There are 9 ways to get from Madrid to Mendrisio by plane, train, train (Renfe, Ouigo, Trenitalia), bus, car, or train (Renfe, TGV, Trenitalia)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Milano Malpensa Airport, train
best- Fly from Adolfo Suárez Madrid–Barajas Airport (MAD) to Milano Malpensa Airport (MXP)plane MAD - MXP
- Take the train from Malpensa Aeroporto T1 to Mendrisiotrain
5h 48mCHF 26–186Train via Barcelona
- Take the train from Madrid-Puerta de Atocha-Almudena Grandes to Barcelona-Santstrain Ave
- Take the train from Barcelona-Sants to Lyon Part Dieutrain
- Take the train from Lyon Part Dieu to Milano Centraletrain Fr
- Take the train from Milano Centrale to Mendrisiotrain
16h 26mCHF 183–347Bus
- Take the bus from Madrid to Milanbus FlixBus N1138
- Take the bus from Milan to Comobus FlixBus 1524 / ...
26h 17mCHF 136–205Drive 1,495.5 km
- Drive from Madrid to Mendrisiocar 1,495.5 km
16h 39mCHF 249–360Fly to Milan Linate Airport, train
- Fly from Adolfo Suárez Madrid–Barajas Airport (MAD) to Milan Linate Airport (LIN)plane MAD - LIN
- Take the train from Monza to Mendrisiotrain
6h 39mCHF 71–200Fly to Il Caravaggio International Airport, bus, train
- Fly from Adolfo Suárez Madrid–Barajas Airport (MAD) to Il Caravaggio International Airport (BGY)plane MAD - BGY
- Take the bus from Milan Bergamo Orio al Serio Airport to Piazza Luigi di Savoiabus
- Take the train from Milano Centrale to Mendrisiotrain
7h 2mCHF 72–297Fly to Zurich Airport, train
- Fly from Adolfo Suárez Madrid–Barajas Airport (MAD) to Zurich Airport (ZRH)plane MAD - ZRH
- Take the train from Zürich HB to Luganotrain
7h 28mCHF 120–322Train
- Take the train from Madrid-Puerta de Atocha-Almudena Grandes to Marseille St Charlestrain
- Take the train from Marseille St Charles to Nice Villetrain Tgv
- Take the train from Ventimiglia to Milano Centraletrain Ic
- Take the train from Milano Centrale to Mendrisiotrain
19h 3mCHF 227–359Bus, train
- Take the bus from Estación Sur de Autobuses to Lyon - Gerland Bus Stationbus
- Take the bus from Lione to Turin Stura Bus Stationbus
- Take the bus from Torino Auchan to Milan Malpensa Airportbus 020
- Take the train from Malpensa Aeroporto T2 to Mendrisiotrain S50
27h 38mCHF 110–207
Madrid to Mendrisio by train
Comparing Your Travel Options
The cheapest way to get from Madrid to Mendrisio is to fly and train which costs SFr 25 - SFr 190 and takes 5h 48m.
The fastest way to get from Madrid to Mendrisio is to fly and train which takes 5h 48m and costs SFr 25 - SFr 190.
No, there is no direct bus from Madrid to Mendrisio. However, there are services departing from Madrid and arriving at Mendrisio, Autosilo via Milan, Como - San Rocchetto and Chiasso, Stazione. The journey, including transfers, takes approximately 26h 17m.
No, there is no direct train from Madrid to Mendrisio. However, there are services departing from Madrid-Puerta de Atocha-Almudena Grandes and arriving at Mendrisio via Barcelona-Sants, Lyon Part Dieu and Milano Centrale. The journey, including transfers, takes approximately 16h 26m.
The distance between Madrid and Mendrisio is 1218 km. The road distance is 1495.5 km.
The best way to get from Madrid to Mendrisio without a car is to train via Barcelona which takes 16h 26m and costs SFr 180 - SFr 350.
It takes approximately 5h 48m to get from Madrid to Mendrisio, including transfers.
Madrid to Mendrisio bus services, operated by FlixBus, depart from Madrid station.
