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How to get fromMadison to Kirksvilleby bus, plane, train, car, or shuttle

Find Transport to Kirksville

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There are 9 ways to get from Madison to Kirksville by bus, plane, train, car, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Chicago O'Hare International Airport, fly to Kirksville Regional Airport

    best
    1. Take the bus from 250 N. Lake St - Madison UW Campus to O'Hare International Airport - Terminal 1 Departuresbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Kirksville Regional Airport (IRK)plane plane ORD - IRK
    5h 42m
    $143–439

  2. Drive  315.3 mi

    cheapest
    1. Drive from Madison to Kirksvillecar car 315.3 mi
    6h 33m
    $58–84

  3. Bus, train

    1. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus Van Galder
    2. Take the train from Chicago Union Station to La Plata Stationtrain train Southwest Chief
    10h 9m
    $221–366

  4. Bus, train via Galesburg

    1. Take the bus from 250 N. Lake St - Madison UW Campus to O'Hare International Airport - Terminal 2 Departuresbus bus
    2. Take the bus from Multi-Modal Facility to Watterson Commonsbus bus
    3. Take the bus from Bloomington-Normal to Galesburgbus bus
    4. Take the train from Galesburg Amtrak Station to La Plata Stationtrain train
    13h 15m
    $190–310

  5. Fly Dane County Regional Airport-Truax Field to Kirksville Regional Airport

    1. Fly from Dane County Regional Airport-Truax Field (MSN) to Kirksville Regional Airport (IRK)plane plane MSN - IRK
    5h 28m
    $156–581

  6. Bus to Chicago O'Hare International Airport, fly to Columbia Regional Airport, shuttle

    1. Take the bus from 250 N. Lake St - Madison UW Campus to O'Hare International Airport - Terminal 1 Departuresbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Columbia Regional Airport (COU)plane plane ORD - COU
    3. Take a shuttle bus from Columbia to Hy-Vee - Kirksvilleshuttle bus
    8h 14m
    $118–401

  7. Bus to Chicago O'Hare International Airport, fly to Burlington Municipal Airport, drive

    1. Take the bus from 250 N. Lake St - Madison UW Campus to O'Hare International Airport - Terminal 1 Departuresbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Burlington Municipal Airport (BRL)plane plane ORD - BRL
    3. Drive from Burlington Municipal Airport (BRL) to Kirksvillecar car
    8h 14m
    $135–215

  8. Bus, train via Milwaukee

    1. Take the bus from Madison, WI-Lake St. to Milwaukee, WI - Amtrakbus bus
    2. Take the train from Milwaukee to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to La Plata Stationtrain train
    10h 13m
    $260–425

  9. Bus, train via Chicago

    1. Take the bus from Madison to Chicago Bus Stationbus bus FlixBus 2548 / ...
    2. Take the train from Chicago Union Station to La Plata Stationtrain train Southwest Chief
    10h 28m
    $221–354

Chicago O'Hare International Airport (ORD) to Kirksville Regional Airport (IRK) flights

Calendar7Weekly Planes
Duration1h 30mAverage Duration
Ticket$98Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Madison to Kirksville.ExpandLaunch map view
  • Distance: 420.9 mi
  • Duration: 5h 42m

What companies run services between Madison, WI, USA and Kirksville, MO, USA?

United Airlines, Corporate Flight Management Inc, and American Airlines fly from Dane County Regional Airport-Truax Field (MSN) to Kirksville Regional Airport (IRK) twice daily.

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