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How to get fromMadison to Knoxvilleby plane, bus (Flixbus), bus, train, car, or bus (Greyhound)

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There are 8 ways to get from Madison to Knoxville by plane, bus (Flixbus), bus, train, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Dane County Regional Airport-Truax Field

    best
    1. Fly from Dane County Regional Airport-Truax Field (MSN) to Mcghee Tyson Airport (TYS)plane plane MSN - TYS
    5h 45m
    $217–972

  2. Drive 672.2 mi

    cheapest
    1. Drive from Madison to Knoxvillecar car 672.2 mi
    11h 39m
    $123–178

  3. Bus

    1. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    2. Take the bus from Chicago Bus Station to New York Midtownbus bus
    3. Take the bus from New York to Knoxvillebus bus Nyc
    35h 48m
    $339–539

  4. Bus, train

    1. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    2. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York to Knoxvillebus bus Nyc
    38h 45m
    $519–959

  5. Bus to General Mitchell International Airport, fly

    1. Take the bus from Madison, WI-Lake St. to Mitchell Airportbus bus
    2. Fly from General Mitchell International Airport (MKE) to Mcghee Tyson Airport (TYS)plane plane MKE - TYS
    6h 37m
    $228–1,042

  6. Bus to Chicago O'Hare International Airport, fly

    1. Take the bus from 250 N. Lake St - Madison UW Campus to O'Hare International Airport - Terminal 1 Departuresbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Mcghee Tyson Airport (TYS)plane plane ORD - TYS
    6h 3m
    $179–720

  7. Bus, train via Milwaukee

    1. Take the bus from Madison, WI-Lake St. to Milwaukee, WI - Amtrakbus bus
    2. Take the train from Milwaukee to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Croton-Harmon Amtrak Stationtrain train
    4. Take the train from Croton-Harmon to 125th Street - Harlemtrain train
    5. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    39h 26m
    $488–858

  8. Bus via Baltimore

    1. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    2. Take the bus from Chicago Bus Station to Baltimore Downtown Bus Stationbus bus
    3. Take the bus from Baltimore Downtown Bus Station to Port Authority Bus Terminalbus bus
    4. Take the bus from New York to Knoxvillebus bus Nyc
    40h 24m
    $364–659

Dane County Regional Airport-Truax Field (MSN) to Mcghee Tyson Airport (TYS) flights

Calendar109Weekly Planes
Duration5h 35mAverage Duration
Ticket$163Cheapest Price
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Questions & Answers

Map of how to get from Madison to Knoxville.ExpandLaunch map view
  • Distance: 601.2 mi
  • Duration: 5h 45m

What companies run services between Madison, WI, USA and Knoxville, TN, USA?

United Airlines, Delta, and American Airlines fly from Dane County Regional Airport-Truax Field (MSN) to Mcghee Tyson Airport (TYS) hourly. Alternatively, you can take a bus from 250 N. Lake St - Madison UW Campus to Knoxville via W Jackson Blvd, after S Clinton St, Chicago Bus Station, New York Midtown, 23 St, East Broadway, New York, and Knoxville in around 35h 48m.

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