Madrid to Mendrisio train services, operated by Renfe AVE, depart from Madrid-Puerta de Atocha-Almudena Grandes station.
The best way to get from Madrid to Mendrisio is to train via Barcelona which takes 16h 26m and costs SFr 180 - SFr 350. Alternatively, you can bus, which costs SFr 130 - SFr 210 and takes 26h 17m.
What companies run services between Madrid, Spain and Mendrisio, Switzerland?
You can take a train from Madrid-Puerta de Atocha-Almudena Grandes to Mendrisio via Barcelona-Sants, Lyon Part Dieu, and Milano Centrale in around 16h 26m. Alternatively, you can take a bus from Madrid to Mendrisio, Autosilo via Milan, Como, Como - San Rocchetto, and Chiasso, Stazione in around 26h 17m.
- Website
- ryanair.com
Flights from Adolfo Suárez Madrid–Barajas Airport to Milano Malpensa Airport
- Ave. Duration
- 2h 9m
- When
- Every day
- Estimated price
- CHF 35–150
Flights from Adolfo Suárez Madrid–Barajas Airport to Il Caravaggio International Airport
- Ave. Duration
- 2h 15m
- When
- Every day
- Estimated price
- CHF 45–230
Flights from Adolfo Suárez Madrid–Barajas Airport to Il Caravaggio International Airport via Ibiza
- Ave. Duration
- 4h 27m
- When
- Wednesday and Monday
- Estimated price
- CHF 45–230
Flights from Adolfo Suárez Madrid–Barajas Airport to Il Caravaggio International Airport via Palma Mallorca
- Ave. Duration
- 4h 17m
- When
- Thursday and Friday
- Estimated price
- CHF 45–230
- Website
- iberia.com
Flights from Adolfo Suárez Madrid–Barajas Airport to Milano Malpensa Airport
- Ave. Duration
- 2h 11m
- When
- Every day
- Estimated price
- CHF 35–200
Flights from Adolfo Suárez Madrid–Barajas Airport to Milan Linate Airport
- Ave. Duration
- 2h 10m
- When
- Every day
- Estimated price
- CHF 55–160
Flights from Adolfo Suárez Madrid–Barajas Airport to Zurich Airport
- Ave. Duration
- 2h 21m
- When
- Every day
- Estimated price
- CHF 60–160
Flights from Adolfo Suárez Madrid–Barajas Airport to Zurich Airport via Barcelona
- Ave. Duration
- 5h 15m
- When
- Monday, Tuesday, Thursday, Friday, and Sunday
- Estimated price
- CHF 70–210
- Website
- vueling.com
Flights from Adolfo Suárez Madrid–Barajas Airport to Milano Malpensa Airport
- Ave. Duration
- 2h 11m
- When
- Every day
- Estimated price
- CHF 35–200
Flights from Adolfo Suárez Madrid–Barajas Airport to Milano Malpensa Airport via Bilbao
- Ave. Duration
- 4h 25m
- When
- Saturday
- Estimated price
- CHF 90–170
Flights from Adolfo Suárez Madrid–Barajas Airport to Milan Linate Airport
- Ave. Duration
- 2h 10m
- When
- Every day
- Estimated price
- CHF 55–160
Flights from Adolfo Suárez Madrid–Barajas Airport to Zurich Airport
- Ave. Duration
- 2h 21m
- When
- Every day
- Estimated price
- CHF 60–160
Flights from Adolfo Suárez Madrid–Barajas Airport to Zurich Airport via Barcelona
- Ave. Duration
- 5h 15m
- When
- Monday, Tuesday, Thursday, Friday, and Sunday
- Estimated price
- CHF 70–210
- Website
- aireuropa.com
Flights from Adolfo Suárez Madrid–Barajas Airport to Milano Malpensa Airport
- Ave. Duration
- 2h 5m
- When
- Every day
- Estimated price
- CHF 45–180
Flights from Adolfo Suárez Madrid–Barajas Airport to Zurich Airport
