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How to get fromMadison to Louisvilleby plane, bus (Greyhound, Flixbus), bus, train, car, or bus (Amtrak)

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There are 10 ways to get from Madison to Louisville by plane, bus (Greyhound, Flixbus), bus, train, car, or bus (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Dane County Regional Airport-Truax Field to Louisville International Airport

    best
    1. Fly from Dane County Regional Airport-Truax Field (MSN) to Louisville International Airport (SDF)plane plane MSN - SDF
    6h 42m
    $133–905

  2. Bus

    cheapest
    1. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus Van Galder
    2. Take the bus from Chicago Bus Station to Louisville Bus Stationbus bus Greyhound US0100
    11h 12m
    $66–131

  3. Bus, train via Milwaukee

    1. Take the bus from Madison, WI-Lake St. to Milwaukee, WI - Amtrakbus bus
    2. Take the train from Milwaukee to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Indianapolistrain train
    4. Take the bus from Indianapolis Union Station to Louisville Bus Stationbus bus
    12h 48m
    $107–255

  4. Drive  440.1 mi

    1. Drive from Madison to Louisvillecar car 440.1 mi
    7h 33m
    $81–116

  5. Bus to General Mitchell International Airport, fly to Louisville International Airport

    1. Take the bus from Madison, WI-Lake St. to Mitchell Airportbus bus
    2. Fly from General Mitchell International Airport (MKE) to Louisville International Airport (SDF)plane plane MKE - SDF
    7h 16m
    $142–835

  6. Bus to Chicago O'Hare International Airport, fly to Louisville International Airport

    1. Take the bus from 250 N. Lake St - Madison UW Campus to O'Hare International Airport - Terminal 1 Departuresbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Louisville International Airport (SDF)plane plane ORD - SDF
    6h 36m
    $95–533

  7. Bus to Chicago O'Hare International Airport, fly to Blue Grass Airport, drive

    1. Take the bus from 250 N. Lake St - Madison UW Campus to O'Hare International Airport - Terminal 1 Departuresbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Blue Grass Airport (LEX)plane plane ORD - LEX
    3. Drive from Lexington-Airport-LEX to Louisvillecar car
    6h 44m
    $77–359

  8. Bus to Chicago Midway International Airport, fly to Louisville International Airport

    1. Take the bus from 250 N. Lake St - Madison UW Campus to O'Hare International Airport - Terminal 1 Departuresbus bus
    2. Fly from Chicago Midway International Airport (MDW) to Louisville International Airport (SDF)plane plane MDW - SDF
    7h 49m
    $124–763

  9. Bus via Lafayette

    1. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    2. Take the bus from Chicago Union Station to Lafayette Amtrak Stationbus bus
    3. Take the bus from Lafayette Amtrak Station to Louisville, KYbus bus
    12h 35m
    $79–151

  10. Bus, train

    1. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    2. Take the train from Chicago Union Station to Indianapolistrain train
    3. Take the bus from Indianapolis Union Station to Louisville Bus Stationbus bus
    12h 44m
    $93–221

Madison to Louisville by bus and foot

Calendar40Weekly Services
Duration11h 12mAverage Duration
Ticket$66Cheapest Price
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Comparing Your Travel Options

Map of how to get from Madison to Louisville.ExpandLaunch map view
  • Distance: 404 mi
  • Duration: 6h 42m

What companies run services between Madison, WI, USA and Louisville, KY, USA?

United Airlines, Delta, and American Airlines fly from Dane County Regional Airport-Truax Field (MSN) to Louisville International Airport (SDF) hourly. Alternatively, you can take a bus from 250 N. Lake St - Madison UW Campus to Louisville Bus Station via W Jackson Blvd, after S Clinton St and Chicago Bus Station in around 11h 12m.

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