva International Airport to Florence Peretola Airport via Munich
- Ave. Duration
- 5h 7m
- When
- Thursday, Saturday, Sunday, and Tuesday
- Estimated price
- €180–650
Flights from Geneva International Airport to Florence Peretola Airport via Frankfurt
- Ave. Duration
- 4h 13m
- When
- Every day
- Estimated price
- €110–650
Flights from Lyon–Saint Exupéry Airport to Venice Marco Polo Airport via Munich
- Ave. Duration
- 3h 10m
- When
- Monday, Wednesday, and Friday
- Estimated price
- €70–230
- Website
- easyjet.com
Flights from Lyon–Saint Exupéry Airport to Fiumicino International Airport
- Ave. Duration
- 1h 35m
- When
- Every day
- Estimated price
- €35–200
Flights from Lyon–Saint Exupéry Airport to Venice Marco Polo Airport
- Ave. Duration
- 1h 15m
- When
- Monday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- €40–230
- Website
- swiss.com
Flights from Geneva International Airport to Florence Peretola Airport via Zurich
- Ave. Duration
- 3h 17m
- When
- Every day
- Estimated price
- €85–240
Flights from Geneva International Airport to Florence Peretola Airport via Fiumicino International Airport
- Ave. Duration
- 5h 12m
- When
- Every day
- Estimated price
- €100–260
- Website
- volotea.com
Flights from Lyon–Saint Exupéry Airport to Florence Peretola Airport
- Ave. Duration
- 1h 20m
- When
- Friday and Sunday
- Estimated price
- €26–200
Flights from Geneva International Airport to Florence Peretola Airport via Fiumicino International Airport
- Ave. Duration
- 6h 40m
- When
- Every day
- Estimated price
- €100–260
Flights from Lyon–Saint Exupéry Airport to Venice Marco Polo Airport
- Ave. Duration
- 1h 20m
- When
- Thursday, Saturday, and Sunday
- Estimated price
- €21–130
- Website
- ita-airways.com
Flights from Geneva International Airport to Florence Peretola Airport via Zurich
- Ave. Duration
- 3h 20m
- When
- Every day
- Estimated price
- €85–240
Flights from Geneva International Airport to Florence Peretola Airport via Fiumicino International Airport
- Ave. Duration
- 5h 12m
- When
- Every day
- Estimated price
- €100–260
- Website
- airdolomiti.it
Flights from Geneva International Airport to Florence Peretola Airport via Munich
- Ave. Duration
- 6h 55m
- When
- Tuesday and Sunday
- Estimated price
- €180–650
- Phone
- +39.06.5210550
- Website
- Trenitalia
Train from Lyon Part Dieu to Torino Porta Susa
- Ave. Duration
- 3h 57m
- Frequency
- Twice daily
- Estimated price
- €35–50
- Website
- Trenitalia
Train from Firenze S.M.N. to Siena
- Ave. Duration
- 1h 30m
- Frequency
- Hourly
- Estimated price
- €11–16
- Website
- Trenitalia
Train from Lyon Part Dieu to Milano Centrale
- Ave. Duration
- 4h 44m
- Frequency
- Twice daily
- Estimated price
- €50–75
- Website
- Trenitalia
Train from Firenze S.M.N. to Siena
- Ave. Duration
- 1h 30m
- Frequency
- Hourly
- Estimated price
- €11–16
- Website
- Trenitalia
Train from Firenze S.M.N. to Siena
- Ave. Duration
- 1h 30m
- Frequency
- Hourly
- Estimated price
- €11–16
- Website
- Trenitalia
Train from Roma Termini to Firenze S.M.N.
- Ave. Duration
- 3h 40m
- Frequency
- 5 times a day
- Estimated price
- €30–45
- Website
- Trenitalia
Train from Firenze S.M.N. to Siena
- Ave. Duration
- 1h 30m
- Frequency
- Hourly
- Estimated price
- €11–16
- Website
- Trenitalia
Train from Firenze S.M.N. to Siena
- Ave. Duration
- 1h 30m
- Frequency
- Hourly
- Estimated price
- €11–16
- Website
- Trenitalia
- Phone
- +39 06 5210550
- Website
- Trenitalia Frecce
Train from Torino Porta Susa to Firenze S.M.N.