- Ave. Duration
- 2h 15m
- When
- Every day
- Estimated price
- CHF 60–190
- Website
- flyulendo.com
Flights from Adolfo Suárez Madrid–Barajas Airport to Milano Malpensa Airport
- Ave. Duration
- 2h 15m
- When
- Every day
- Estimated price
- CHF 19–140
- Website
- swiss.com
Flights from Adolfo Suárez Madrid–Barajas Airport to Zurich Airport
- Ave. Duration
- 2h 17m
- When
- Every day
- Estimated price
- CHF 65–220
- Phone
- +39 02 7249 4494
- [email protected]
- Website
- Trenord
Train from Malpensa Aeroporto T1 to Mendrisio
- Ave. Duration
- 1h 8m
- Frequency
- Hourly
- Estimated price
- CHF 4–6
- Website
- Trenord
Train from Monza to Mendrisio
- Ave. Duration
- 48 min
- Frequency
- Hourly
- Estimated price
- CHF 2–4
- Website
- Trenord
Train from Malpensa Aeroporto T2 to Mendrisio
- Ave. Duration
- 1h 14m
- Frequency
- Hourly
- Estimated price
- CHF 4–6
- Website
- Trenord
Train from Malpensa Aeroporto T1 to Mendrisio
- Ave. Duration
- 1h 8m
- Frequency
- Hourly
- Estimated price
- CHF 17–25
- Website
- Swiss Federal Railways (SBB CFF FFS)
Train from Milano Centrale to Mendrisio
- Ave. Duration
- 58 min
- Frequency
- Hourly
- Estimated price
- CHF 17–25
- Website
- Swiss Federal Railways (SBB CFF FFS)
Train from Milano Centrale to Mendrisio
- Ave. Duration
- 58 min
- Frequency
- Hourly
- Estimated price
- CHF 17–25
- Website
- Swiss Federal Railways (SBB CFF FFS)
Train from Zürich HB to Lugano
- Ave. Duration
- 1h 55m
- Frequency
- Hourly
- Estimated price
- CHF 50–75
- Website
- Swiss Federal Railways (SBB CFF FFS)
Train from Milano Centrale to Mendrisio
- Ave. Duration
- 58 min
- Frequency
- Hourly
- Estimated price
- CHF 17–25
- Website
- Swiss Federal Railways (SBB CFF FFS)
Train from Malpensa Aeroporto T2 to Mendrisio
- Ave. Duration
- 1h 14m
- Frequency
- Hourly
- Estimated price
- CHF 18–26
- Website
- Swiss Federal Railways (SBB CFF FFS)
Rome2Rio's guide to Renfe AVE
Contact DetailsContact Details
- Phone
- +34 91 232 03 20
- Website
- Renfe AVE
Train from Madrid-Puerta de Atocha-Almudena Grandes to Barcelona-Sants
- Ave. Duration
- 3h 2m
- Frequency
- Every 30 minutes
- Estimated price
- CHF 80–150
- Website
- Renfe AVE
- Phone
- +34 900 926 851
- [email protected]
- Website
- Iryo
Train from Madrid-Puerta de Atocha-Almudena Grandes to Barcelona-Sants
- Ave. Duration
- 3h 24m
- Frequency
- Hourly
- Estimated price
- CHF 55–90
- Website
- Iryo
- Phone
- +34 900 759 781
- Website
- Ouigo
Train from Madrid-Puerta de Atocha-Almudena Grandes to Barcelona-Sants
- Ave. Duration
- 3h 27m
- Frequency
- Hourly
- Estimated price
- CHF 45–75
- Website
- Ouigo
Rome2Rio's guide to Renfe Viajeros
Contact DetailsContact Details
- Phone
- +34 91 232 03 20
- Website
- Renfe Viajeros
Train from Madrid-Puerta de Atocha-Almudena Grandes to Barcelona-Sants
- Ave. Duration
- 3h 29m
- Frequency
- 4 times a day
- Estimated price
- CHF 70–110
- Website
- Renfe Viajeros
Train from Barcelona-Sants to Lyon Part Dieu
- Ave. Duration
- 5h 6m
- Frequency
- Twice daily
- Estimated price
- CHF 75–110
- Website
- Renfe Viajeros
Train from Madrid-Puerta de Atocha-Almudena Grandes to Marseille St Charles
