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How to get fromMadison to Louisvilleby plane, bus (Flixbus, Greyhound, Amtrak), bus, train, car, or bus (Amtrak)

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There are 10 ways to get from Madison to Louisville by plane, bus (Flixbus, Greyhound, Amtrak), bus, train, car, or bus (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Dane County Regional Airport-Truax Field to Louisville International Airport

    best
    1. Fly from Dane County Regional Airport-Truax Field (MSN) to Louisville International Airport (SDF)plane plane MSN - SDF
    6h 19m
    $98–655

  2. Bus

    cheapest
    1. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus Van Galder
    2. Take the bus from Chicago Union Station to Louisville, KYbus bus Chicago
    11h 45m
    $76–116

  3. Bus via Indianapolis

    1. Take the bus from Madison to Chicago Bus Stationbus bus
    2. Take the bus from Chicago Bus Station to Indianapolis Union Stationbus bus
    3. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    11h 10m
    $80–141

  4. Bus, train via Milwaukee

    1. Take the bus from Madison, WI-Lake St. to Milwaukee, WI - Amtrakbus bus
    2. Take the train from Milwaukee to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Indianapolistrain train
    4. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    12h 53m
    $187–330

  5. Drive  440.1 mi

    1. Drive from Madison to Louisvillecar car 440.1 mi
    7h 33m
    $81–116

  6. Bus to General Mitchell International Airport, fly to Louisville International Airport

    1. Take the bus from Madison, WI-Lake St. to Mitchell Airportbus bus
    2. Fly from General Mitchell International Airport (MKE) to Louisville International Airport (SDF)plane plane MKE - SDF
    7h 6m
    $142–835

  7. Bus to Chicago O'Hare International Airport, fly to Louisville International Airport

    1. Take the bus from 250 N. Lake St - Madison UW Campus to O'Hare International Airport - Terminal 1 Departuresbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Louisville International Airport (SDF)plane plane ORD - SDF
    6h 41m
    $95–533

  8. Bus to Chicago O'Hare International Airport, fly to Blue Grass Airport, drive

    1. Take the bus from 250 N. Lake St - Madison UW Campus to O'Hare International Airport - Terminal 1 Departuresbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Blue Grass Airport (LEX)plane plane ORD - LEX
    3. Drive from Lexington-Airport-LEX to Louisvillecar car
    6h 43m
    $77–339

  9. Bus to Chicago Midway International Airport, fly to Louisville International Airport

    1. Take the bus from 250 N. Lake St - Madison UW Campus to O'Hare International Airport - Terminal 1 Departuresbus bus
    2. Fly from Chicago Midway International Airport (MDW) to Louisville International Airport (SDF)plane plane MDW - SDF
    7h 54m
    $129–813

  10. Bus, train

    1. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    2. Take the train from Chicago Union Station to Indianapolistrain train
    3. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    12h 49m
    $148–271

Madison to Louisville by bus

Calendar14Weekly Buses
Duration11h 10mAverage Duration
Ticket$80Cheapest Price
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Comparing Your Travel Options

Map of how to get from Madison to Louisville.ExpandLaunch map view
  • Distance: 404 mi
  • Duration: 6h 19m

What companies run services between Madison, WI, USA and Louisville, KY, USA?

American Airlines, United Airlines, and Delta fly from Dane County Regional Airport-Truax Field (MSN) to Louisville International Airport (SDF) hourly. Alternatively, you can take a bus from Madison to Louisville, KY via Chicago Bus Station and Indianapolis Union Station in around 11h 10m.

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