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How to get fromMadison to Mayo Clinicby bus, car, or plane

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There are 4 ways to get from Madison to Mayo Clinic by bus, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Madison to Rochesterbus bus Jefferson 966 / ...
    4h 28m
    $50–75
  2. Drive 205.4 mi

    cheapest
    1. Drive from Madison to Mayo Cliniccar car 205.4 mi
    3h 42m
    $38–55
  3. Fly to Rochester

    1. Fly from Dane County Regional Airport-Truax Field (MSN) to Rochester (RST)plane plane MSN - RST
    6h 25m
    $68–442
  4. Fly to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Dane County Regional Airport-Truax Field (MSN) to Minneapolis–Saint Paul International Airport (MSP)plane plane MSN - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    5h 31m
    $124–524

Dane County Regional Airport-Truax Field (MSN) to Rochester (RST) flights

Calendar44Weekly Planes
Duration4h 29mAverage Duration
Ticket$65Cheapest Price
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Questions & Answers

What companies run services between Madison, WI, USA and Mayo Clinic, MN, USA?

Jefferson Lines operates a bus from Madison to Rochester twice daily. Tickets cost $50–75 and the journey takes 4h 20m. Alternatively, American Airlines, United Airlines, and Delta fly from Dane County Regional Airport-Truax Field (MSN) to Rochester (RST) every 4 hours.

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