- Ave. Duration
- 8h 42m
- Frequency
- Twice daily
- Estimated price
- CHF 130–200
- Website
- Renfe Viajeros
- Phone
- +39.06.5210550
- Website
- Trenitalia
Train from Lyon Part Dieu to Milano Centrale
- Ave. Duration
- 4h 44m
- Frequency
- 4 times a day
- Estimated price
- CHF 45–70
- Website
- Trenitalia
Train from Ventimiglia to Milano Centrale
- Ave. Duration
- 4h 30m
- Frequency
- Twice daily
- Estimated price
- CHF 30–45
- Website
- Trenitalia
- Phone
- +33 1 84 94 36 35
- Website
- TGV inOui
Train from Marseille St Charles to Nice Ville
- Ave. Duration
- 2h 36m
- Frequency
- Every 3 hours
- Estimated price
- CHF 40–65
- Website
- TGV inOui
- Phone
- +33 4 13 94 30 50
- Website
- Zou! Lignes Express Régionales
Train from Marseille St Charles to Nice Ville
- Ave. Duration
- 2h 41m
- Frequency
- Hourly
- Estimated price
- CHF 50–75
- Website
- Zou! Lignes Express Régionales
- Phone
- +39 06 68475475
- Website
- Trenitalia Intercity
Train from Ventimiglia to Milano Centrale
- Ave. Duration
- 3h 50m
- Frequency
- Every 2 hours
- Estimated price
- CHF 27–55
- Website
- Trenitalia Intercity
- Phone
- +49 30 300 137 300
- [email protected]
- Website
- Flixbus
Bus from Madrid to Milan
- Ave. Duration
- 23h 5m
- Frequency
- Once daily
- Estimated price
- CHF 130–200
- Website
- Flixbus
Bus from Milan to Como
- Ave. Duration
- 1h 5m
- Frequency
- Every 4 hours
- Estimated price
- CHF 3–6
- Website
- Flixbus
- [email protected]
- Website
- TERRAVISION
Bus from Milan Bergamo Orio al Serio Airport to Piazza Luigi di Savoia
- Ave. Duration
- 50 min
- Frequency
- Every 30 minutes
- Estimated price
- CHF 4–21
- Website
- TERRAVISION
- Phone
- 035.319366
- [email protected]
- Website
- orioshuttle.com
Bus from Milan Bergamo Orio al Serio Airport to Piazza Luigi di Savoia
- Ave. Duration
- 50 min
- Frequency
- Every 30 minutes
- Estimated price
- CHF 10–13
- Schedules at
- orioshuttle.com
- Phone
- +3 318 576 2228
- Website
- BlaBlaCar Bus
Bus from Estación Sur de Autobuses to Lyon - Gerland Bus Station
- Ave. Duration
- 17h 10m
- Frequency
- Every 4 hours
- Estimated price
- CHF 80–140
- Website
- BlaBlaCar Bus
- Phone
- +39 06 88 93 82 32
- Website
- Itabus S.p.A.
Bus from Lione to Turin Stura Bus Station
- Ave. Duration
- 5h 15m
- Frequency
- Once daily
- Estimated price
- CHF 15–27
- Website
- Itabus S.p.A.
- Phone
- 035 289000
- Website
- Arriva Italia - Torino
Bus from Torino Auchan to Milan Malpensa Airport
- Ave. Duration
- 1h 44m
- Frequency
- Hourly
- Estimated price
- CHF 9–21
- Website
- Arriva Italia - Torino
Want to know more about travelling around Switzerland
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Booking & Getting There
Madrid to Mendrisio bus services, operated by FlixBus, arrive at Milan station.
Madrid to Mendrisio train services, operated by Renfe AVE, arrive at Barcelona-Sants station.
Yes, the driving distance between Madrid to Mendrisio is 1496 km. It takes approximately 16h 39m to drive from Madrid to Mendrisio.
There are 5477+ hotels available in Mendrisio.

























































