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How to get fromMadison to Saint Charlesby plane, bus, train, bus (Flixbus, Greyhound), or car

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There are 8 ways to get from Madison to Saint Charles by plane, bus, train, bus (Flixbus, Greyhound), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Dane County Regional Airport-Truax Field

    best
    1. Fly from Dane County Regional Airport-Truax Field (MSN) to Lambert–St. Louis International Airport (STL)plane plane MSN - STL
    6h 12m
    $106–656

  2. Drive 372.6 mi

    cheapest
    1. Drive from Madison to Saint Charlescar car 372.6 mi
    6h 11m
    $68–99

  3. Bus, train

    1. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus Van Galder
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    11h 11m
    $120–250

  4. Bus

    1. Take the bus from Madison to Chicago Bus Stationbus bus FlixBus 2548 / ...
    2. Take the bus from Chicago Bus Station to St Louis Bus Stationbus bus FlixBus 2510 / ...
    13h 3m
    $74–132

  5. Bus to General Mitchell International Airport, fly

    1. Take the bus from Madison, WI-Lake St. to Mitchell Airportbus bus
    2. Fly from General Mitchell International Airport (MKE) to Lambert–St. Louis International Airport (STL)plane plane MKE - STL
    5h 22m
    $497–876

  6. Bus to Chicago O'Hare International Airport, fly

    1. Take the bus from 250 N. Lake St - Madison UW Campus to O'Hare International Airport - Terminal 1 Departuresbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Lambert–St. Louis International Airport (STL)plane plane ORD - STL
    6h 21m
    $298–754

  7. Bus to Chicago Midway International Airport, fly

    1. Take the bus from 250 N. Lake St - Madison UW Campus to O'Hare International Airport - Terminal 1 Departuresbus bus
    2. Fly from Chicago Midway International Airport (MDW) to Lambert–St. Louis International Airport (STL)plane plane MDW - STL
    7h 43m
    $112–614

  8. Bus, train via Milwaukee

    1. Take the bus from Madison, WI-Lake St. to Milwaukee, WI - Amtrakbus bus
    2. Take the train from Milwaukee to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    11h 15m
    $134–272

Madison to Saint Charles by bus and train

Calendar38Weekly Services
Duration11h 11mAverage Duration
Ticket$120Cheapest Price
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Questions & Answers

Map of how to get from Madison to Saint Charles.ExpandLaunch map view
  • Distance: 329.5 mi
  • Duration: 6h 12m

What companies run services between Madison, WI, USA and Saint Charles, MO, USA?

United Airlines, Delta, and American Airlines fly from Dane County Regional Airport-Truax Field (MSN) to Lambert–St. Louis International Airport (STL) hourly. Alternatively, you can take a bus from Madison to 4375 Rider Trail North Sb via Chicago Bus Station, St Louis Bus Station, Civic Center Transit Center, and North Hanley Transit Center in around 13h 3m.

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