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How to get fromMacon to Chicagoby train (Amtrak), car, shuttle, plane, or taxi

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There are 6 ways to get from Macon to Chicago by train (Amtrak), car, shuttle, plane, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train (Amtrak)

    best
    1. Take the train from La Plata Station to Chicago Union Stationtrain train Southwest Chief
    6h
    $181–302

  2. Drive 357 mi

    cheapest
    1. Drive from Macon to Chicagocar car 357 mi
    6h 14m
    $66–95

  3. Shuttle to Columbia Regional Airport, fly

    1. Take a shuttle bus from Macon to Columbiashuttle bus
    2. Fly from Columbia Regional Airport (COU) to Chicago O'Hare International Airport (ORD)plane plane COU - ORD
    4h 36m
    $95–325

  4. Shuttle to Kirksville Regional Airport, fly

    1. Take a shuttle bus from Macon to Hy-Vee - Kirksvilleshuttle bus
    2. Fly from Kirksville Regional Airport (IRK) to Chicago O'Hare International Airport (ORD)plane plane IRK - ORD
    4h 7m
    $105–244

  5. Drive to Burlington Municipal Airport, fly

    1. Drive from Macon to Burlington Municipal Airport (BRL)car car
    2. Fly from Burlington Municipal Airport (BRL) to Chicago O'Hare International Airport (ORD)plane plane BRL - ORD
    4h 54m
    $84–175

  6. Shuttle, taxi to Quincy Regional Airport, fly

    1. Take a shuttle bus from Moberly to Hannibalshuttle bus
    2. Take the taxi from Hannibal to Quincy Regional Airport (UIN)taxi taxi
    3. Fly from Quincy Regional Airport (UIN) to Chicago O'Hare International Airport (ORD)plane plane UIN - ORD
    6h 26m
    $132–233

Columbia Regional Airport (COU) to Chicago O'Hare International Airport (ORD) flights

Calendar42Weekly Planes
Duration1h 42mAverage Duration
Ticket$40Cheapest Price
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Questions & Answers

Map of how to get from Macon to Chicago.ExpandLaunch map view
  • Distance: 318.2 mi
  • Duration: 6h

What companies run services between Macon, MO, USA and Chicago, IL, USA?

Amtrak operates a train from La Plata Station to Chicago Union Station once daily. Tickets cost $95–200 and the journey takes 5h 36m.

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