- Ave. Duration
- 3h
- Frequency
- Every 2 hours
- Estimated price
- €60–110
- Website
- Trenitalia Frecce
Train from Milano Centrale to Firenze S.M.N.
- Ave. Duration
- 1h 54m
- Frequency
- Every 2 hours
- Estimated price
- €40–75
- Website
- Trenitalia Frecce
Train from Roma Termini to Firenze S.M.N.
- Ave. Duration
- 1h 42m
- Frequency
- Every 30 minutes
- Estimated price
- €35–65
- Website
- Trenitalia Frecce
Train from Venezia Mestre to Firenze S.M.N.
- Ave. Duration
- 2h 1m
- Frequency
- Hourly
- Estimated price
- €30–60
- Website
- Trenitalia Frecce
- Phone
- +39 06 8937 1892
- Website
- Italo Treno
Train from Torino Porta Susa to Firenze S.M.N.
- Ave. Duration
- 3h 23m
- Frequency
- Once daily
- Estimated price
- €50–90
- Website
- Italo Treno
Train from Milano Centrale to Firenze S.M.N.
- Ave. Duration
- 2h 11m
- Frequency
- 4 times a day
- Estimated price
- €35–60
- Website
- Italo Treno
Train from Roma Termini to Firenze S.M.N.
- Ave. Duration
- 1h 51m
- Frequency
- 4 times a day
- Estimated price
- €30–55
- Website
- Italo Treno
Train from Venezia Mestre to Firenze S.M.N.
- Ave. Duration
- 2h 11m
- Frequency
- Once daily
- Estimated price
- €29–50
- Website
- Italo Treno
- Phone
- +39 06 68475475
- Website
- Trenitalia Intercity
Train from Milano Centrale to Firenze S.M.N.
- Ave. Duration
- 3h 42m
- Frequency
- Once daily
- Estimated price
- €30–60
- Website
- Trenitalia Intercity
Train from Roma Termini to Firenze S.M.N.
- Ave. Duration
- 3h 45m
- Frequency
- 6 times a week
- Estimated price
- €28–55
- Website
- Trenitalia Intercity
- Phone
- +33 1 84 94 36 35
- Website
- Oui.SNCF
Train from Lyon Part Dieu to Geneve
- Ave. Duration
- 2h 2m
- Frequency
- Every 3 hours
- Estimated price
- €28–50
- Website
- Oui.SNCF
- Phone
- +33 1 84 94 36 35
- Website
- TGV inOui
Train from Lyon Part Dieu to Geneve
- Ave. Duration
- 1h 50m
- Frequency
- 5 times a week
- Estimated price
- €30–50
- Website
- TGV inOui
- Phone
- +39 800 142 424
- [email protected]
- Website
- at-bus.it
Bus from Firenze Autostazione to Siena-Via Tozzi
- Ave. Duration
- 1h 15m
- Frequency
- Hourly
- Estimated price
- €5–6
- Schedules at
- at-bus.it
Bus from Firenze Autostazione to Siena-Via Tozzi
- Ave. Duration
- 1h 15m
- Frequency
- Hourly
- Estimated price
- €5–6
- Schedules at
- at-bus.it
Rome2Rio's guide to FlixBus
Contact DetailsContact Details
- Phone
- +49 30 300 137 300
- [email protected]
- Website
- Flixbus
Bus from Lyon to Siena
- Ave. Duration
- 11h 20m
- Frequency
- 5 times a week
- Estimated price
- €65–100
- Website
- Flixbus
- Phone
- +39 06 88 93 82 32
- Website
- Itabus S.p.A.
Bus from Lyon Lyon Perrache Bus Station to Florence Villa Constanza Bus Station
- Ave. Duration
- 12h 5m
- Frequency
- Twice daily
- Estimated price
- €40–75
- Website
- Itabus S.p.A.
Want to know more about travelling around Italy
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Booking & Getting There
Lyon to Siena bus services, operated by FlixBus, arrive at Siena station.
Lyon to Siena train services, operated by Trenitalia, arrive at Milano Centrale station.
Yes, the driving distance between Lyon to Siena is 728 km. It takes approximately 8h 1m to drive from Lyon to Siena.
Book your Lyon to Siena train tickets online with Omio.
Book your Lyon to Siena bus tickets online with Omio and FlixBus.
There are 2381+ hotels available in Siena.




































