There are 7 ways to get from Madison to Des Moines by plane, bus, car, or bus (Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from Dane County Regional Airport-Truax Field
best- Fly from Dane County Regional Airport-Truax Field (MSN) to Des Moines (DSM)plane MSN - DSM
5h 22m$100–575Drive 274.5 mi
cheapest- Drive from Madison to Des Moinescar 274.5 mi
5h 5m$51–73Bus via Owatonna
- Take the bus from Madison to Rochesterbus
- Take the bus from Rochester to Owatonnabus
- Take the bus from Owatonna to Des Moinesbus
11h 24m$109–189Bus to Chicago O'Hare International Airport, fly
- Take the bus from 250 N. Lake St - Madison UW Campus to O'Hare International Airport - Terminal 1 Departuresbus
- Fly from Chicago O'Hare International Airport (ORD) to Des Moines (DSM)plane ORD - DSM
5h 35m$82–353Bus to General Mitchell International Airport, fly
- Take the bus from Madison, WI-Lake St. to Mitchell Airportbus
- Fly from General Mitchell International Airport (MKE) to Des Moines (DSM)plane MKE - DSM
6h 44m$109–505Bus to Chicago Midway International Airport, fly
- Take the bus from 250 N. Lake St - Madison UW Campus to O'Hare International Airport - Terminal 1 Departuresbus
- Fly from Chicago Midway International Airport (MDW) to Des Moines (DSM)plane MDW - DSM
6h 59m$101–473Bus
- Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus Van Galder
- Take the bus from Chicago Bus Station to Des Moinesbus Greyhound US0123S / ...
11h 37m$76–141
Madison to Des Moines by bus
Comparing Your Travel Options
The cheapest way to get from Madison to Des Moines is to drive which costs $50 - $75 and takes 5h 5m.
The fastest way to get from Madison to Des Moines is to drive which takes 5h 5m and costs $50 - $75.
No, there is no direct bus from Madison to Des Moines. However, there are services departing from Madison and arriving at Des Moines via Rochester and Owatonna. The journey, including transfers, takes approximately 11h 24m.
The distance between Madison and Des Moines is 261 miles. The road distance is 276.1 miles.
The best way to get from Madison to Des Moines without a car is to bus via Owatonna which takes 11h 24m and costs $100 - $190.
It takes approximately 5h 22m to get from Madison to Des Moines, including transfers.
Madison to Des Moines bus services, operated by Jefferson Lines, depart from Madison station.
The best way to get from Madison to Des Moines is to fly which takes 5h 22m and costs $100 - $600. Alternatively, you can bus via Owatonna, which costs $100 - $190 and takes 11h 24m.
Madison to Des Moines bus services, operated by Jefferson Lines, arrive at Rochester station.
Yes, the driving distance between Madison to Des Moines is 276 miles. It takes approximately 5h 5m to drive from Madison to Des Moines.
What companies run services between Madison, WI, USA and Des Moines, IA, USA?
United Airlines, Delta, and American Airlines fly from Dane County Regional Airport-Truax Field (MSN) to Des Moines (DSM) hourly. Alternatively, you can take a bus from Madison to Des Moines via Rochester and Owatonna in around 11h 24m.
- Website
- united.com
Flights from Dane County Regional Airport-Truax Field to Des Moines via Chicago O'Hare International Airport
- Ave. Duration
- 4h 26m
- When
- Every day
- Estimated price
- $80–550
Flights from Dane County Regional Airport-Truax Field to Des Moines via Denver
- Ave. Duration
- 6h 27m
- When
- Every day
- Estimated price
- $170–800
Flights from Chicago O'Hare International Airport to Des Moines
- Ave. Duration
- 1h 30m
- When
- Every day
- Estimated price
- $40–280
Flights from General Mitchell International Airport to Des Moines via Chicago O'Hare International Airport
- Ave. Duration
- 4h 39m
- When
- Every day
- Estimated price
- $70–450
Flights from General Mitchell International Airport to Des Moines via Denver
- Ave. Duration
- 6h 4m
- When
- Every day
- Estimated price
- $160–750
- Phone
- +1-858-800-8898
- Website
- jeffersonlines.com
Bus from Madison to Rochester
- Ave. Duration
- 4h 20m
- Frequency
- Once daily
- Estimated price
- $50–75
- Book at
- Jefferson Lines
- Adult
- $50–75
Bus from Owatonna to Des Moines
- Ave. Duration
- 4h 10m
- Frequency
- 3 times a day
- Estimated price
- $50–75
- Book at
- Jefferson Lines
- Adult
- $50–75
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Booking & Getting There
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