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How to get fromMadison to Saint Charlesby plane, bus, train, bus (Flixbus, Greyhound), or car

Find Transport to Saint Charles

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There are 8 ways to get from Madison to Saint Charles by plane, bus, train, bus (Flixbus, Greyhound), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Dane County Regional Airport-Truax Field

    best
    1. Fly from Dane County Regional Airport-Truax Field (MSN) to Lambert–St. Louis International Airport (STL)plane plane MSN - STL
    6h 24m
    $122–726

  2. Drive  372.5 mi

    cheapest
    1. Drive from Madison to Saint Charlescar car 372.5 mi
    6h 11m
    $68–99

  3. Bus, train

    1. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus Van Galder
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    11h 20m
    $111–250

  4. Bus

    1. Take the bus from Madison to Chicago Bus Stationbus bus FlixBus 2548 / ...
    2. Take the bus from Chicago Bus Station to St Louis Bus Stationbus bus FlixBus 2510 / ...
    13h 12m
    $89–135

  5. Bus to General Mitchell International Airport, fly

    1. Take the bus from Madison, WI-Lake St. to Mitchell Airportbus bus
    2. Fly from General Mitchell International Airport (MKE) to Lambert–St. Louis International Airport (STL)plane plane MKE - STL
    5h 32m
    $521–906

  6. Bus to Chicago O'Hare International Airport, fly

    1. Take the bus from 250 N. Lake St - Madison UW Campus to O'Hare International Airport - Terminal 1 Departuresbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Lambert–St. Louis International Airport (STL)plane plane ORD - STL
    6h 37m
    $364–774

  7. Bus to Chicago Midway International Airport, fly

    1. Take the bus from 250 N. Lake St - Madison UW Campus to O'Hare International Airport - Terminal 1 Departuresbus bus
    2. Fly from Chicago Midway International Airport (MDW) to Lambert–St. Louis International Airport (STL)plane plane MDW - STL
    7h 54m
    $123–634

  8. Bus, train via Milwaukee

    1. Take the bus from Madison, WI-Lake St. to Milwaukee, WI - Amtrakbus bus
    2. Take the train from Milwaukee to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    11h 24m
    $125–284

Dane County Regional Airport-Truax Field (MSN) to Lambert–St. Louis International Airport (STL) flights

Calendar174Weekly Planes
Duration5h 30mAverage Duration
Ticket$107Cheapest Price
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Comparing Your Travel Options

Map of how to get from Madison to Saint Charles.ExpandLaunch map view
  • Distance: 335.2 mi
  • Duration: 6h 24m

What companies run services between Madison, WI, USA and Saint Charles, MO, USA?

United Airlines, Delta, and American Airlines fly from Dane County Regional Airport-Truax Field (MSN) to Lambert–St. Louis International Airport (STL) hourly. Alternatively, you can take a bus from Madison to Saint Charles via Chicago Bus Station, St Louis Bus Station, Civic Center Transit Center, North Hanley Transit Center, and 4375 Rider Trail North Sb in around 13h 12m.

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