There are 4 ways to get from Madrid to Mayo Clinic by plane, car, or bus
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Rochester
best- Fly from Adolfo Suárez Madrid–Barajas Airport (MAD) to Rochester (RST)plane MAD - RST
19h 27m$242–941Fly to Waterloo Municipal Airport, drive
- Fly from Adolfo Suárez Madrid–Barajas Airport (MAD) to Waterloo Municipal Airport (ALO)plane MAD - ALO
- Drive from Waterloo Municipal Airport (ALO) to Mayo Cliniccar
21h 39m$260–930Fly to Minneapolis–Saint Paul International Airport, bus
- Fly from Adolfo Suárez Madrid–Barajas Airport (MAD) to Minneapolis–Saint Paul International Airport (MSP)plane MAD - MSP
- Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus
17h 36m$361–1,251Fly to Dane County Regional Airport-Truax Field, bus
- Fly from Adolfo Suárez Madrid–Barajas Airport (MAD) to Dane County Regional Airport-Truax Field (MSN)plane MAD - MSN
- Take the bus from Madison to Rochesterbus
21h 24m$283–978
Adolfo Suárez Madrid–Barajas Airport (MAD) to Rochester (RST) flights
Comparing Your Travel Options
The cheapest way to get from Madrid to Mayo Clinic is to fly which costs $240 - $950 and takes 19h 27m.
The fastest way to get from Madrid to Mayo Clinic is to fly and bus which takes 17h 36m and costs $360 - $1,300.
The distance between Madrid and Mayo Clinic is 4363 miles.
It takes approximately 19h 27m to get from Madrid to Mayo Clinic, including transfers.
There are 76+ hotels available in Mayo Clinic.
What companies run services between Madrid, Spain and Mayo Clinic, MN, USA?
American Airlines, Iberia, and two other airlines fly from Adolfo Suárez Madrid–Barajas Airport (MAD) to Rochester (RST) twice daily.
- Website
- aa.com
Flights from Adolfo Suárez Madrid–Barajas Airport to Rochester via Chicago O'Hare
- Ave. Duration
- 18h 19m
- When
- Every day
- Estimated price
- $240–900
Flights from Adolfo Suárez Madrid–Barajas Airport to Waterloo Municipal Airport via Chicago O'Hare
- Ave. Duration
- 18h 18m
- When
- Every day
- Estimated price
- $240–1,100
Flights from Adolfo Suárez Madrid–Barajas Airport to Waterloo Municipal Airport via Philadelphia, Chicago O'Hare
- Ave. Duration
- 17h 23m
- When
- Every day
- Estimated price
- $250–900
Flights from Adolfo Suárez Madrid–Barajas Airport to Waterloo Municipal Airport via Toronto, Chicago O'Hare
- Ave. Duration
- 17h 53m
- When
- Every day
- Estimated price
- $240–1,100
Flights from Adolfo Suárez Madrid–Barajas Airport to Waterloo Municipal Airport via Barcelona, Chicago O'Hare
- Ave. Duration
- 22h 13m
- When
- Sunday
- Estimated price
- $270–1,000
Flights from Adolfo Suárez Madrid–Barajas Airport to Waterloo Municipal Airport via Montreal, Chicago O'Hare
- Ave. Duration
- 17h 13m
- When
- Tuesday, Wednesday, Thursday, Saturday, and Sunday
- Estimated price
- $240–900
Flights from Adolfo Suárez Madrid–Barajas Airport to Minneapolis–Saint Paul International Airport via Chicago O'Hare
- Ave. Duration
- 12h 11m
- When
- Every day
- Estimated price
- $320–1,200
Flights from Adolfo Suárez Madrid–Barajas Airport to Minneapolis–Saint Paul International Airport via Philadelphia
- Ave. Duration
- 14h 52m
- When
- Every day
- Estimated price
- $330–1,200
Flights from Adolfo Suárez Madrid–Barajas Airport to Dane County Regional Airport-Truax Field via Chicago O'Hare
- Ave. Duration
- 12h 41m
- When
- Every day
- Estimated price
- $230–900
Flights from Adolfo Suárez Madrid–Barajas Airport to Dane County Regional Airport-Truax Field via Boston
- Ave. Duration
- 14h 2m
- When
- Every day
- Estimated price
- $280–1,000
Flights from Adolfo Suárez Madrid–Barajas Airport to Dane County Regional Airport-Truax Field via Dallas/Ft.Worth
- Ave. Duration
- 17h 43m
- When
- Every day
- Estimated price
- $310–1,300
Flights from Adolfo Suárez Madrid–Barajas Airport to Dane County Regional Airport-Truax Field via Charlotte
- Ave. Duration
- 17h
- When
- Every day
- Estimated price
- $260–950
- Website
- delta.com
Flights from Adolfo Suárez Madrid–Barajas Airport to Rochester via London Heathrow, Minneapolis–Saint Paul International Airport
- Ave. Duration
- 15h 50m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $260–950
Flights from Adolfo Suárez Madrid–Barajas Airport to Rochester via Toronto, Minneapolis–Saint Paul International Airport
- Ave. Duration
- 16h 15m
- When
- Monday, Tuesday, and Thursday
- Estimated price
- $250–900
Flights from Adolfo Suárez Madrid–Barajas Airport to Minneapolis–Saint Paul International Airport via Boston
- Ave. Duration
- 13h 32m
- When
- Every day
- Estimated price
- $320–1,200
Flights from Adolfo Suárez Madrid–Barajas Airport to Minneapolis–Saint Paul International Airport via New York JFK
- Ave. Duration
- 17h 51m
- When
- Every day
- Estimated price
- $320–1,200
Flights from Adolfo Suárez Madrid–Barajas Airport to Minneapolis–Saint Paul International Airport via Toronto
- Ave. Duration
- 12h 17m
- When
- Monday, Tuesday, and Thursday
- Estimated price
- $310–1,200
Flights from Adolfo Suárez Madrid–Barajas Airport to Dane County Regional Airport-Truax Field via Atlanta
- Ave. Duration
- 15h 50m
- When
- Monday
- Estimated price
- $270–1,000
- Website
- united.com
Flights from Adolfo Suárez Madrid–Barajas Airport to Minneapolis–Saint Paul International Airport via Toronto
- Ave. Duration
- 14h 50m
- When
- Monday, Tuesday, Thursday, and Saturday
- Estimated price
- $310–1,200
Flights from Adolfo Suárez Madrid–Barajas Airport to Dane County Regional Airport-Truax Field via Newark
- Ave. Duration
- 19h 22m
- When
- Every day
- Estimated price
- $240–900
- Website
- aircanada.com
Flights from Adolfo Suárez Madrid–Barajas Airport to Minneapolis–Saint Paul International Airport via Toronto
- Ave. Duration
- 14h 50m
- When
- Monday, Tuesday, Thursday, and Saturday
- Estimated price
- $310–1,200
Bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochester
- Ave. Duration
- 1h 45m
- Frequency
- Every 4 hours
- Estimated price
- $40–50
- Website
- Groome Transportation - Rochester - MSP
- Phone
- +1-858-800-8898
- Website
- jeffersonlines.com
Bus from Madison to Rochester
- Ave. Duration
- 4h 20m
- Frequency
- Once daily
- Estimated price
- $50–75
- Book at
- Jefferson Lines
- Adult
- $50–75
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